ii)
Transcriptional activation of the IL-6 response element in the junB
promoter is mediated by multiple Stat family proteins. Fujitani-Y;
Nakajima-K; Kojima-H; Nakae-K; Takeda-T; Hirano-T,
Biochem-Biophys-Res-Commun. 1994 Jul 29; 202(2): 1181-7ii)
Transcriptional activation of the IL-6 response element in the junB
promoter is mediated by multiple Stat family proteins. Fujitani-Y;
Nakajima-K; Kojima-H; Nakae-K; Takeda-T; Hirano-T,
Biochem-Biophys-Res-Commun. 1994 Jul 29; 202(2): 1181-7
IL-6 signals activate an IL-6 response element in the junB promoter,
JRE-IL6, in a Ras-independent manner. IL-6 rapidly induced a
DNA-binding activity to the Ets binding site of JRE-IL6 (JEBS), one
of necessary DNA motifs of the IL-6 response element. The
IL-6-induced JEBS-binding activity was indistinguishable from those
to acute phase response element (APRE) in both kinetics of induction
and its DNA-binding specificity. Purified APRE binding factors
(APRFs) from IL-6-stimulated rat liver were found to be composed of
multiple Stat3-related proteins and Stat1. Moreover the purified
APRFs specifically made a complex with JRE-IL6 with the same mobility
as that observed in the crude extracts. These results indicate that
an immediate early signal of IL-6 leading to activation of JRE-IL6 is
mediated by STAT family transcription factors.
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