iii) ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1.
Hirata-Y; Kimura-N; Sato-K; Ohsugi-Y; Takasawa-S; Okamoto-H; Ishikawa-J; Kaisho-T; Ishihara-K; Hirano-T, FEBS-Lett. 1994 Dec 19; 356(2-3): 244-8

Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST-1 might possess ADP ribosyl cyclase activity. Here, we report the establishment of a stable transformant CHO cell line, which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase and cADPR hydrolase activities.

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