RESULTS

Oncogene c-Myc promotes epitranscriptome m⁶A reader YTHDF1 expression in colorectal cancer (Oncotarget, in press)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Nishizawa et al. demonstrated that epitranscriptome N6-methyladenosine (m⁶A) reader, YT521-B homology YTH domain family YTHDF1,  plays a role in the malignant behavior of colorectal cancer cells in an oncogene transcription factor c-Myc  dependent manner. Given that the m⁶A was first reported in RNA modification and is most common in the epitranscriptome issues of various RNAs, the present study indicated that YTHDF1 may be involved in the translation of numerous tumor related proteins. We are exploring further the transcription and ribosomal translation mechanism of epitranscriptome dependent pathway in the tumor microenvironment such as hypoxia.