v) BST-1, a
surface molecule of bone marrow stromal cell lines that facilitates
pre-B-cell growth.Kaisho-T; Ishikawa-J; Oritani-K; Inazawa-J; Tomizawa-H; Muraoka-O; Ochi-T; Hirano-T, Proc-Natl-Acad-Sci-U-S-A. 1994 Jun 7; 91(12): 5325-9
v) BST-1, a
surface molecule of bone marrow stromal cell lines that facilitates
pre-B-cell growth.
Bone marrow stromal cells are essential for B-lymphocyte development.
However, how stromal cells regulate B lymphopoiesis is not clear. In
this paper, we report the molecular cloning of a stromal cell
line-derived glycosyl-phosphatidylinositol-anchored molecule, BST-1,
that facilitates pre-B-cell growth. The deduced amino acid sequence
of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a
wide range of tissues and in umbilical vein endothelial cells,
whereas it was scarcely expressed in a variety of hematopoietic cell
lines. The gene for BST-1 was assigned to chromosome 14q32.3, where
immunoglobulin heavy-chain genes are clustered. BST-1 expression was
enhanced in rheumatoid arthritis patient-derived bone marrow stromal
cell lines that were previously shown to have an enhanced ability to
support the growth of a pre-B-cell line as compared with stromal cell
lines derived from healthy donors.
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