Research Group and Staff

The focus of our lab (iLAB) includes cancer stem cells. We are developing state-of-the-art techniques that study how these cells regulate cancer development and researching new drugs that can inhibit their effects. Our research covers the basic to clinical, but we seek to build new strategic approaches that take advantage of the academic environment. One major goal is to create an accurate human cancer model. This work involves rigorous study of a number of cancer topics, including the cancer metabolism, cancer stem cells, transomics, and new biomarkers and drugs. Of special interest is TAS 102, an anticancer drug being used in ongoing clinical trials, and its effect on cancer stem cells, but we extend the research to other broadly related reagents. This drug is classified as a nucleic acid drug, as it targets specific genes that are thought to regulate the cancer. Other research on drugs and biomarkers involves the investigation of miRNA and lncRNA. We are also studying the cancer metabolism to understand how cancer develops and progresses and ways to counter these events. One carbon metabolism, because of its role in DNA synthesis and DNA methylation, is thought to have an important role in cancer stem cells. We are looking at drugs and biomarkers that target one-carbon metabolism by studying interactions between the nucleus and mitochondria, RNA modomics, genome modification, editing and transomics. Finally, we are attempting to bring machine learning into our studies. Overall, our research depends on strong industry-university collaborations towards the precision medicine, such as early diagnosis and innovative treatment of deleterious diseases, in near future.

Member

Hideshi Ishii

Link >石井 秀始 [Hideshi Ishii]

Professor,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University

M.D., Ph.D.

石井 秀始 [Hideshi Ishii]

Specialized Area

  • ・Clinical Oncology, Drug Discovery, Medical Data Science

Academic Background & Research History

  • Apr, 1988 Graduate from Chiba University School of Medicine
  • May, 1988 Resident,
    Chiba University Hospital
  • Apr, 1989 Resident,
    Chiba Municipal Hospital
  • Sep, 1989 Resident,
    Chiba Hospital of Kawasaki Steel Corporation
  • Sep, 1992 Resarch Resident,
    National Cancer Center, Resarch Institute
  • Apr, 1995 Resarcher,
    National Institute of Radiological Sciences
  • Apr, 1996 Resarcher,
    Thomas Jefferson University, U.S.
  • Jan, 2001 Famulus,
    Sidney Kimmel Comprehensive Cancer Center, U.S.
  • Oct, 2001 Lecturer,
    Sidney Kimmel Comprehensive Cancer Center, U.S.
  • Oct, 2002 Lecturer,
    Jichi Medical University
  • Apr, 2008 Associate Professor,
    Kyushu University
  • Apr, 2011 Professor,
    Department of Frontier Science for Cancer and Chemotherapy,
    Graduate School of Medicine, Osaka University
  • Apr, 2014 Professor,
    Department of Cancer Profiling Discovery,
    Graduate School of Medicine, Osaka University
  • Apr, 2017 Professor,
    Department of Medical Data Science Graduate School of Medicine, Osaka University
  • Jan, 2015 Guest Researcher,
    RIKEN Center for Integrative Medical Sciences

原 知明 [Tomoaki Hara]

Assistant Professor,

Department of Medical Data Science Graduate School of Medicine, Osaka University

Ph.D.

原 知明 [Tomoaki Hara]

Specialized Are

  • ・RNA science

Academic Background & Research History

  • Mar, 2008Graduate from Department of Science, Faculty of Science, Kyoto University
  • May, 2013Kyoto University Graduate School of Life Science Ph.D.
  • Apr, 2013Researcher, Yakult Honsha Co., Ltd.
  • Jan, 2016Assistant Professor, Okayama University Graduate School of Natural Science and Technology
  • Apr, 2017Researcher, RIKEN Center for Developmental Biology
  • Sep, 2017Researcher, Research Institute of Innovative Technology for the Earth, Molecular Microbiology and Biotechnology Group
  • Apr, 2021Public Officer, Department of Environment, Agriculture, Forestry and Fisheries, Osaka prefectural office
  • Jan, 2022Researcher, Nagoya University Graduate School of Science
  • Sep, 2022Assistant Professor, Department of Medical Data Science Graduate School of Medicine, Osaka University

research field

  • ・RNA, chemical modification, intractable disease (pancreatic cancer)

self-introduction

  • I got a degree in RNA and RNA-binding protein-related research. After that, engaged in microbial-related research, RNA-binding protein-related research, and RNA research at a company, research institutes, and universities. I join this lab in order to take on the challenge of cancer research by making the most of my experience.

resolution

  • I appreciate participating in cancer research as a member of this lab. With “RNA” as a keyword, I will devote myself to new discoveries that can be used in the diagnosis and treatment of cancer from the analysis of big data, which is the strength of this lab.

Management General

Chihiro Ohtsuka

Graduate School of Medicine, Osaka University

Expert Technician

Miyuki Ozaki

Graduate School of Medicine, Osaka University


Yuko Noguchi

Graduate School of Medicine, Osaka University

Academia Consortium

Masaki Mori

Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Yuichiro Doki

Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Koshi Mimori

Professor,
Department of Surgery, Kyushu University Beppu Hospital

Hidetoshi Matsui

Associate Professor,
Center for Data Science Education and Research, Shiga University

Clinical Consortium

Taroh Satoh

Professor,
Graduate School of Medicine, Osaka University

Toshihiro Kudo

Assistant Professor,
Graduate School of Medicine, Osaka University

Daisuke Sakai

Assistant Professor,
Graduate School of Medicine, Osaka University

Graduate Students

― D4 ―

Kenta Tsunekuni

Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Research Scientist, Laboratory for Oncology Medication Management and Development, TAIHO PHARMACEUTICAL CO., ITD.

Reishi Toshiyama

Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

西沢祐次郎(Yujiro Nishizawa)

大阪大学大学院 医学系研究科 消化器外科

Kosuke Taketo

Department of Radiation Oncology,
Graduate School of Medicine, Osaka University

― D3 ―

Yuji Takaoka

大阪大学大学院 医学系研究科  放射線治療学講座

Matsushita Katsunori

大阪大学大学院 医学系研究科 消化器外科

― D2 ―

Kiminori Yanagisawa

大阪大学大学院 医学系研究科 消化器外科

Yuji Ueda

大阪大学大学院 医学系研究科 消化器外科

Masayasu Toratani

大阪大学大学院 医学系研究科  放射線治療学講座

Graduates

Katsuya Ohta

Yoshihiro Kano

Shimpei Nishikawa

Atsushi Hamabe

Shinichiro Hasegawa

Hisataka Ogawa

Takahito Fukusumi

Kazuhiko Hayashi

Keisuke Tamari

Masaaki Miyo

Kozo Noguchi

Kei Asukai

Tomofumi Ohashi

Tsuyoshi Hata

Toshinori Sueda

白 成栽

Hugh Colvin