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HOME > Research progress / Achievements > Achievements > 2014-2015: Proposed research project 01
Achievements

2014-2015: Proposed research project 01

In Vitro 3D Cultures for Studies on Structural Formation and Regeneration of Intestinal Epithelium
Outline
Research progress
Leader : Tetsuya Nakamura

Original Papers

  • Nozaki, K., Mochizuki, W., Matsumoto, Y., Matsumoto, T., Fukuda, M., Mizutani, T., Watanabe, M., Nakamura, T. Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. DOI: 10.1007/s00535-016-1170-8 2016.
  • Fukuda, M., Mizutani, T., Mochizuki, W., Matsumoto, T., Nozaki, K., Sakamaki, Y., Ichinose, S., Okada, Y., Tanaka, T., Watanabe, M., Nakamura, T. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 28: 1752-1757, 2014.
  • Suzuki, M., Nagaishi, T., Yamazaki, M., Onizawa, T., Watabe, T., Sakamaki, Y., Ichinose, S., Totsuka, M., Oshima, S., Okamoto, R., Shimonaka, M., Yagita, H., Nakamura, T., Watanabe, M. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE 9: e88369, 2014.
  • Fordham, R.P., Yui, S., Hannan, N.R.F., Søndergaard, C., Madgwick, A., Schweiger, P.J., Nielsen, O.H., Vallier, L., Pedersen, R.A., Nakamura, T., Watanabe, M., Jensen, K.B. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 13(6): 734-744, 2013.
  • Ito, G., Okamoto, R., Murano, T., Shimizu, H., Fujii, S., Nakata, T., Mizutani, T., Yui, S., Akiyama-Morio, J., Nemoto, Y., Okada, E., Araki, A., Ohtsuka, K., Tsuchiya, K., Nakamura, T., Watanabe, M. Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells. PLoS ONE 8: e79693, 2013.
  • Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H., Watanabe, M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat. Med. 18: 618-623, 2012.

Review Papers

  • Nakamura, T. Epithelial regeneration by transplantation of cultured intestinal stem cells. Inflammation and Regeneration 35(1): 19-22, 2015.
  Index of Projects 2014-2015: Project 02
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