Research Group and Staff
The focus of our lab (iLAB) includes cancer stem cells. We are developing state-of-the-art techniques that study how these cells regulate cancer development and researching new drugs that can inhibit their effects. Our research covers the basic to clinical, but we seek to build new strategic approaches that take advantage of the academic environment. One major goal is to create an accurate human cancer model. This work involves rigorous study of a number of cancer topics, including the cancer metabolism, cancer stem cells, transomics, and new biomarkers and drugs. Of special interest is TAS 102, an anticancer drug being used in ongoing clinical trials, and its effect on cancer stem cells, but we extend the research to other broadly related reagents. This drug is classified as a nucleic acid drug, as it targets specific genes that are thought to regulate the cancer. Other research on drugs and biomarkers involves the investigation of miRNA and lncRNA. We are also studying the cancer metabolism to understand how cancer develops and progresses and ways to counter these events. One carbon metabolism, because of its role in DNA synthesis and DNA methylation, is thought to have an important role in cancer stem cells. We are looking at drugs and biomarkers that target one-carbon metabolism by studying interactions between the nucleus and mitochondria, RNA modomics, genome modification, editing and transomics. Finally, we are attempting to bring machine learning into our studies. Overall, our research depends on strong industry-university collaborations towards the precision medicine, such as early diagnosis and innovative treatment of deleterious diseases, in near future.
Member
Hideshi Ishii
Link >石井 秀始 [Hideshi Ishii]
Professor,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University
M.D., Ph.D.
Specialized Area
- ・Clinical Oncology, Drug Discovery, Medical Data Science
Academic Background & Research History
- Apr, 1988 Graduate from Chiba University School of Medicine
- May, 1988
Resident,
Chiba University Hospital - Apr, 1989
Resident,
Chiba Municipal Hospital - Sep, 1989
Resident,
Chiba Hospital of Kawasaki Steel Corporation - Sep, 1992
Resarch Resident,
National Cancer Center, Resarch Institute - Apr, 1995
Resarcher,
National Institute of Radiological Sciences - Apr, 1996
Resarcher,
Thomas Jefferson University, U.S. - Jan, 2001
Famulus,
Sidney Kimmel Comprehensive Cancer Center, U.S. - Oct, 2001
Lecturer,
Sidney Kimmel Comprehensive Cancer Center, U.S. - Oct, 2002
Lecturer,
Jichi Medical University - Apr, 2008
Associate Professor,
Kyushu University - Apr, 2011
Professor,
Department of Frontier Science for Cancer and Chemotherapy,
Graduate School of Medicine, Osaka University - Apr, 2014
Professor,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University - Apr, 2017
Professor,
Department of Medical Data Science Graduate School of Medicine, Osaka University - Jan, 2015
Guest Researcher,
RIKEN Center for Integrative Medical Sciences
原 知明 [Tomoaki Hara]
Assistant Professor,
Department of Medical Data Science Graduate School of Medicine, Osaka University
Ph.D.
Specialized Are
- ・RNA science
Academic Background & Research History
- Mar, 2008Graduate from Department of Science, Faculty of Science, Kyoto University
- May, 2013Kyoto University Graduate School of Life Science Ph.D.
- Apr, 2013Researcher, Yakult Honsha Co., Ltd.
- Jan, 2016Assistant Professor, Okayama University Graduate School of Natural Science and Technology
- Apr, 2017Researcher, RIKEN Center for Developmental Biology
- Sep, 2017Researcher, Research Institute of Innovative Technology for the Earth, Molecular Microbiology and Biotechnology Group
- Apr, 2021Public Officer, Department of Environment, Agriculture, Forestry and Fisheries, Osaka prefectural office
- Jan, 2022Researcher, Nagoya University Graduate School of Science
- Sep, 2022Assistant Professor, Department of Medical Data Science Graduate School of Medicine, Osaka University
research field
- ・RNA, chemical modification, intractable disease (pancreatic cancer)
self-introduction
- I got a degree in RNA and RNA-binding protein-related research. After that, engaged in microbial-related research, RNA-binding protein-related research, and RNA research at a company, research institutes, and universities. I join this lab in order to take on the challenge of cancer research by making the most of my experience.
resolution
- I appreciate participating in cancer research as a member of this lab. With “RNA” as a keyword, I will devote myself to new discoveries that can be used in the diagnosis and treatment of cancer from the analysis of big data, which is the strength of this lab.
Management General
Chihiro Ohtsuka
Graduate School of Medicine, Osaka University
Expert Technician
Miyuki Ozaki
Graduate School of Medicine, Osaka University
Yuko Noguchi
Graduate School of Medicine, Osaka University
Academia Consortium
Masaki Mori
Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University
Yuichiro Doki
Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University
Koshi Mimori
Professor,
Department of Surgery, Kyushu University Beppu Hospital
Hidetoshi Matsui
Associate Professor,
Center for Data Science Education and Research, Shiga University
Clinical Consortium
Taroh Satoh
Professor,
Graduate School of Medicine, Osaka University
Toshihiro Kudo
Assistant Professor,
Graduate School of Medicine, Osaka University
Daisuke Sakai
Assistant Professor,
Graduate School of Medicine, Osaka University
Graduate Students
― D4 ―
Kenta Tsunekuni
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University
Research Scientist, Laboratory for Oncology Medication Management and Development, TAIHO PHARMACEUTICAL CO., ITD.
Reishi Toshiyama
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University
西沢祐次郎(Yujiro Nishizawa)
大阪大学大学院 医学系研究科 消化器外科
Kosuke Taketo
Department of Radiation Oncology,
Graduate School of Medicine, Osaka University
― D3 ―
Yuji Takaoka
大阪大学大学院 医学系研究科 放射線治療学講座
Matsushita Katsunori
大阪大学大学院 医学系研究科 消化器外科
― D2 ―
Kiminori Yanagisawa
大阪大学大学院 医学系研究科 消化器外科
Yuji Ueda
大阪大学大学院 医学系研究科 消化器外科
Masayasu Toratani
大阪大学大学院 医学系研究科 放射線治療学講座