A) The cytokine-induced dimerization of the receptor induces tyrosine-phosphorylation of the cytokine receptor by JAK. STAT is recruited on the receptor in a manner that is dependent on the interaction between the SH2 domain of STAT and the tyrosine-phosphorylated specific docking site on the receptor. B) Cytokine-induced dimerization of the receptor induces the activation of JAK, which can phosphorylate STAT in a manner that is dependent on the interaction between the JH2 domain of JAK and STAT.
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