Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2012-2013: Proposed research project 23

Molecular mechanism for aberrant tubular formation during intestinal carcinogenesis

Leader :

Toshiro Sato

Huch, M., Dorrell, C., Boj, SF., van Es, JH., Li, VSW., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, MJ., Haft, A., Vries, R., Grompe, M., Clevers, H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature, 2013 (in press).
van Es, JH.^#, Sato, T.^#, van de Wetering, M., Lyubimova, A., Yee Nee, AN., Gregorieff, A., Sasaki, N., Zeinstra, L., van den Born, M., Korving, J., Martens, AC., Barker, N., van Oudenaarden, A., Clevers, H. Dll1(+) secretory progenitor cells revert to stem cells upon crypt damage. Nat. Cell Biol. 14: 1099-1104, 2012. ^#Equal authorship
Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H., Watanabe, M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nature Medicine 18: 618-623. 2012.
Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H., Galle, J. On the biomechanics of stem cell niche formation in the gut - modelling growing organoids. FEBS J. 279: 3475-3487, 2012.
Stringer, EJ., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, CA., Winton, DJ., Wright, NA., Freund, JN., Deschamps, J., Beck, F. Cdx2 determines the fate of postnatal intestinal endoderm. Development 139: 465-474, 2012.

Sato, T., Clevers, H., Primary culture for small intestinal stem cells. Methods in Molecular Biology. 945: 319-328, 2013.
Sato, T. Intestinal Stem Cell Culture. Inflammation and Regeneration. 32: 43-47 2012.