Achievements

2024

Original articles

  1. Kaneda Y, Miyata H, Xu Z, Shimada K, Kamoshita M, Nakagawa T, Emori C, Ikawa M. FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility. Elife. 2024 13:RP92794. doi: 10.7554/eLife.92794.
  2. Yamamoto K, Hiradate Y, Ikawa M. Eighteen genes primarily expressed in the testis are not required for male fertility in mice. Biol Reprod. 2024 119. doi: 10.1093/biolre/ioae119. Online ahead of print.
  3. Wang H, Kobayashi H, Shimada K, Oura S, Oyama Y, Kitakaze H, Noda T, Yabuta N, Miyata H, Ikawa M. MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice. J Cell Sci. 2024 137(16):jcs261962. doi: 10.1242/jcs.261962.
  4. Miyata H, Shimada K, Kaneda Y, Ikawa M. Development of functional spermatozoa in mammalian spermiogenesis. Development. 2024 151(14):dev202838. doi: 10.1242/dev.202838
  5. Wang H, Iida-Norita R, Mashiko D, Pham AH, Miyata H, Ikawa M. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. PLoS Genet. 2024 20(6):e1011337. doi: 10.1371/journal.pgen.1011337.
  6. Nguyen TTT, Tokuhiro K, Shimada K, Wang H, Mashiko D, Tonai S, Kiyozumi D, Ikawa M. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Front Cell Dev Biol. 2024 12:1411162. doi: 10.3389/fcell.2024.1411162.
  7. Pham AH, Emori C, Ishikawa-Yamauchi Y, Tokuhiro K, Kamoshita M, Fujihara Y, Ikawa M. Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Cells. 2024 13(10):802. doi: 10.3390/cells13100802.
  8. Suzuki A, Yabuta N, Shimada K, Mashiko D, Tokuhiro K, Oyama Y, Miyata H, Garcia TX, Matzuk MM, Ikawa M. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. J Reprod Immunol. 2024 163:104252. doi: 10.1016/j.jri.2024.104252.
  9. Noda T, Shinohara H, Kobayashi S, Taira A, Oura S, Tahara D, Tokuyasu M, Araki K, Ikawa M. Multiple genes in the Pate5-13 genomic region contribute to ADAM3 processing. Biol Reprod. 2024 110(4):750-760. doi: 10.1093/biolre/ioae008.
  10. Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, Okuzaki D, Shimada K, Miyata H, Shimada K, Kodani M, Ishikawa-Yamauchi Y, Motooka D, Hara E, Ikawa M. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice. Commun Biol. 2024 7(1):16. doi: 10.1038/s42003-023-05685-2.
  11. Kanatsu-Shinohara M, Morimoto H, Liu T, Tamura M, Shinohara T. Sendai virus-mediated RNA delivery restores fertility to congenital and chemotherapy-induced infertile female mice. PNAS Nexus. 2024 3(9):pgae375. doi: 10.1093/pnasnexus/pgae375.
  12. Kanatsu-Shinohara M, Yamamoto T, Morimoto H, Liu T, Shinohara T. Spermatogonial stem cells in the 129 inbred strain exhibit unique requirements for self-renewal. Development. 2024 151(12):dev202553. doi: 10.1242/dev.202553.
  13. Morimoto H, Ogonuki N, Matoba S, Kanatsu-Shinohara M, Ogura A, Shinohara T. Restoration of fertility in nonablated recipient mice after spermatogonial stem cell transplantation. Stem Cell Reports. 2024 19(4):443-455. doi: 10.1016/j.stemcr.2024.02.003.
  14. Shirasawa A, Hayashi M, Shono M, Ideta A, Yoshino T, Hayashi K. Efficient derivation of embryonic stem cells and primordial germ cell-like cells in cattle. J Reprod Dev. 2024 70(2):82-95. doi: 10.1262/jrd.2023-087.

Reviews/Protocols/Books

  1. Oikawa M, Hirabayashi M, Kobayashi T.　Induction of Primordial Germ Cell-Like Cells from Rat Pluripotent Stem Cells. Methods Mol Biol. 2024;2770:99-111. doi: 10.1007/978-1-0716-3698-5_8.

Oral presentations

  1. Katsuhiko Hayashi: Reconstitution of Germ Cell and Gonad Development using Pluripotent stem cells. ISSCR. July 10-13, 2024 Hamburg, Germany.
  2. Katsuhiko Hayashi: Reconstitution of germ cell lineage and gonadal environment using pluripotent stem cells. The Society for the Study of Reproduction. July 15-19, 2024 Dublin, Ireland.

Award

  1. Katsuhiko Hayashi: TIME100 - The Most Influential People of 2023