RESULTS

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis (Scientific Reports, 2018, in press)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Koseki et al. studied the significance of mitochondrial metabolism in cancer cells by computational approach as well as wet experiments, and demonstrated the importance of the one-carbon folate metabolism in metabolic cycle of tetrahydrofolate in mitochondria, SHMT2, MTHFD2, and ALDH1L2, suggesting the rationale of drug discovery in cancer medicine.