c-Met affects gemcitabine resistance in mouse model of pancreatic cancer (Oncology Letters, 2016 )
In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Noguchi et al. studied a mouse Kras/Met model of pancreatic cancer stem cells (CSCs) and showed that c-Met inhibition in Kras mice significantly decreased pancreatic intraepithelial neoplasia (PanIN) lesions, suggesting that complete c-Met signal inhibition with chemotherapy could be useful for control of pancreatic malignant features.