Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2014-2015: Proposed research project 10

A mechano-chemical coupling mechanism underlying optic cup morphogenesis in embryonic stem cell-derived tissue culture

Leader :

Mototsugu Eiraku

Sakaguchi, H., Kadoshima, T., Soen, M., Narii, N., Ishida, Y., Ohgushi, M., Takahashi, J., Eiraku, M., Sasai, Y. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat. Commun. 6: 8896, 2015.
Okuda, S., Inoue, Y., Eiraku, M., Adachi, T., Sasai, Y. Modeling cell apoptosis for simulating three0dimensional multicellular morphogenesis based on a reversible network reconnection framework. Biomech Model Mechanobiol. Sep 11, 2015 (on line).
Kuwahara, A., Ozone, C., Nakano, T., Saito, K., Eiraku, M., Sasai, Y. Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nat. Commun. 6: 6286, 2015.
Okuda, S., Inoue, Y., Eiraku, M., Adachi, T., Sasai, Y. Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis. Biomech. Model. Mechanobiol. 14: 413-425, 2014.
Assawachananont, J., Mandai, M., Okamoto, S., Yamada, C., Eiraku, M., Yonemura, S., Sasai, Y., Takahashi, M. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports 2: 662-674, 2014.