- Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease
Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN, Sadik GM, Takeda M
Acta Neurol Taiwan 15:68-71, 2006
- Presenilin-dependent ƒÁ-secretase on plasma membrane and endosomes is functionally distinct
Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
Biochemistry 45(15);4907-14, 2006
- Altered localization of amyloid precursor protein under endoplasmic reticulum stress
Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D,Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
Biochem Biophys Res Commun344:525-530,2006
- Hyperactivation of Midbrain Dopaminergic System in Schizophrenia could be attributed to the Down-regulation of Dysbindin
Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M
Biochem Biophys Res Commun 345;904-909, 2006
- Cognitive impairment in patients with idiopathic normal pressure hydrocephalus
Ogino A, Kazui H, Miyoshi N, Hashimoto M, Ohkawa S, Tokunaga H, Ikejiri Y, Takeda M
Dement Geriat Cogn Disord 21(2);113-9, 2006
- Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and Dementia with Lewy bodies in Japan
Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K
Dementia Geriat Cog Disod 22;216-222, 2006
- Right parietal activation during delusional state in episodic interictal psychosis of epilepsy; A report of two cases
Ishii R, Canuet L, Iwase M, Kurimoto R, Ikezawa K, Robinson SE, Ukai S, Shinosaki K, Hirata M, Yoshimine T, Takeda M
Epilepsy Behav 9(2);367-72 2006
- Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling
Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H
Hum Mol Genet 15(20);3024-3033, 2006
- A possible association between the-116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T
Int J Neuropsychopharmacol, 8;1-6, 2005
- Effect of linearization correction on statistical parametric mapping (SPM); A 99mTc-HMPAO brain perfusion SPECT study in mild Alzheimer's disease
Ansar MAB, Osaki Y, Kazui H, Oku N, Takazawa M, Kimura Y, Begum NN, Ikejiri Y, Takeda M, Hatazawa
J Annals of Nuclear Medicine 20(8) :511-517, 2006
- Formation of Tau Inclusions in Knock-in Mice with Familial Alzheimer Disease (FAD) Mutation of Presenilin 1 (PS1)
K Tanemura, Du-Hua Chui, T Fukuda, M Murayama, Jung-Mi Park, T Akagi, Y Tatebayashi, T Miyasaka, T Kimura, T Hashikawa, Y Nakano, T Kudo, M Takeda, A Takashima
J Biol Chem 281(8); 5037-5041, 2006
- Secretion of the Notch-1 AƒÀ-like peptide during Notch signaling
Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M
J Biol Chem 281(12);7890-8, 2006
- Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease
Kazui H, Hashimoto M, Nakao Y, Matsumoto K, Takatsuki Y, Mori E, Ikejiri Y, Takeda M
J Geriatric Neurol 19(1);3-12, 2006
- Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus
Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H
J Neural Transm 113;1337-1346, 2006
- Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O
J Neural Transm 113;1569-1573, 2006
- Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzhiemer's disease
K. Nakamura, W. Ohya, H Funakoshi, G Sakaguchi, A Kato, M Takeda, Tkudo, T Nakamura
J Neurocie Res 84,874-890,2006
- Actions anchored by concepts; defective action comprehension in semantic dementia
Nishio Y, Kazui H, Hashimoto M, Shimizu K, Onouchi K, Mochio S, Suzuki K, Mori E
J Neurol Neurosurg Psychiatry77(12):1313-1317,2006
- Polymorphism of the regulatory region of the presenilin-2 gene in sporadic
Alzheimer's disease; a case-control study
Quan W, Yasuda M, Hashimoto M, Yamamoto Y, Ishii K, Kazui H, Mori E, Kakigi T,Maeda K
J Neurol Sci 240;71-75, 2006
- Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice
Tanaka K, Shintani N, Hashimoto H,
Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A
J Neurosci 26(19);5091-5097,2006
- Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain
Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
J Neurosci Res 84(4);918-25,2006
- The protease active site domain of secretase contributes to substrate identification
Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
J Neurosci 26(14);3821-8,2006
- A novel alternative splice variant of nicastrin and its implication in Alzheimer disease
Mitsuda N, Yamagata HD, Zhong W, Aoto M, Akatsu H, Uekawa N, Kamino K, Taguchi K, Yamamoto T, Maruyama M, Kosaka K, Takeda M, Kondo I, Miki T
Life Sci 78 (21);2444-8, 2006
- A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H
Mol Psychiatry 11;1-9, 2006
- Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM
Nat Neurosci 9(2);234-42,2006
- Development of new screening system for Alzheimer disease, in vitro AƒÀ sink assay,
to identify the dissociation of soluble AƒÀfrom
fibrils
Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T,Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
Neurobiol Dis 22(3);487-95.,2006
- Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese "shiritori" word generation task
Yamamoto M, Ukai S, Shinosaki K, Ishii R, Kawaguchi S, Ogawa A, Mizuno-Matsumoto Y, Fujita N, Yoshimine T, Takeda M
Neuropsychobiology 53;215-222 2006
- The Val66Met polymorphism of the BDNF gene affects age-related brain morphology
Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H
Neurosci Lett 397;25-29, 2006
- Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR
Proc Natl Acad Sci USA, 103(17);6747-6752, 2006
- Susceptibility genes for schizophrenia
Hashimoto R, Hattori S, Chiba S, Yagasaki Y, Okada T, Kumamaru E, Mori T, Nemoto K, Tanii H, Hori H, Noguchi H, Numakawa T, Ohnishi T, Kunugi H
Psychiatry Clin Neurosci 60;S4-S10, 2006
- Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells
Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M
Psyichiat Clin Neurosci 60; S27-S33, 2006
- Albumin gene encoding free fatty acid and ƒÀ-amyloid transporter is genetically associated with Alzheimer disease
Kimura R, Kamino K, Yamamoto M, Akatsu H, Uema T, Kobayashi T, Hattori H, Nuripa A, Nessa B, Kudo T, Yamagata H, Miki T, Takeda M
Psyichiat Clin Neurosci 60; S34-S39, 2006
- Neural substrates of emotional habituation; A PET study using film stimuli
Hatta N, Nishikawa T, Ikejiri Y, Tokunaga H, Masaki Y, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M
Psychiatry Clin Neurosci. 60 Suppl 1;S40-45,2006
- Neural substrates of emotionally valenced episodic memory; A PET study using film stimuli
Masaki Y, Nishikawa T, Ikejiri Y, Tokunaga H, Hatta N, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M
Psychiatry Clin Neurosci 60 Suppl 1;S46-51, 2006
- Discrepancy of perforamance among working memory-related tasks in autism spectrum disorders was caused by task charactereistics, apart from working memory, which could interfere with task execution
T Nakahachi, M Iwase, H Takahashi, E Honaga, W Ishigami, O Kajimoto, K Yamashita, R Hashimoto, H Tanii, A Shimizu, M Takeda
Psychiat Clin Neurosci 60, 312-318, 2006
- Lithium response and Val66Met polymorphism of the BDNF gene in Japanese patients with bipolar disorder
Masui T, Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T
Psychiatr Genet 16(2);49-50, 2006
- Multiple anti-Alzheimer disease activities of non-steroidal anti-inflammatory drugs
Morihara T, Cole GM, Tanii H, Tanaka T, Kudo T, Takeda M
Psychogeriatrics 6(1);1-3,2006
- AƒÀinduces endoplasmic reticulum stress causing possible proteasome impairment via the encoplasmic reticulum-associated degradation pathway
Kanayama D, Kudo T, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, Takeda M
Psychogeriatrics 6;100-106, 2006
- Inhibition of endocytosis activates alternative degradation pathway of ƒÀAPP in cultured cells
Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Ito N, Tagami S, Okochi M, Takeda M
Psychogeriatrics 6;107-113, 2006
- Neuropsychological test for the detection in elderly individuals;the Nishimura Dementia Test
T Fukunaga,S Ukai,T Kobayashi,T Nishimura,M Takeda
Psychogeriatrics.6;159-167,2006
- Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M , Takeda M
Psychogeriatrics 6(Suppl 2); S57-S63,2006
- Antipsychotic medication and cognitive function in schizophrenia
Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H
Schizophr Res 86;138-146,2006
- Change of cleavage precision by Presenilin-dependent gamma-secretase
Okochi M. Tagami S, Takeda M
Alzheimer's and Dementia;The Journal of the Alzheimer's association 2(3)Suppl 1 S11,2006
- Presenilin-dependent gamma-secretases on plasma membrane and endosomes are functionally distinct
Fukumori A, Okochi M,Jingwei J, Ikuta A, Yanagida K, Nakayama T, Katsura Y, Mori K, Hong Tao, Morihara T,,Kamino K, Tanaka T, Kudo T, Steiner H, Haass C, Tagami S,Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S446,2006
- Effects of nitration of PS/gamma-secretase
Mori K, Okochi M, Fukumori A, Jingwei J, Ikuta A, Yanagida K, Nakayama T, Katsura Y, Hong Tao, Morihara T, Kamino K, Tanaka T, Kudo T, Tagami S, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S447,2006
- Amyloid-beta generation and degradation by BACE1
Ikuta A, Tagami S, Jingwei J, Yanagida K, Nakayama T, Katsura Y, Mori K, Hong Tao, Morihara T, Kamino K, Tanaka T, Kudo T, Steiner H, Haass, C, Okochi, M, Takeda, M.
Alzheimer's and Dementia;The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
- Inhibition of amyloid-beta production is possible without directly affecting secretases and Notch signaling
Yanagida, K, Okochi M, Ito N, Nishitomi K, Sakaguchi G, Kato A, Fukumori A, Jingwei J, Ikuta A, Nakayama T, Morihara T, Kamino, K, Tanaka T, Kudo T, Katsura Y, Hong Tao, Mori K, Tagami S, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
- Characterization of The Notch-1 amyloid-ƒÀ like peptides
Katsura Y, Okochi M, Fukumori A, Ito N, Jingwei J, Ikuta A, Yanagida K, Nakayama T, Morihara T, Kamino K, Tanaka T, Kudo, T, Hong Tao, Mori K, Tagami S, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S449,2006
- Comparison of S3 cleavage of Notch-1 with ƒÃ-cleavage of ƒÀAPP by presenilin/ƒÁ-secretase
Tagami S, Okochi M, Fukumori A, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S494,2006
- Inhibition of endocytosis activates alternative degradation pathway of bAPP in cultured cells
Hong Tao, Oguri T, Okochi M, Fukumori A, Jingwei J, Ikuta A., Yanagida K, Nakayama T, Katsura Y, Mori K, Morihara T, Kamino K, Tanaka T, Kudo T, Tagami S, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S528,2006
- Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/ƒÁ-secretase cleavage
Nakayama T, Okochi M, Ito N, Nishitomi K, Baba T, Sakaguchi G, Kato A, Fukumori A, Jingwei J, Ikuta A, Yanagida K, Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Hong Tao, Mori K, Tagami S, Takeda M
Alzheimer's and Dementia; The Journal of the Alzheimer's association 2(3)Suppl 1 S600,2006
- Brain functional reaction under emotional stimulation related with mental stability
Mizuno-Matsumoto Y, Nakao M, Ishii R, Ukai S, Kaishima T, Shinosaki K
NeuroImage 31 Suppl 1 101 T-AM 2006
- SAM(G2) Analysis; A New Approach for MEG Source Localization of Epilepsy
Ishii R, Robinson SE, Iwase M, Canuet L, Kurimoto R, Ikezawa K, Azechi M, Ukai S, Yoshimine T, Shinosaki K, Takeda M
Neuropsychobiology 54;29-30 2006
- Working memory in pervasive developmental disorders-Comparison of advanced trail making test, digit symbol and digit span
Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai A, Ishii R, Ishigami W, Kajimoto O, Hashimoto R, Yamashita K, Shimizu A, Takeda M
Psychiatry and Clinical Neurosciences 60, A2, 2006
- MEG study of an epileptic patient with colored visual auras
Ukai S, Ishii R, Kawaguchi S, Yamamoto M, Ogawa A, Mizuno Y, Fujita N, Yoshimine T, Shinosaki K, Takeda M
Psychiat and Clin Neurosci 60, A4, 2006
- MEG neuroimaging of delusions in epileptic psychosis
Ishii R, Ukai S, Iwase M, Shinosaki K, Takeda M
Psychiat and Clin Neurosci 60, A7, 2006
- The psychoneuroimmunological effect of laughter on patients with chronic fatigue syndrome
Iwase M, Takahashi K, Yamashita K, Tatsumoto Y, Ue H, Kuratsune H, Shimizu A, Takeda M
Psychiatry and Clinical Psychiat 60, A12, 2006
- The different patterns of cognitive impairment between autism spectrum disorders and schizophrenia
Iwase M, Takahashi H, Nakahachi T, Kajimoto O, Sekiyama R, Takahashi K, Ishii R, Ukai S, Shimizu A, Takeda M
Psychiat and Clin Neurosci 60, A18, 2006
- Spatial working memory relates to social function in schizophrenia
Takahashi H, Iwase M, Nakahachi T, Sekiyama R, Ishii R, Ukai S, Tabushi K, Kajimoto O, Shimizu A, Takeda M
Psychiat and Clin Neurosci 60, A48, 2006
- The effect of rTMS on neurogenesis in the dentate gyrus of rat hippocampus
Ueyama E, Ogawa A, Yamamoto M, Kawaguchi S, Masumoto N, Shouyama M, Kose A, Tsuji T, Kitabata Y, Ishii R, Ukai S, Kudo T, Shinosaki K
Psychiat and Clin Neurosci 60, A49, 2006
- Biological markers for diagnosis of MCI and neurodegenerative dementia
M. Takeda, T Kudo, T Tanaka, K Kamino, M Okochi, S Tagami
Functional and Moleculart Imaging of Strokeka dn Dementia (Nishimura T & Sorensen GA eds), 101-107, Elsevier, 2006
- Neural correlates of symptom improvement in posttraumatic stress disorder; Psitron emission tomography study.
Tokunaga H, Ikejiri Y, Kazui H, Masaki Y, Hatta N, Doronbekov T, Honda M, Oku N, Hatazawa J, Nishikawa N, Takeda M;
In; PTSD; Brain mechanisms and clinical implications. N Kato, R Kawata, K Pitman (Eds.),247-254, Springer-Verlag Tokyo, 2006
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