Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2014-2015: Proposed research project 13

Intravital multi-dimensional imaging analysis on the liver epithelial tissue dynamics in regeneration and homeostasis

Leader :

Tohru Itoh

Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S. O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-Ya, K., Mimori, K., Suzuki, A. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc. Natl. Acad. Sci. USA 113: E71-E80, 2016.
Kaneko, K., Kamimoto, K., Miyajima, A., Itoh, T. Adaptive remodeling of the biliary architecture underlies liver homeostasis. Hepatology 61: 2056-2066, 2015.
Taguchi, K., Hirano, I., Itoh, T., Tanaka, M., Miyajima, A., Suzuki, A., Motohashi, H., Yamamoto, M. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. Mol. Cell. Biol. 34: 900-913, 2014.
Takase, H. M., Itoh, T., Ino, S., Wang, T., Koji, T., Akira, S., Takikawa, Y., Miyajima, A. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 27: 169-181, 2013.

Itoh, T., Kok, C. Y., Takase, H., Miyajima, A. Liver stem cells (Chapter 8). Regenerative Medicine: From Protocol to Patient, 3rd edition, edited by Steinhoff, G., Springer, (in press).
Itoh, T. (2015). Liver stem cell niche (Chapter 5). Tissue-Specific Stem Cell Niche, edited by Turksen, K., Springer. 83-97, 2015.
Kok, C. Y., Miyajima, A., Itoh, T. Adaptive remodelling of the biliary tree: the essence of liver progenitor cell expansion. J. Hepatobiliary Pancreat. Sci. 22: 546-550, 2015.
Miyajima, A., Tanaka, M., Itoh, T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell 14: 561-574, 2014.
Itoh, T., Miyajima, A. Liver regeneration by stem/progenitor cells. Hepatology 59: 1617-1626, 2014.
Itoh, T., Takase, H., Tanaka, M., Miyajima, A. Liver stem cells (Chapter 13). Regenerative Medicine: From Protocol to Patient, 2nd edition, edited by Steinhoff, G., Springer. 337-363, 2013.