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HOME > Research progress / Achievements > Achievements > 2012-2013: Proposed research project 03
Achievements

2012-2013: Proposed research project 03

Regulatory mechanism of formation and maintenance of epithelial polarity in normal colonic epithelial cells cultured in vitro
Outline
Research progress
Leader : Tetsuya Nakamura

Original Papers

  • Suzuki, M., Nagaishi, T., Yamazaki, M., Onizawa, T., Watabe, T., Sakamaki, Y., Ichinose, S., Totsuka, M., Oshima, S., Okamoto, R., Shimonaka, M., Yagita, H., Nakamura, T., Watanabe, M. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS One, (in press).
  • Murano, T., Okamoto, R., Ito, G., Nakata, T., Hibiya, S., Shimizu, H., Fujii, S., Kano, Y., Mizutani, T., Yui, S., Akiyama-Morio, J., Nemoto, Y., Tsuchiya, K., Nakamura, T., Watanabe, M. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 443(3): 840-846, 2013.
  • Fordham, RP., Yui, S., Hannan, NRF., Søndergaard, C., Madgwick, A., Schweiger, PJ., Nielsen, OH., Vallier, L., Pedersen, RA., Nakamura, T., Watanabe, M., Jensen, KB. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 13(6): 734-744, 2013.
  • Ito, G., Okamoto, R., Murano, T., Shimizu, H., Fujii, S., Nakata, T., Mizutani, T., Yui, S., Akiyama-Morio, J., Nemoto, Y., Okada, E., Araki, A., Ohtsuka, K., Tsuchiya, K., Nakamura, T., Watanabe, M. Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells. PLoS One 8(11): e79693, 2013.
  • Kano, Y., Tsuchiya, K., Zheng, X., Horita, N., Fukushima, K., Hibiya, S., Yamauchi, Y., Nishimura, T., Hinohara, K., Gotoh, N., Suzuki, S., Okamoto, R., Nakamura, T., Watanabe, M. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun. 432(1): 175-181, 2013.
  • Nemoto, Y., Kanai, T., Takahara, M., Oshima, S., Nakamura, T., Okamoto, R., Tsuchiya, K., Watanabe, M. Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut 62(8): 1142-1152, 2013.
  • Yui, S*., Nakamura, T*., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H., Watanabe, M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat. Med. 18(4): 618-623, 2012.
  • Yamaji, O., Nagaishi, T., Totsuka, T., Onizawa, M., Suzuki, M., Tsuge, N., Hasegawa, A., Okamoto, R., Tsuchiya, K., Nakamura, T., Arase, H., Kanai, T., Watanabe, M. The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J. Immunol. 188(6): 2524-2536, 2012.
  • Mizutani, T*., Nakamura, T*., §., Morikawa, R., Fukuda, M., Mochizuki, W., Yamauchi, Y., Nozaki, K., Yui, S., Nemoto, Y., Nagaishi, T., Okamoto, R., Tsuchiya, K., Watanabe, M. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun. 419(2): 238-243, 2012.
2012-2013: Project 02 Index of Projects 2012-2013: Project 04
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