Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Suematsu-S; Matsusaka-T; Matsuda-T; Ohno-S; Miyazaki-J; Yamamura-K; Hirano-T; Kishimoto-T, Proc-Natl-Acad-Sci-U-S-A.
The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.
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