Recent Discoveries | Graduate School of Medicine / Faculty of Medicine, The University of Osaka

Activation of the integrin αV–YAP–CTGF axis in liver sinusoidal endothelial cells promotes liver fibrogenesis, leading to portal hypertension and liver carcinogenesis in congestive hepatopathy

Seiya Kato, Hayato Hikita and Tetsuo Takehara ≪Gastroenterology and Hepatology≫
Gastroenterology

Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling

Nanao Horike, Takahiro Nemoto, Masahito Ikawa, and Noriyuki Tsumaki ≪Tissue Biochemistry≫
Nature Communications

Reaching the unreachable: New technique opens route to deep lung tumors A balloon-assisted endoscopy technique enables safe, direct access to peripheral lung fields for early lung cancer diagnosis.

Kotaro Miyake, Atsushi Kumanogoh ≪Respiratory Medicine and Clinical Immunology≫
Thorax

Reducing reliance on corticosteroids with rituximab: renewed hope for adult-onset patients with relapsing nephrotic syndrome

Yoshitaka Isaka, Yusuke Sakaguchi, Maki Shinzawa ≪Nephrology≫
JAMA

Researchers unveil the immune cells responsible for systemic sclerosis’s deadliest complications

Hiroshi Shimagami, Masayuki Nishide ≪Respiratory Medicine and Clinical Immunology≫, Masashi Narazaki ≪Advanced Clinical and Translational Immunology≫
Nature Communications

Immune system warriors predict the future of autoimmune blood vessel disease

Masayuki Nishide ≪Respiratory Medicine and Clinical Immunology≫, Masashi Narazaki≪Advanced Clinical and Translational Immunology≫
Nature Communications

Driving the CAR to fight acute myeloid leukemia

Naoki Hosen ≪Hematology and Oncology≫
Nature Cancer

Selenoproteins: the fountain of youth?

Hiromi Yamazaki, Daichi Inoue ≪Cancer Pathology≫
Blood

Mechanism behind autophagy trigger unveiled

Maho Hamasaki ≪Genetics≫
Nature Communications

Shocking revelation: an electrically-activated protein regulates spermatogenesis

Takafumi Kawai, Yasushi Okamura ≪Integrative Physiology≫
Nature Communications