RESULTS

Block copolymer conjugate targets hepatocellular carcinoma stem cells (Oncogene, 2018)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki) and Tokyo Institute of Technology (Prof. Nobuhiro Nishiyama), Toshiyama et al. developed a block copolymer conjugate to increase the efficacy of reagents in cancer stem cells. The exposure increased the intracellular ROS concentration by inhibiting enzyme activity, permitting the induction of apoptosis and attenuation of cancer cell growth. This study demonstrated that it exerts a potent antitumor effect.