Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2014-2015: Proposed research project 08

Regulatory mechanisms of cellular dynamics in epithelial tissues

Leader :

Hiroshi Sasaki

Mamada, H., Sato, T., Ota, M., Sasaki, H. Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J. Cell Sci. 128: 790-803, 2015.
Wicklow, E., Blij, S., Frum, R., Hirate, Y., Lang, R.A., Sasaki, H., Ralston, A. HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 10: e1004618, 2014.
Rayon, T., Menchero, S., Nieto, A., Xenopoulos, P., Crespo, M., Cockburn, K., Cañon, S., Sasaki, H., Hadjantonakis, A.K., de la Pompa, J.L., Rossant, J., Manzanares, M. Notch and hippo converge on cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev. Cell 30: 410-422, 2014.
Imuta, Y., Koyama, H., Shi, D., Eiraku, M., Fujimori, T., Sasaki, H. Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos. Mech. Dev. 132: 44-58, 2014.

Sasaki, H. Position- and polarity-dependent Hippo signaling regulates cell fates in preimplantation mouse embryos. Semin. Cell Dev. Biol. (invited review) 47-48: 80-87, 2015.
Hirate, Y., Sasaki, H. The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers (invited review), 2: e28127, 2014.