業績

2022年

論文

• "Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy."
  Kondo T, Higo S, Shiba M, Kohama Y, Kameda S, Tabata T, Inoue H, Okuno S, Ogawa S, Nakamura S, Takeda M, Ito E, Li J, Liu L, Kuramoto Y, Lee JK, Takashima S, Miyagawa S, Sawa Y, Hikoso S, Sakata Y.
  Circulation: Genomic and Precision Medicine. 2022. Jul. 12. (2022).

  • DOI: 10.1161/CIRCGEN.121.003522
• "Editorial: Induced Pluripotent Stem Cell-Based Disease Modeling and Drug Discovery: Can We Recapitulate Cardiovascular Disease on a Culture Dish?"
  Yuasa S, Yazawa M, Lee JK
  Front. Cell Dev. Biol. 2022. Jan. 31. (2022).

  • DOI: 10.3389/fcell.2021.831304

2021年

論文

• "Protocol for Morphological and Functional Phenotype Analysis of hiPS-Derived Cardiomyocytes. (Chapter writing in "Pluripotent Stem-Cell Derived Cardiomyocytes" Edited by Yoshida Y)"
  Li J, Lee JK
  Methods Mol. Biol. 2021: 2320:91-100 (2021).

  • DOI: 10.1007/978-1-0716-1484-6_10
• "High-throughput drug screening system based on human induced pluripotent stem cell-derived atrial myocytes ? A novel platform to detect cardiac toxicity for atrial arrhythmias"
  Honda Y, Li J, Hino A, Tsujimoto S, Lee JK
  Front Pharmacol. 2021 Aug 3;12:680618 (2021).

  • DOI: 10.3389/fphar.2021.680618
• "Homogeneous 2D and 3D Alignment of Cardiomyocyte in Dilated Cardiomyopathy Revealed by Intravital Heart Imaging"
  Masuyama K, Higo T, Lee JK, Matsuura R, Jones I, Bakal C, Higo S, Morimoto S, Miyagawa S, Sawa Y, Sakata Y
  Sci. Rep. 2021 Jul 19;11(1):14698 (2021).

  • DOI: 10.1038/s41598-021-94100-z
• "Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes"
  Yasutake H, Lee JK, Hashimoto A, Masuyama K, Li J, Kuramoto Y, Higo S, Hikoso S, Hidaka K, Naito AT, Miyagawa S, Sawa Y, Komuro I, Sakata Y
  Sci. Rep. 2021 May 14;11(1):10351 (2021).

  • DOI: 10.1038/s41598-021-89603-8
• "Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal"
  Li J, Lee JK, Miwa K, Kuramoto Y, Masuyama K, Yasutake H, Tomoyama S, Nakanishi H, Sakata Y
  Front. Cell Dev. Biol. 2021 Feb 15 (2021).

  • DOI: 10.3389/fcell.2021.591754

2019年

論文

• "Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias"
  Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S, Hidaka K, Miyagawa S, Sawa Y, Komuro I, Sakata Y
  Front. Physiol. 2019 Jun 27 (2019).

  • DOI: 10.3389/fphys.2019.00818

2018年

論文

• "In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects"
  Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y
  Europace 2018 Mar 15 (2018).

  • DOI: 10.1093/europace/eux379
• "Generation of Fabry Cardiomyopathy Model for Drug Screening Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Female Fabry Patient"
  Kuramoto Y, Naito AT, Tojo H, Sakai T, Ito M, Shibamoto M, Nakagawa A, Higo T, Okada K, Yamaguchi T, Lee JK, Miyagawa S, Sawa Y, Sakata Y, Komuro I
  J Mol Cell Cardiol 2018 Aug;121:256-265 (2018).

  • DOI: 10.1016/j.yjmcc.2018.07.246
• "Phenotypic Screening Using Patient-derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy"
  Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I
  Int Heart J. 2018 Aug 11 (2018).

  • DOI: 10.1536/ihj.17-730

2017年

論文

• "Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimension assessment of the cardiac sympathetic network in cleared transparent murine hearts"
  Yokoyama T, Lee JK, Miwa K, Opthof T, Tomoyama S, Nakanishi H, Yoshida A, Yasui H, Iida T, Miyagawa S, Okabe S, Sawa Y, Sakata Y, Komuro I
  Plos One. 2017 Jul 28;12(7):e0182072, PMID: 28753665 (2017).

  • DOI: 10.1371/journal.pone.0182072
• "Pivotal role of non-cardiomyocytes in electromechanical and therapeutic potential of induced pluripotent stem cell-derived engineered cardiac tissue"
  Iseoka H, Miyagawa S, Fukushima S, Saito A, Masuda S, Yajima S, Ito E, Sougawa N, Takeda M, Harada A, Lee JK, Sawa Y
  Tissue Eng Part A. 2017 Jun 13, PMID: 28498040 (2017).

  • DOI: 10.1089/ten.TEA.2016.0535
• "DNA single-strand break-induced DNA damage response causes heart failure"
  Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa S, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I
  Nat Commun. 2017 Apr 24;8:15104, PMID: 28436431 (2017).

  • DOI: 10.1038/ncomms15104

2016年

論文

• "Activation of endothelial β-catenin signaling induces heart failure"
  Nakagawa A, Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I
  Sci Rep. 2016 May 5;6:25009, PMID: 27146149 (2016).

  • DOI: 10.1038/srep25009
• "Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes"
  Hashimoto A, Naito AT, Lee JK, Kitazume-Taneike R, Ito M, Yamaguchi T, Nakata R, Sumida T, Okada K, Nakagawa A, Higo T, Kuramoto Y, Sakai T, Tominaga K, Okinaga T, Kogaki S, Ozono K, Miyagawa S, Sawa Y, Sakata Y, Morita H, Umezawa A, Komuro I
  Int Heart J. 2016;57(1):112-7, PMID: 26673445 (2016).

  • DOI: 10.1536/ihj.15-376
• "A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology"
  Takanari H, Miwa K, Fu X, Nakai J, Ito A, Ino K, Honda H, Tonomura W, Konishi S, Opthof T, van der Heyden MA, Kodama I, Lee JK
  J Cell Physiol. 2016 Oct;231(10):2249-56, PMID: 26873862 (2016).

  • DOI: 10.1002/jcp.25342

2015年

論文

• "Regeneration of the Cardiac Conduction System by Adipose Tissue-Derived Stem Cells"
  Takahashi T, Nagai T, Kanda M, Liu ML, Kondo N, Naito AT, Ogura T, Nakaya H, Lee JK, Komuro I, Kobayashi Y
  Circ J. 2015;79(12):2703-12, PMID: 26411528 (2015).

  • DOI: 10.1253/circj.CJ-15-0400
• "Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload"
  Yano M, Akazawa H, Oka T, Yabumoto C, Kudo-Sakamoto Y, Kamo T, Shimizu Y, Yagi H, Naito AT, Lee JK, Suzuki J, Sakata Y, Komuro I
  Sci Rep. 2015 Nov 2;5:15857, PMID: 26522369 (2015).

  • DOI: 10.1038/srep15857
• "Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression"
  Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I
  Sci Rep. 2015 Sep 25;5:14453, PMID: 26571361 (2015).

  • DOI: 10.1038/srep14453
• "Centrifugal microfluidic platform for single-cell level cardiomyocyte-based drug profiling and screening"
  Espulgar W, Aoki W, Ikeuchi T, Mita D, Saito M, Lee JK, Tamiya E
  Lab Chip. 2015 Sep 7;15(17):3572-80, PMID: 26215661 (2015).

  • DOI: 10.1039/c5lc00652j
• "Optical microscopy imaging for the diagnosis of the pharmacological reaction of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs)"
  Ikeuchi T, Espulgar W, Shimizu E, Saito M, Lee JK, Dou X, Yamaguchi Y, Tamiya E
  Analyst. 2015 Oct 7;140(19):6500-7, PMID: 26309911 (2015).

  • DOI: 10.1039/c5an01144b
• "Pirfenidone Exhibits Cardioprotective Effects by Regulating Myocardial Fibrosis and Vascular Permeability in Pressure Overloaded Hearts"
  Yamagami K, Oka T, Wang Q, Ishizu T, Lee JK, Miwa K, Akazawa H, Naito AT, Sakata Y, Komuro I
  Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H512-22, PMID: 26055790 (2015).

  • DOI: 10.1152/ajpheart.00137.2015
• "Wnt/b-catenin signaling contributes to skeletal myopathy in heart failure via direct interaction with forkhead box o"
  Okada K, Naito A.T., Higo T, Nakagawa A, Shibamoto M, Sakai T, Hashimoto A, Kuramoto Y, Sumida T, Nomura S, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Morimoto S, Sakata Y, Shiojima I, Komuro I
  Circ Heart Fail. 2015 Jul;8(4):799-808, PMID: 26038536 (2015).

  • DOI: 10.1161/CIRCHEARTFAILURE.114.001958
• "Complement C1q-induced activation of b-catenin signalling causes hypertensive arterial remodeling"
  Sumida T, Naito A.T., Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I
  Nat Commun. 2015 Feb 26;6:6241, PMID: 25716000 (2015).

  • DOI: 10.1038/ncomms7241

2014年

論文

• "N-glycans: phenotypic homology and structural differences between myocardial cells and induced pluripotent stem cell-derived cardiomyocytes"
  Kawamura T, Miyagawa S, Fukushima S, Yoshida A, Kashiyama N, Kawamura A, Ito E, Saito A, Maeda A, Eguchi H, Toda K, Lee JK, Miyagawa S, Sawa Y
  PLoS One. 2014 Oct 30;9(10):e111064, PMID: 25357199 (2014).

  • DOI: 10.1371/journal.pone.0111064
• "Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix"
  Yasui H, Lee JK, Yoshida A, Yokoyama T, Nakanishi H, Miwa K, Naito AT, Oka T, Akazawa H, Nakai J, Miyagawa S, Sawa Y, Sakata Y, Komuro I
  Biomaterials. 2014 Sep;35(27):7839-50, PMID: 24952982 (2014).

  • DOI: 10.1016/j.biomaterials.2014.05.080
• "Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling"
  Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I
  J Biol Chem. 2014 Jul 11;289(28):19408-19, PMID: 24891510 (2014).

  • DOI: 10.1074/jbc.M114.567206
• "Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure"
  Oka T, Akazawa H, Naito AT, Komuro I
  Circ Res. 2014 Jan 31;114(3):565-71, PMID: 24481846 (2014).

  • DOI: 10.1161/CIRCRESAHA.114.300507

2013年

論文

• "Axon guidance of sympathetic neurons to cardiomyocytes by glial cell line-derived neurotrophic factor (GDNF)"
  Miwa K, Lee J, Takagishi Y, Opthof T, Fu X, Hirabayashi M, Watabe K, Jimbo J, Kodama I, Komuro I
  PLoS One. 2013 Jul 3;8(7):e65202, PMID: 23843937 (2013).

  • DOI: 10.1371/journal.pone.0065202

2012年

論文

• "Complement c1q activates canonical wnt signaling and promotesaging-related phenotypes"
  Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T,Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I,Komuro I
  Cell. 2012 Jun 8;149(6):1298-313, PMID: 22682250 (2012).

  • DOI: 10.1016/j.cell.2012.03.047

2011年

論文

• "Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice"
  Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I
  Mol Cell Biol. 2011 Mar;31(5):1054-65, PMID: 21189286 (2011).

  • DOI: 10.1128/MCB.00732-10

2010年

論文

• "The cellular prion protein identifies bipotential cardiomyogenic progenitors"
  Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, Morisaki T
  Circ Res. 2010 Jan 8;106(1):111-9, PMID: 19910576 (2010).

  • DOI: 10.1161/CIRCRESAHA.109.209478
• "Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury"
  Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
  Circ Res. 2010 Jun 11;106(11):1692-702, PMID: 20413784 (2010).

  • DOI: 10.1161/CIRCRESAHA.110.223776
• "Wnt signaling and aging-related heart disorders"
  Naito AT, Shiojima I, Komuro I
  Circ Res. 2010 Nov 26;107(11):1295-303, PMID: 21106946 (2010).

  • DOI: 10.1161/CIRCRESAHA.110.223776