News and
Topics
News and
Topics
August 28, 1997---Retrovirus and Autoimmunity !! (Click here for related issue)
A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. B. Conrad, R. N. Weissmahr, J. Boni, R. Arcari, J. Schupbach and B. Mach. Cell 90, 303-313, 1997 (Abstract)
Retrovirus as trigger, precipitator or marker ? C. Benoist and D. Mathis. Nature 388, 833-834, 1997.
June28, 1997---Myeloma-Kaposi's Sarcoma-Associated Herpesvirus-Interleukin-6 !!(Click here for more information)
Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients. M. B. Rettig, * H. J. Ma, R. A. Vescio, M. Pold, G. Schiller, D. Belson, A. Savage, C. Nishikubo, C. Wu, J. Fraser, J. W. Said, J. R. Berenson. Science 276, 1851-1854, 1997(Abstract)
Causing Cancer by Remote Control?, Science 20 June 1997; 276 (5320):1788 (in Research News), T. Gura
Moore PS, Boshoff C, Weiss RA, Chang Y, Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274 (5293): 1739-1744, 1996 (PubMed)
Kaisho, T., K. Oritani, J. Ishikawa, M. Tanabe, O. Muraoka, T. Ochi, and T. Hirano. Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis which can support murine preB cell growth. J. Immunol. 149: 4088-4095, 1992.(PubMed)
Hirano, T. Interleukin 6 (IL-6) and its receptor: Their role in plasma cell neoplasias. International Journal of Cell Cloning 9: 166-184, 1991.(PubMed)
Hirano, T. Interleukin-6 and its relation to inflammation and disease. Clinical Immunology and Immunopathology. 62, S60-S65, 1992. -----proposing a model showing the possible involvement of virus, which is capable of inducing a variety of genes including the IL-6 gene, in the development of plasmacytoma/myeloma and rheumatoid arthritis (PubMed).(Clik here for related issue.)
February 3, 1997---T Helper 2 (Th2) and interleukin-6 !!
Rincon, M., J. anguita, T. Nakamura, E. Fikring and R. A. Flavell. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185, 461-469, 1997.
Coffman, R. L., and T. von der Weid. Multiple pathways for the initiation of T helper 2 (Th2) responses. J. Exp. Med. 185, 373-375, 1997.
Zheng, W., and R. A. Flavell. The transcriptional factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596, 1997.
February 2, 1997---A bioactive designer cytokine---IL-6-sIL-6R complex
Fisher, M., J. Goldschmitt, C. Peschel, J. P. G. Brakenhoff, K.-J. Kallen, a. Wollmer, J. Grotzinger and S. Rose-John. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nature Biotechnology 15, 142-145, 1997.
Hirano, T., T. Matsuda, and K. Nakajima. Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells, 12: 262-277, 1994.(MedLine ) ( click here for detail explanation for the below figure )
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