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HOME > Research progress / Achievements > Achievements : Programmed research project 07
Achievements

Programmed research project 07

Luminal epithelium integrity and the EMT
Outline
Research progress
Leader : Hisataka Sabe

Original Papers

  • Hashimoto, A., Oikawa, T., Hashimoto, S., Sugino, H., Yoshikawa, A., Otsuka, Y., Handa, H., Onodera, Y., Nam, J-M., Oneyama, C., Okada, M., Fukuda, M. and Sabe, H. p53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. J. Cell Biol., (in press).
  • Hashimoto, S., Mikami, S., Sugino, H., Yoshikawa, A., Hashimoto, A., Onodera, Y., Furukawa, S., Handa, H., Oikawa, T., Okada, Y. and Sabe, H. Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nat. Commun. 7: 10656, 2016.
  • Oneyama, C., Yoshikawa, Y., Ninomiya, Y., Iino, T., Tsukita, S. and Okada, M. Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression. Oncogene 35: 501-512, 2016.
  • Matsuyama, R., Okuzaki, D., Okada, M., Oneyama, C. MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling. Cancer Sci. 107: 28-35, 2016.
  • Oneyama, C., Okada, M. MicroRNAs as the fine-tuners of Src oncogenic signalling. J Biochem. 157: 431-438. 2015.
  • Kakumoto, K., Ikeda, J., Okada, M., Morii, E. and Oneyama, C. mLST8 promotes mTOR-mediated tumor progression. PLoS One, 10: e0119015, 2015.
  • Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M., Ashida, N. AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions. Sci Rep. 4: 5094, 2014.
  • Sato, H., Hatanaka, K.C., Hatanaka, Y., Hatakeyama, H., Hashimoto, A., Matsuno, Y., Fukuda, S., Sabe, H. High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients. Cell Commun Signal. 12: 17, 2014.
  • Saitou, T., Kajiwara, K., Oneyama, C., Suzuki, T., Okada, M. Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase. PLoS One. 9: e93470, 2014.
  • Mori, S., Nada, S., Kimura, H., Tajima, S., Takahashi, Y., Kitamura, A., Oneyama, C., Okada, M. The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase. PLoS One 9: e88891, 2014.
  • Kajiwara, K., Yamada, T., Bamba, T., Fukusaki, E., Imamoto, F., Okada, M., Oneyama, C. c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions. Biochem J. 458: 81-93, 2014.
  • Kinoshita R, Nam, J.M., Ito, Y.M., Hatanaka, K.C., Hashimoto, A., Handa, H., Otsuka, Y., Hashimoto, S., Onodera, Y., Hosoda, M., Onodera, S., Shimizu, S., Tanaka, S., Shirato, H., Tanino, M. and Sabe, H. Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy. PLoS One 8: e76791, 2013.
  • Nam, J.M., Ahmed, K.M., Costes, S., Zhang, H., Onodera, Y., Olshen, A.B., Hatanaka, K.C., Kinoshita, R., Ishikawa, M., Sabe, H., Shirato, H. and Park, C.C. : Beta1-integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer. Breast Cancer Res. 15: R60, 2013.[Epub ahead of print]
  • Oneyama, C., Kito, Y., Asai, R., Ikeda, J., Yoshida, T., Okuzaki, D., Kokuda, R., Kakumoto, K., Takayama, K., Inoue, S., Morii, E., Okada, M. MiR-424/503-mediated Rictor upregulation promotes tumor progression. PLoS One 8: e80300, 2013.
  • Soma-Nagae, T., Nada, S., Kitagawa, M., Takahashi, Y., Mori, S., Oneyama, C., Okada, M. The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes. J Cell Sci. 126: 3575-3584, 2013.
  • Tanaka, H., Akagi, K., Oneyama, C., Tanaka, M., Sasaki, Y., Kanou, T., Lee YH., Yokogawa, D., Dobenecker, MW., Nakagawa, A., Okada, M., Ikegami, T. Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. J Biol Chem. 288: 15240-15254, 2013.
  • Sekino-Suzuki, N., Yuyama, K., Miki, T., Kaneda, M., Suzuki, H., Yamamoto, N., Yamamoto, T., Oneyama, C., Okada, M., Kasahara, K. Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones. J Neurochem. 124: 514-522, 2013.
  • Miura, K., Wakayama, Y., Tanino, M., Orba, Y., Sawa, H., Hatakeyama, M., Tanaka, S., Sabe, H. and Mochizuki, N. Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. Oncogene. 32: 5292-5301, 2013.
  • Takahashi, Y., Nada, S., Mori, S., Soma-Nagae, T., Oneyama, C., Okada, M. The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes. Biochem Biophys Res Commun. 417: 1151-1157, 2012.
  • Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., Minami, Y. Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. J Biol Chem. 287: 1588-1599, 2012.
  • Onodera, Y., Nam, J.M., Hashimoto, A., Norman, J.C., Shirato, H., Hashimoto, S. and Sabe, H. Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. J. Cell Biol. 197: 983-996, 2012.
  • Mazaki, Y., Nishimura, Y. and Sabe, H. GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kg activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol. Biol. Cell 23: 2457-2467, 2012.
  • Oneyama C., Morii E., Okuzaki D., Takahashi Y., Ikeda J., Wakabayashi N., Akamatsu H., Tsujimoto M., Nishida T., Aozasa K. and Okada M. MicroRNA-mediated upregulation of integrin-linked kinase is crucial for Src-induced tumor progression. Oncogene 31: 1623-1635, 2012.
  • Li, J., Malaby, A.W., Famulok, M., Sabe, H., Lambright, D.G. and Hsu, V.W. Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev. Cell 22: 1286-1298, 2012.
  • Wakayama Y., Miura K., Sabe H. and Mochizuki N. EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating ezrin through negative regulation of RhoA. J. Biol. Chem. 286: 44243-44253, 2011.
  • Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H. Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma. PLoS One 6: e25301, 2011.
  • Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H. GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS One 6: e23359, 2011.
  • Oneyama C., Ikeda J., Okuzaki D., Suzuki K., Kanou T., Shintani Y., Morii E., Okumura M., Aozasa K. and Okada M. : MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways. Oncogene 30: 3489-3501, 2011.
  • Kuroiwa M., Oneyama C., Nada S. and Okada M. : A guanine nucleotide exchange factor Arhgef5 plays crucial roles in c-Src-induced podosome formation. J. Cell Sci. 124: 1726-1738, 2011.

Review Papers

  • Hashimoto, S., Hashimoto, A., Sugino, H., Yoshikawa, A., Handa, H., Yoshino, M., Otsuka, Y. and Sabe, H. ArfGAPs: not only for the termination. In "Ras-superfamily small G-proteins: biology and mechanisms" Vol. 2 pp253-274, (Ed. F. Wittenghofer, Springer Pub.) 2014.
  • Onodera, Y., Nam, J.M. and Sabe, H. Intracellular trafficking of integrins in cancer cells. Pharmacol Ther. 140: 1-9, 2013.
  • Sabe H., Onodera Y., Hashimoto A. and Hashimoto S. ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). Atlas Genet Cytogenet Oncol Haematol. February 2012. URL : http://AtlasGeneticsOncology.org/Genes/ASAP1ID44351ch8q24.html
  • Sabe H. Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling. J. Biochem. 149: 633-639, 2011.
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