Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2014-2015: Proposed research project 15

Cytoskeletal regulation of kidney tubulogenesis in mice and humans

Leader :

Ryuichi Nishinakamura

Recuenco, M.C., Ohmori, T., Tanigawa, S., Taguchi, A., Fujimura, S., Conti, M.A., Wei, Q., Kiyonari, H., Abe, T., Adelstein, R.S., Nishinakamura, R. Non-muscle myosin II regulates the morphogenesis of metanephric mesenchyme-derived immature nephrons. J. Am. Soc. Nephrol. 26: 1081-1091, 2015.
Nishita, M., Qiao, S., Miyamoto, M., Okinaka, Y., M., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., Minami, Y. Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol. Cell. Biol. 34: 3096-3105, 2014.
Kanda, S., Tanigawa, S., Ohmori, T., Taguchi, A., Kudo, K., Suzuki, Y., Sato, Y., Hino, S., Sander, M., Perantoni, A.O., Sugano, S., Nakao, M., Nishinakamura, R. Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor. J. Am. Soc. Nephrol. 25: 2584-2595, 2014.

Taguchi, A., Nishinakamura, R. 3D nephron reconstitution from pluripotent stem cells: lessons from developmental processes in vivo. Kidney Int. 87: 894-900. 2015.