RESULTS

c-Met affects gemcitabine resistance in mouse model of pancreatic cancer (Oncology Letters, 2016 )
In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Noguchi et al. studied a  mouse Kras/Met   model of pancreatic cancer stem cells (CSCs) and  showed that  c-Met inhibition in Kras mice significantly decreased pancreatic intraepithelial neoplasia (PanIN)  lesions, suggesting that complete c-Met signal inhibition with chemotherapy could be useful for control of pancreatic malignant features.