山中庸次郎

昭和62年3月　神奈川県立湘南高等学校　卒業

平成3年3月　北海道大学薬学部薬学科　卒業

平成5年3月　北海道大学大学院薬学研究科修士課程修了

平成9年3月　大阪大学大学院医学研究科博士課程修了（腫瘍病理）　

平成10年4月　大阪大学医学部腫瘍病理助手

The Rossant Lab Mount Sinai Hospital 600 University Ave., rm 884Toronto, Ontario M5G1X5 CANADA

Publication List

19) Ryu, S.-L., Y. Yamanaka, T. Shimizu, R. Fujii, T. Yabe, T. Hirata, M. Hibi, and T. Hirano. Regulation of dharma/bozozok by the Wnt pathway. submitted.

18) Hashimoto, H., T., Yabe, T. Hirata, T. Shimizu, Y.-K. Bae, Y. Yamanaka, T. Hirano, and M. Hibi. Expression of the zinc finger gene fez-like in zebrafish forebrain. Mechanisms of Development, 97:191-195, 2000 (PubMed)

17) Hirata, T., Y. Yamanaka, S.-L. Ryu, T. Shimizu, T. Yabe, M. Hibi, and T. Hirano. Novel mix-family homeobox genes in zebrafish and their differential regulation. BBRC, 271:603-609, 2000.(PubMed).

16) Shimizu, T., Y. Yamanaka, S.-L. Ryu, H. Hashimoto, T. Yabe, T. Hirata, Y.-K. Bae, M. Hibi, and T. Hirano. Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mechanisms of Development, 91, 293-303, 2000.(Full Text)(PubMed)

15) Hashimoto, H., M. Itoh, Y. Yamanaka, S. Yamashita, T. Shimizu, L. Solnica-Krezel, M. Hibi, and T. Hirano. Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation. Developmental Biology 217, 138-152, 2000.(Abstract)(PubMed)

14) Fekany, K., Y. Yamanaka, T. Leung, H. I. Sirotkin, J. Topczewski, M. A. Gates, M. Hibi, A. Renucci, D. Stemple, A. Radbill, A. F. Schier, W. Driver, T. Hirano, W. S. Talbot, and L. Solnica-Krezel. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development, 126:1427-1438, 1999. (Development), (PubMed)

13) Yamanaka, Y., T. Mizuno, Y. Sasai, M. Kishi, H. Takeda, C.-H. Kim, M. Hibi and T. Hirano. A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes & Development, 12: 2345-2353, 1998.(Abstract)(PubMed) (Full Text in G & D)　(研究課題)

12) Takahashi-Tezuka*, M., Y. Yoshida*, T. Fukada, T. Yamaguchi, Y. Yamanaka, K. Nakajima, M. Hibi, and T. Hirano. Gab1 acts as an adaptor molecule linking a cytokine receptor gp130 to ERK MAP kinase. Mol. Cell. Biol. 18:4109-4117, 1998. (equal contribution of the first two authors*) (PubMed)(Full Text in MCB)

11) Ichiba, M., K. Nakajima, Y. Yamanaka, N. Kiuchi and T. Hirano Autoregulation of the Stat3 gene through cooperation with a CRE site binding protein. J. Biol. Chem. 273:6132-6138, 1998 (PubMed)

10) Kim, C.-H., Y.-K. Bae, Y. Yamanaka, S. Yamashita, T. Shimizu, R. Fujii, H.-C. Park, S.-Y. Yeo, T.-L. Huh, M. Hibi, and T. Hirano. Overexpression of neurogenin induces extopic expression of HuC in zebrafish. Neuroscience Letters 239:113-116, 1997.(PubMed)

9) Yamanaka, Y., K. Nakajima, T. Fukada, M. Hibi, and T. Hirano. Differentiation and growth arrest signals generate through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J. 15:1557-1565, 1996. (Abstract) (PubMed)

8)Fujitani, Y., M. Hibi, T. Fukada, M. Takahashi-Tezuka, H. Yoshida, T. Yamaguchi, K. Sugiyama, Y. Yamanaka, K. Nakajima, and T. Hirano. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene, 14: 751-761, 1997. (Abstract)

7) Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka, Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5: 449-460, 1996. (Abstract) (Immunity on line for Full TEXT)

6) Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, N. Kiuchi, M. Ichiba, T. Kitaoka, T. Fukada, M. Hibi and T. Hirano. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15:3651-3658, 1996. (Abstract)(PubMed)

5) Nakajima, K., T. Matsuda, Y. Fujitani, H. Kojima, Y. Yamanaka, K. Nakae, T. Takeda and T. Hirano. Signal transduction through IL-6 receptor: involvement of multiple protein kinases, Stat factors and a novel H-7-sensitive pathway. Ann. New York Acad. Sci. 762: 55-70, 1995.

4) Matsuda, T., Y. Yamanaka, and T. Hirano. Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells. Biochem. Biophys. Res. Comm. 200: 821-828, 1994.
Pabulication

3) Nomura, Y., Y. Kitamura, T. Ohnuki, T. Arima, Y. Yamanaka, K. Sasaki, and Y. Oomura. Alterations in acetylcholine, NMDA, benzodiazepine receptors and protein kinase C in the senescence-accelerated mouse: an animal model useful for studies on cognitive enhancers. Behavioural Brain Res. 83:51-55,1997.

2) Kitamura, Y., A. Miyazaki, Y. Yamanaka, and Y. Nomura. Stimulatory effects of protein kinase C and calmodulin kinaseII on N-methyl-D-aspartate receptor/channels in the post synaptic density of rat brain J.Neurochem. 61:100-109,1993.

1)　Nomura, Y., Y. Yamanaka, Y. Kitamura, T. Arima, T. Ohnuki, Y. Oomura, K. Sasaki, K. Nagashima, and Y. Ihara. Senescence-accelerated mouse: Neurochemical study on aging. Ann. New York Acad. Sci. 786:410-418,1996