伊藤素行

Motoyuki Itoh

Unit on Molecular Signal System, Division of Biological Science,

Graduate School of Science, Nagoya University

Furou-cho, Chikusa-ku, Nagoya 464-8602, Japan

Tel +81-52-789-2599 or +81-52-788-6034

FAX +81-52-789-2589 or +81-52-788-6035

Ph.D received 3/1998

1987-1991 Osaka University Japan Pharmaceutical science Bachelor

1991-1993 Osaka University Japan Pharmaceutical science Master

1994-1998 Osaka University Japan Medical science Ph.D

1998-1999 Osaka University Japan Postdoctral fellow

1999-2003 LMG/NICHD USA Postdoctral fellow

July, 2003- Nagoya University Japan Assistant professor

Awards

Japan Scholarship Association

Japan Society for the Promotion of Science for young scientists

JSPS Research Fellowships for Japanese Biomedical and Behavioral Researchers at NIH

23) Itoh, M, Kim C-H, Palardy G, Oda T, Jiang Y-J, Maust D, Yeo S-Y, Lorick K, Wright G.J., Ariza-McNaughton L, Weissman A.M., Lewis J, Chandrasekharappa S.C. and Chitnis A.B. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell., 2003, 4:67-82

22) Dorsky, R. I.*, Itoh,M*, Moon R.T., and Chitnis AB. Two tcf3 genes cooperate to pattern the zebrafish brain by setting the baseline of a Wnt activity gradient in the neurectoderm (* equally contributed). Develompment, 2003. 130:1937-47,

21) Geling A*, Itoh M*, Tallafuｧ A, Chapouton P, Tannh隔ser B, Kuwada J.Y., Chitnis A.B. and Bally-Cuif L. Regional inhibition of neurogenesis by the zebrafish bHLH transcription factor Her5 shapes the midbrain-hindbrain neuronal differentiation pattern. (* equally contributed), Develompment, 2003. 130:1591-604,

20)Yamasaki S, Nishida K, Yoshida Y, Itoh M, Hibi M, Hirano T.　Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.

Oncogene. 2003. 22:1546-56.

19) Itoh M, Kudoh T, Dedekian M, Kim CH, Chitnis A.B. A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development. 2002. 129:2317-27

18) Itoh, S., M. Itoh, K. Nishida, S. Yamasaki, Y. Yoshida, M. Narimatsu, S. J. Park, M. Hibi, K. Ishihara, and T. Hirano. Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses. J. Immunol. 2002 168:5110-5116.

17) Narimatsu, M., H. Maeda, S. Itoh, T. Atsumi, T. Ohtani, K. Nishida, M. Itoh, D. Kamimura, S.-J. Park, K. Mizuno, J. Miyazaki, M. Hibi, K. Ishihara, K. Nakajima and T. Hirano. Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells. Mol. Cell. Biol. 2001, 21:6615-6625.

16) Itoh M, Chitnis AB. Expression of proneural and neurogenic genes in the zebrafish lateral line primordium correlates with selection of hair cell fate in neuromasts.

Mech Dev. 2001. 102:263-6.

15) Kim C-H, Oda T, Itoh M, Jiang D, Artinger KB, Chandrasekharappa SC, Driever W, Chitnis A.B.. Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature., 2000. 407:913-6.

14) Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M., and Hirano, T. A role of Gab1 for heart, placenta, and skin development, and growth factors- and cytokines-induced ERK MAP kinase activation. Mol. Cell. Biol. 20, 3695-3704, 2000.(PubMed)(Abstract)(Full Text in MCB)

13) Ohtani, T., K. Ishihara, T. Atsumi, K. Nishida, Y. Kaneko, T. Miyata�, S. Itoh, M. Narimatsu, H. Maeda, T. Fukada､, M. Itoh, H. Okano, M. Hibi and T. Hirano. Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity, 12, 95-105, 2000. (PubMed) (Full Text in Immunity)

12) Hashimoto, H., M. Itoh, Y. Yamanaka, S. Yamashita, T. Shimizu, L. Solnica-Krezel, M. Hibi, and T. Hirano. Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation. Developmental Biology 217, 138-152, 2000.(Abstract)(PubMed)

11) Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. Gab-family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Blood, 93:1809-1816, 1999.(PubMed)

10) Itoh, M., K. Ishihara, T. Hiroi, B. Ok Lee, H. Maeda, H. Iijima, M. Yanagita, H. Kiyono, and T. Hirano. Deletion of BST-1(CD157) gene impaired systemic TI-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses.
J. Immunol. 161: 3974-3983, 1998. (Abstract) (J. Immunol)(PubMed)(Full Text in JI)

9) Ishihara, K., Okuyama, Y., Lee, B.OK, Itoh, M., Nishikawa, K., and Hirano, T. Structure, expression, and function of BST-1: its identity with Mo5., in Leucocyte typing VI, 1086-1089, 1997 (FullText)

8) Muraoka, O., H. Tanaka, M. Itoh, K. Ishihara and T. Hirano. Genomic structure of human BST-1. Immunology Letters, 54:1-4, 1996.

7) Okuyama, Y., K. Ishihara, N. Kimura, Y. Hirata, K. Sato, M. Itho, B. O. Lee, and T. Hirano. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem. Biophys. Res. Comm. 228:838-845, 1996. PubMed

6) Ishihara, K., Y. Kobune, Y. Okuyama, M. Itoh, B.O. Lee, O. Muraoka, and T. Hirano. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int. Immunol. 8: 1395-1404, 1996. (Abstract)

5) Kajimoto, Y., J.-I. Miyagawa, K. Ishihara, Y. Okuyama, Y. Fujitani, M. Itoh, H. Yoshida, T. Kaisho, T. Matsuoka, H. Watada, T. Hanafusa, Y. Yamasaki, T. Kameda, Y. Matsuzawa, and T. Hirano. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem. Biophys. Res. Comm. 219: 941-946, 1996.

4) Lee, B. O., K. Ishihara, K. Denno, Y. Kobune, M. Itoh, O. Muraoka, T. Kaisho, T. Sasaki, T. Ochi, and T. Hirano. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 39: 629-637, 1996. (Abstract)

3) Ishikawa, J., T. Kaisho, H. Tomizawa, B.O. Lee, Y. Kobune, J. Inazawa, K. Oritani, M. Itoh, T. Ochi, K. Ishihara, and T. Hirano. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics, 26: 527-534, 1995.

2) Itoh, M., K. Ishihara, H. Tomizawa, H. Tanaka, Y. Kobune, J. Ishikawa,. T. Kaisho and T. Hirano. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem. Biophys. Res. Comm., 203: 1309-1317, 1994. (Abstract)

1) Doi, T., T. Minami, M. Itoh, H. Aburatani, Y. Kawabe, T. Kodama, N. Kondo, Y. Satoh, T. Asayama, and T. Imanishi. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. Biochem Biophys Res Commun. 1997. 235:625-30.