Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2014-2015: Proposed research project 04

Roles of actin-dependent intracellular force in cell-cell communication in epithelial cells

Leader :

Sawako Yamashiro

Ono, K., Obinata, T., Yamashiro, S., Liu, Z., Ono, S. UNC-87 isoforms, C. elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility. Mol. Biol. Cell 26: 1687-1698, 2015.
Yamashiro, S., Gokhin, D.S., Sui, Z., Bergeron, S.E., Rubenstein, P.A., Fowler, V.M. Differential actin-regulatory activities of tropomodulin1 and tropomodulin3 with diverse tropomyosin and actin isoforms. J. Biol. Chem. 289: 11616-11629, 2014.
Lewis, R.A., Yamashiro, S., Gokhin, D.S., Fowler, V.M. Functional effects of mutations in the tropomyosin-binding sites of tropomodulin1 and tropomodulin3. Cytoskeleton 71:395-411, 2014.
Yamashiro, S., Mizuno, H., Smith, M.B., Ryan, G.L., Kiuchi, T., Vavylonis, D., Watanabe, N. A new single-molecule speckle microscopy reveals modification of the retrograde actin flow by focal adhesions at nanometer scales. Mol. Biol. Cell 25:1010-1024, 2014.

Yamashiro, S., Watanabe, N. An easy-to-use single-molecule speckle microscopy enabling nanometer-scale flow and wide-range lifetime measurement of cellular actin filaments. Methods Cell Biol. 125:43-59, 2015.
Yamashiro, S., Watanabe, N. A new link between the retrograde actin flow and focal adhesions. J. Biochem. 156:239-248, 2014.