OTSU Kinya ≪Cardiovascular Medicine≫ “The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.”
2007-4-22
Publish Nature Medicine, 13: 619-624 (2007)
Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism in starving cells. Here, we report that constitutive autophagy in the heart under baseline conditions is a homeostatic mechanism for maintaining cardiomyocyte size and global cardiac structure and function, and that upregulation of autophagy in failing hearts is an adaptive response for protecting cells from hemodynamic stress.
