Specially Appointed Associate Professor
Naoki Hirose
Publications
- Hirose N., Mizuno S., Niwa Y., Hara T., Yamamoto H., Koyama E., Ueda J., Tsuboi T., Takata A. “Genome-wide identification and characterization of QTLs for transcriptional noise in human midbrain cells” bioRxiv 2025. doi: 10.1101/2025.02.01.635574
- Watabe T., Kaneda-Nakashima K., Kadonaga Y., Ooe K., Sampunta T., Hirose N., Yin X., Haba H., Kon Y., Toyoshima A., Cardinale J., Giesel F.L., Fukase K., Tomiyama N., Shirakami Y. “Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer.” Int.J. Mol. Sci. 25:5667, 2024. doi: 10.3390/ijms25115667
- Hiura K., Watanabe M., Hirose N., Nakano K., Okamura T., Sasaki H., Sasaki N. “The mitotic spindle positioning (MISP) facilitates colorectal cancer progression by forming a complex with Opa interacting protein 5 (OIP5) and activating the JAK2-STAT3 signaling pathway.” Int.J. Mol. Sci. 25:3061, 2024. doi: 10.3390/ijms25053061
- Jayakumar V., Nishimura O., Kadota M., Hirose N., Sano H., Murakawa Y., Yamamoto Y., Nakaya M., Tsukiyama T., Seita Y., Nakamura S., Kawai J., Sasaki E., Ema M., Kuraku S., Kawaji H., Sakakibara Y. “Chromosomal-scale de novo genome assemblies of cynomolgus macaque and common marmoset.” Sci. Data 8:159, 2021. doi: 10.1038/s41597-021-00935-6
- Hosaka T., Yamashita T., Teramoto S., Hirose N., Tamaoka A., Kwak S. “ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs.” Neurosci. Res. 147:48-57, 2019. doi : 10.1016/j.neures.2018.11.005
- Hirose N. “Investigation into the ADARB1 Regulatory Mechanism in the Human Spinal Motor Neurons : An Implication for the Amyotrophic Lateral Sclerosis Pathogenesis” Doctoral dissertation (The University of Tokyo) 2018 doi: 10.15083/00078262
- Akamatsu M., Yamashita T., Hirose N., Teramoto S., Kwak S. “The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.” Sci. Rep. 6:28649, 2016. doi: 10.1038/srep28649
- Hirose N., Uchida K., Matsunaga S., Chambers J.K., Nakayama H. “Expression of cell adhesion molecules in canine choroid plexus tumors.” J. Vet. Med. Sci. 77:255-9, 2015. doi: 10.1292/jvms.14-0381
- Hirose N., Uchida K., Kanemoto H., Ohno K., Chambers J.K., Nakayama H. “A retrospective histopathological survey on canine and feline liver diseases at the University of Tokyo between 2006 and 2012.” J. Vet. Med. Sci. 76:1015-20, 2014. doi: 10.1292/jvms.14-0083
Presentation
2025
- Hirose N., Teramoto S., Yamashita T., Aizawa H., Kwak S. “Aberrant decrement of multiple transcription factors regulating expression of the ADAR2 gene ADARB1 observed in the spinal and cortical motor neurons of sporadic ALS patients” The 48th Annual Meeting of the Japan Neuroscience Society (25/Jul/2025, Niigata City) Poster
2024
- Hirose N., Teramoto S., Yamashita T., Aizawa H., Kwak S. “Aberrant decrement of multiple transcription factors regulating expression of the ADAR2 gene ADARB1 underlies the death of the spinal motor neurons of sporadic ALS patients” The 47th Annual Meeting of the Molecular Biology Society of Japan (27/Nov/2024, Fukuoka City) Poster
2023
- Hirose N., Nakao K., Takata A. “Genome-wide identification of quantitative trait loci of transcriptional noise (tnQTL) for psychiatric disorder genomics” The 46th Annual Meeting of the Japan Neuroscience Society (1/Aug/2023, Sendai City) Poster
2022
- Hirose N., Teramoto S., Yamashita T., Aizawa H., Kwak S. “Aberrant decrement of certain transcription factors regulating the ADAR2 gene ADARB1 underlies the pathogenic downregulation of ADAR2 in the spinal motor neurons of sporadic ALS patients” The 45th Annual Meeting of the Molecular Biology Society of Japan (1/Dec/2022, Makuhari City) Poster & Science Pitch
- Hirose N., Nakao K., Takata A. “Genome-wide identification of quantitative trait loci of transcription noise (tnQTL) for psychiatric disorder genomics” The 45th Annual Meeting of the Molecular Biology Society of Japan (1/Dec/2022, Makuhari City) Poster
2021
- Hirose N., Teramoto S., Yamashita T., Aizawa H., Kwak S. “Aberrant expression of transcription factors may underlie the downregulation of ADAR2 in the spinal motor neurons of sporadic ALS patients” The Pan-Asian Consortium for Treatment and Research in ALS 2021 (2021/9/17, Online) Poster
2020
- Hirose N., Ema M., Sasaki E., Gusev O., Kawai J., Murakawa Y., Kawaji H. “Transcriptome atlas of fetal, infant, matured and aged non-human primates” The 43rd Annual Meeting of the Molecular Biology Society of Japan (3/Dec/2020, Online) Oral
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” International Plant & Animal Genome XXVIII (13/Jan/2020, San Diego, CA) Poster
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” International Plant & Animal Genome XXVIII (12/Jan/2020, San Diego, CA) Oral (invited)
2019
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” 30th International Conference on Genome Informatics (10/Dec/2019, The University of Sydney, Australia) Poster
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” The 42nd Annual Meeting of the Molecular Biology Society of Japan (6/Dec/2019, Fukuoka City) Oral
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” Genome Informatics (7/Nov/2019, CSHL, NY) Poster
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” The Non-Coding of Genome (16/Oct/2019, EMBL, Germany) Poster
- Hirose N., Teramoto S., Yamashita T., Kwak S. “Investigation on transcription factors that may regulate ADAR2 expression in human spinal motor neurons: an implication for mechanisms underlying sporadic ALS pathogenesis.” The 42nd Annual Meeting of the Japan Neuroscience Society (26/Jul/2019, Niigata City) Poster
- Hirose N., Murakawa Y., Kawaji H., Kawai J. “Development of a genome and RNA database of primates for nucleic acid-based drugs” The 5th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan (11/Jul/2019, Suita City) Poster
- Hirose N., Ema M., Sasaki E., Kawai J., Murakawa Y., Kawaji H. “Functional annotation of non-coding genomic regions in non-human primates” The Biology of Genomes (9/May/2019, CSHL, NY) Poster
2018
- Hirose N., Sano H., Yagi K., Okazaki Y., Watanabe T., Inoue T., Sasaki E., Nakaya M., Tsukiyama T., Seita Y., Ema M., Murakawa Y., Kawaji H., Kawai J. “Transcriptomic analysis of non-human primates’ tissues” The 41st Annual Meeting of the Molecular Biology Society of Japan (28/Nov/2018, Yokohama City) Poster
- Hirose N., Teramoto S., Yamashita T., Kwak S. “Tissue- and species-dependent difference in the regulation of ADAR2 expression: an implication for mechanisms underlying sporadic ALS pathogenesis.” The 41st Annual Meeting of the Japan Neuroscience Society (28/Jul/2018, Kobe City) Poster
- Hirose N., Naito Y., Murakawa Y., Kawai J., Kawaji H. “Prototype of mRNA/pre-mRNA/lncRNA/pre-lncRNA database for nucleic acid-based drugs” The 4th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan (10/Jul/2018, Fukuoka City) Poster
Database
- Database for drug development based on genome & RNA sequences D3G https://d3g.riken.jp/
Commercial magazine (Japanese)
- Hirose N., Kawaji H. “Gene model and genome & RNA database for nucleic acid drug development” Bioscience & Industry 78:142-5, 2020
- Hirabayashi S., Hirose N., De hoon M. “miRNA expression in health and disease” Igaku no Ayumi 269:267-71, 2019
- Hirose N., Kawai J., Kawaji H. “Databases for development of oligonucleotide therapeutics” Jikken Igaku 37:40-6, 2019
- Hirose N., Kawaji H. “Databases for sequences and expression of non-coding RNAs” Igaku no Ayumi 267:603-8, 2018
- Uchida K., Hirose N., Nibe K. “Pathology of liver tumors” Joncol 10:13-7, 2014
Book (Japanese)
- Kasai N. (translation support) “Laboratory Animal Anaesthesia and Analgesia (5th ed)” Dec, 2023 ISBN 978-4-910513-16-4
Grant
- KAKENHI Grant-in-Aid for Early-Career Scientists “Investigation into the molecular cascade of death of the upper motor neurons in amyotrophic lateral sclerosis” (PI; FY2025〜FY2027)
- The Yukihiko Miyata Memorial Trust for ALS Research” “Investigation into the molecular mechanisms of ADAR2 down-regulation in spinal motoneurons in sporadic amyotrophic lateral sclerosis” (PI; FY2024)
- KAKENHI Grant-in-Aid for Early-Career Scientists “Investigation into psychiatric disorder-associated loci that influence transcriptional noises in dopaminergic neurons induced from human iPS cells” (PI; FY2022~2023)
Professional membership
- The Japan Neuroscience Society
- The Japanese Society of Veterinary Science
- Japanese Association for Laboratory Animal Medicine
- Japanese College of Laboratory Animal Medicine