大阪大学高等共創研究院 栁澤研究室のWEBサイトです。脳波や脳磁図などの脳信号に人工知能の技術を適用することで新しい診断・治療法を開発しています。情報や工学、神経科学など様々な分野の研究者と共同で新しい技術を開発し、これを臨床応用することで、新しい医療を作ることを目指しています。Yanagisawa Laboratory, School of Advanced Co-creative Studies, Osaka University. We develops new diagnostic and therapeutic methods by applying artificial intelligence technology to brain signals such as EEG and magnetoencephalography. We aim to create new medical treatment by developing new technologies in collaboration with researchers in various fields such as information, engineering and neuroscience, and applying them clinically.
研究業績
主な英語論文
Izutsu N,Yanagisawa Y, Fukuma R,Kishima H,Magnetoencephalographic neurofeedback training decreases β-low-γ phase-amplitude coupling of the motor cortex of healthy adults: a double- blinded randomized crossover feasibility study,Journal of Neural Engneering,20:3,doi:10.1088/ 1741-2552/acd0d6 | https://iopscience.iop.org/article/10.1088/1741-2552/acd0d6|2023/5/9
Fukuma R, Yanagisawa T, Nishimoto S, Sugano H & Tamura K, Voluntary control 1 of semantic neural representations by imagery with conflicting visual stimulation, Communications biology, (2022) 5:214 | https://doi.org/10.1038/s42003-022-03137-x | www.nature.com/commsbio. 我々の研究が日刊工業新聞2022/6/29版のトップニュースとして掲載されました。 日刊工業新聞 電子版 (nikkan.co.jp)
Yamamoto S, Yanagisawa T, Fukuma R, Oshino S, Tani N, Khoo HM, Edakawa K, Kobayashi M, Tanaka M, Fujita Y, Kishima H. Data-driven electrophysiological feature based on deep learning to detect epileptic seizures, Journal of Neural Engineering, 2021 Sep 3. doi: 10.1088/1741-2552/ac23bf. Online ahead of print
Hashimoto H, Takahashi K, Kameda S, Yoshida F, Maezawa H, Oshino S, Tani N, Khoo HM, Yanagisawa T, Yoshimine T, Kishima H, Hirata M, Motor and sensory cortical processing of neural oscillatory activities revealed by human swallowing using intracranial electrodes. 2021 Jun 25; 24(7):102786. Doi: 10.1016/j.isci.2021.102786.
Hashimoto H, Takahashi K, Kameda S, Yoshida F, Maezawa H, Oshino S, Tani N, Khoo HM, Yanagisawa T, Yoshimine T, Kishima H, Hirata M., Swallowing-related neural oscillation: an intracranial EEG study., Ann Clin Transl Neurol. 2021 Jun;8(6):1224-1238. doi: 10.1002/acn3.51344. Epub 2021 May 5.
Hashimoto H, Khoo HM, Yanagisawa T, Tani N, Oshino S, Kishima H, Hirata M., Phase-amplitude coupling of ripple activities during seizure evolution with theta phase. Clin Neurophysiol. 2021 Jun;132(6):1243-1253. doi: 10.1016/j.clinph.2021.03.007. Epub 2021 Mar 26.
Hashimoto H, Kameda S, Maezawa H, Oshino S, Tani N, Khoo HM, Yanagisawa T, Yoshimine T, Kishima H, Hirata M., A swallowing decoder based on deep transfer learning: AlexNet classification of the intracranial electrocorticogram., Int J Neural Syst. 2020 Sep 16:2050056. doi: 10.1142/S0129065720500562. Online ahead of print.
Hashimoto H, Khoo HM, Yanagisawa T, Tani N, Oshino S, Kishima H, Hirata M., Coupling between infraslow activities and high-frequency oscillations precedes sizure onset., Epilepsia Open., 2020 Aug 8;5(3): 501-506. doi: 10.1002/epi4.12425. eCollection 2020 Sep.
Zhang S, Yoshida W, Mano H,Yanagisawa T, Mancini F, Shibata K, Kawato M, Seymour B., Pain Control by Co-adaptive Learning in a Brain-Machine Interface., Current Biology. 2020 Aug 6:S0960-9822(20)31091-5. doi: 10.1016/j.cub.2020.07.066. Online ahead of print. PMID: 32795441
Yanagisawa T, Fukuma R, B Seymouret al. BCI training to move a virtual hand reduces phantom limb pain: A randomized crossover trial, NEUROLOGY, Published Ahead of Print on July 16, 2020 as 10.1212/WNL.0000000000009858
Yoshiyuki Shiraishi, Yoshinobu Kawahara, Okito Yamashita, Ryohei Fukuma, Shota Yamamoto, Youichi Saitoh, Haruhiko Kishima and Takufumi Yanagisawa, Neural decoding of electrocorticographic signals using dynamic mode decomposition,Journal of Neural Engineering ,Accepted Manuscript online 14 April 2020,https://doi.org/10.1088/1741-2552/ab8910, media
Fukuma, R., Yanagisawa, T., Kinoshita, M. et al. Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network. Sci Rep 9, 20311 (2019) doi:10.1038/s41598-019-56767-3, Published 30 Dec 2019 media
John SE, Grayden DB, Yanagisawa T., The future potential of the Stentrode., Expert Rev med Devices, 2019 Sep 30, 1745-2422, doi: 10.1080/17434440.2019.1674139. [Epub ahead of print] media
St. Clair Kirin, Takufumi Yanagisawa*, Satoru Oshino, Kohtaroh Edakawa, Masataka Tanaka, Haruhiko Kishima, Yukio Nishimura*, Somatosensation Evoked by Cortical Surface Stimulation of the Human Primary Somatosensory Cortex, frontiers in Neuroscience, 24 Sep 2019media
Jo Aoe, Ryohei Fukuma, Takufumi Yanagisawa, Tatsuya Harada, Masataka Tanaka, Maki Kobayashi, You Inoue, Shota Yamamoto, Yuichiro Ohnishi &Haruhiko Kishima, Automatic diagnosis of neurological diseases using MEG signals with a deep neural network, Scientific Reports volume 9, https://doi.org/10.1038/s41598-019-41500-xArticle number: 5057 (2019), Published 25 March 2019 media
Ryohei Fukuma, Takufumi Yanagisawa, Masataka Tanaka, Fumiaki Yoshida, Koichi Hosomi, Satoru Oshino, Naoki Tani and Haruhiko Kishima, Real-Time Neurofeedback to Modulate β-Band Power in the Subthalamic Nucleus in Parkinson’s Disease Patients,eNeuro 17 December 2018, 5 (6) ENEURO.0246-18.2018; DOI: https://doi.org/10.1523/ENEURO.0246-18.2018
Takufumi YANAGISAWA, Ryohei FUKUMA, Ben SEYMOUR, Koichi HOSOMI, Haruhiko KISHIMA, Takeshi SHIMIZU, Hiroshi YOKOI, Masayuki HIRATA, Toshiki YOSHIMINE, Yukiyasu KAMITANI, Youichi SAITOH., MEG–BMI to Control Phantom Limb Pain, Neurologia medico-chirurgica, Article ID st.2018-0099, [Advance publication] Released July 12, 2018, Online ISSN 1349-8029, Print ISSN 0470-8105
Fukuma R, Yanagisawa T, Yokoi H, Hirata M, Yoshimine T, Saitoh Y, Kamitani Y and Kishima H (2018) Training in Use of Brain–Machine Interface-Controlled Robotic Hand Improves Accuracy Decoding Two Types of Hand Movements. Front. Neurosci. 12:478. doi: 10.3389/fnins.2018.00478
Hashimoto H, Hirata M, Takahashi K, Kameda S, Katsuta Y, Yoshida F, Hattori N, Yanagisawa T, Palmer J, Oshino S, Yoshimine T, Kishima H., Non-invasive quantification of human swallowing using a simple motion tracking system. Sci Rep. 2018 Mar 23;8(1):5095. doi: 10.1038/s41598-018-23486-0.PMID:29572522
Toshihiko Araki#, Mai Onishi#, Takufumi Yanagisawa*, Masayuki Hirata, Yoshiyuki Watanabe, Soshiro Ogata, Kazu Honda, Mikio Watanabe, Yoshinori Iwatani, Shiro Yorifuji, Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution, Scientific Reports 7(1), 17660, 2017, Dec 15; #Contributed equally to this work, *Corresponding to this work
Hashimoto H, Hasegawa Y, Araki T, Sugata H, Yanagisawa T, Yorifuji S, Hirata M., Non-invasive detection of language-related prefrontal high gamma band activity with beamforming MEG., Scientific Reports., 2017; 7(1):14262. Doi:10.1038/s41598-017-14452-3. PMID:29079768
Izutsu N, Kinoshita M, Yanagisawa T, Nakanishi K, Sakai M, Kishima H., Preservation of Motor Function After Resection of Lower-Grade Glioma at the Precentral Gyrus and Prediction by Presurgical Functional Magnetic Resonance Imaging and Magnetoencephalography., World Neurosurg. 2017 Aug 4. pii: S1878-8750(17)31252-4. doi: 10.1016/j.wneu.2017.07.152.
Nakanishi Y*, Yanagisawa T*, Shin D, Kambara H, Yoshimura N, Tanaka M, Fukuma R, Kishima H, Hirata M, Koike Y, Mapping ECoG channel contributions to trajectory and muscle activity prediction in human sensorimotor cortex., Sci Rep. 2017 Mar 31; 7: 45486, DOI:10.1038/srep45486, *Contributed equally to this work
Kishima H, Kato A, Oshino S, Tani N, Maruo T, Khoo HM, Yanagisawa T, Edakawa K, Kobayashi M, Tanaka M, Hosomi K, Hirata M, Yoshimine T., Navigation-assisted trans-inferotemporal cortex selective amygdalohippocampectomy for mesial temporal lobe epilepsy; preserving the temporal stem., Neurol Res. 2017 Mar;39(3):223-230. doi: 10.1080/01616412.2016.1275458. Epub 2017 Jan 9. PMID:28067149
T. Yanagisawa, R. Fukuma, B. Seymour, K. Hosomi, H. Kishima, T. Shimizu, H. Yokoi, M. Hirata, T. Yoshimine, Y. Kamitani, Y. Saitoh, Induced sensorimotor brain plasticity controls pain in phantom limb patients, Nature Communications, 7, 13209 (2016) DOI;10.1038/NCOMMS13209
Araki T, Hirata M, Yanagisawa T, Sugata H, Onishi M, Watanabe Y, Ogata S, Honda C, Hayakawa K, Yorifuji S., Language-related cerebral oscillatory changes are influenced equally by genetic and environmental factors., Neuroimage. 2016 May 27. pii: S1053-8119(16)30186-0. doi: 10.1016/j.neuroimage.2016.05.066. PMID: 27241483
Edakawa K*, Yanagisawa T*, Kishima H, Fukuma R, Oshino S, Khoo HM, Kobayashi M, Tanaka M, Yoshimine T., Detection of Epileptic Seizures Using Phase-Amplitude Coupling in Intracranial Electroencephalography., Sci Rep. 2016 May 5;6:25422. doi: 10.1038/srep25422., PMID:27147119, *Contributed equally to this work
Fukuma R, Yanagisawa T*, Saitoh Y, Hosomi K, Kishima H, Shimizu T, Sugata H, Yokoi H, Hirata M, Kamitani Y, Yoshimine T, Real-Time Control of a Neuroprosthetic Hand by Magnetoencephalographic Signals from Paralysed Patients, Scientific Reports, 2016 Feb 24;6:21781. doi: 10.1038/srep21781.PMID:26904967 *Corresponding to this work
Kishima H, Yanagisawa T, Goto Y, Oshino S, Maruo T, Tani N, Khoo HM, Hosomi K, Hirata M, Yoshimine T., Respiratory Function Under Intrathecal Baclofen Therapy in Patients With Spastic Tetraplegia., Neuromodulation. 2016 Aug;19(6):650-4. doi: 10.1111/ner.12394. PMID:26833715, Epub 2016 Feb 2.
Tani N, Kishima H, Khoo HM, Yanagisawa T, Oshino S, Maruo T, Hosomi K, Hirata M, Kazui H, Nomura KT, Aly MM, Kato A, Yoshimine T., Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline., J Neurosurg., 15:1-8, 2016
Misaki Nakamura, Takufumi Yanagisawa*, Yumiko Okamura, Ryohei Fukuma, Masayuki Hirata, Toshihiko Araki, Yukiyasu Kamitani, Shiro Yorifuji, Categorical discrimination of human body parts by magnetoencephalography, Front. Hum. Neurosci., 04 Nov 2015 9:609. doi: 10.3389/fnhum.2015.00609. eCollection 2015.
Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh Y, Yoshimine T., Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus., J Neurosurg., 21:1-9, 2015, doi: 10.3171/2015.1.JNS141633. Epub 2015 Aug 21
Ryohei Fukuma, Takufumi Yanagisawa*, Shiro Yorifuji, Ryu Kato, Hiroshi Yokoi, Youichi Saitoh, Haruhiko Kishima, Masayuki Hirata, Yukiyasu Kamitani, Toshiki Yoshimine, Closed-Loop Control of a Neuroprosthetic Hand by Magnetoencephalographic Signals, PLoS One, 2015 Jul 2;10(7):e0131547. doi: 10.1371/journal.pone.0131547.
Proceedings of the Seventh International Workshop on Advances in Electrocorticography, Anthony Ritaccio, Riki Matsumoto, Martha Morrel, Kyousuke Kamada, Mohamad Koubeissi, David Poeppel, Jean-Philippe Lachaux, Takufumi Yanagisawa, Masayuki Hirata, Chirstoph Guger, Gerwin Schalk, Epilepsy and Behavior 51 (2015) 312-320
Morris S, Hirata M, Sugata H, Goto T, Matsushita K, Yanagisawa T, Saitoh Y, Kishima H, Yoshimine T., Patient Specific Cortical Electrodes for Sulcal and Gyral Implantation., IEEE Trans Biomed Eng. Vol.62, No.4, April, 1034-1041 2015
Shinshi M, Yanagisawa T**, Hirata M, Goto T, Sugata H, Araki T, Okamura Y, Hasegawa Y, S. Ihara A, Yorifuji S, Temporospatial Identification of Language-Related Cortical Function by a Combination of Transcranial Magnetic Stimulation and Magnetoencephalography, Brain and behavior, 2015 Mar;5(3):e00317. doi: 10.1002/brb3.317. Epub 2015 Jan 27. **Corresponding to this work, PMID 25642395
Kageyama Y, Hirata M, Yanagisawa T, Shimokawa T, Sawada J, Morris S, Mizushima N, Kishima H, Sakura O, Yoshimine T., Severely affected ALS patients have broad and high expectations for brain-machine interfaces., Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):513-9. doi: 10.3109/21678421.2014.951943. Epub 2014 Sep 10
Sugata H, Hirata M, Yanagisawa T, Shayne M, Matsushita K, Goto T, Yorifuji S, Yoshimine T., Alpha band functional connectivity correlates with the performance of brain-machine interfaces to decode real and imagined movements., Front Hum Neurosci. 2014 Aug 8;8:620. doi: 10.3389/fnhum.2014.00620. eCollection 2014.
Nakanishi Y*, Yanagisawa T*, Shin D, Chen C, Kambara H, Yoshimura N, Fukuma R, Kishima H, Hirata M, Koike Y., Decoding fingertip trajectory from electrocorticographic signals in humans., Neurosci Res. 2014 Aug;85:20-7. doi: 10.1016/j.neures.2014.05.005. Epub 2014 May 29. *Contributed equally to this work
Araki T, Hirata M, Sugata H, Yanagisawa T, Onishi M, Watanabe Y, Omura K, Honda C, Hayakawa K, Yorifuji S., Genetic and environmental influences on motor function: a magnetoencephalographic study of twins., Front Hum Neurosci. 2014 Jun 19;8:455. doi: 10.3389/fnhum.2014.00455. eCollection 2014.
Kishima H, Oshino S, Tani N, Maruo Y, Morris S, Ming Khoo H, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T., Which is the Most Appropriate Disconnection Surgery for Refractory Epilepsy In Childhood?, Neurol Med Chir (Tokyo). 2013: 53(11):814-20
Hosokawa S, Hirata M, Goto T, Yanagisawa T, Sugata H, Araki T, Okamura Y, Hasegawa Y, Shinshi M, Yorifuji S., Cerebellar-related long latency motor response in upper limb musculature by transcranial magnetic stimulationof the cerebellum, Neuroreport. 2014: Apr 16:25(6):353-7. Doi: 10.1097/WNR.0b013e32836377a6.
Nakanishi Y*, Yanagisawa T*, Shin D, Fukuma R, Chen C, Kambara H, Hirata M, Yoshimine T, Koike Y., Prediction of Three-Dimensional Arm Trajectories Based on ECoG Signals Recorded from Human Sensorimotor cortex, PLoS One. 2013 Aug 21; 8(8):e72085, *Contributed equally to this work
Yanagisawa T, Yamashita O, Hirata M, Kishima H, Saitoh Y, Goto T, Yoshimine T, Kamitani Y., Regulation of motor representation by phase-amplitude coupling in the sensorimotor cortex., J Neurosci. 2012 Oct 31; 32(44): 15467-75. Doi:10.1523/JNEUROSCI.2929-12.2012. PMID 23115184
Sugata H, Goto T, Hirata M, Yanagisawa T, Shayne M, Matsushita K, Yoshimine T, Yorifuji S. ,Neural decoding of unilateral upper limb movements using single trial MEG signals., Brain Res. 2012 Aug 15; 1468: 29-37. Epub 2012 Jun 8
Sugata H, Goto T, Hirata M, Yanagisawa T, Shayne M, Matsushita K, Yoshimine T, Yorifuji S., Movement-related neuromagnetic fields and performances of single trial classifications. Neuroreport 2012 Jan 4; 23(1):16-20
Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T, Electrocorticographic control of a prosthetic arm in paralyzed patients, Annals of Neurology, 2012, Mar:71 (3):353-61 Aug 19doi: 10.1002/ana.22613. Epub 2011 Nov 2.
Hirata M., Matsushita K., Suzuki T., Yoshida T., Sato F., Morris S., Yanagisawa T., Goto T. Kawato M., Yoshimine T., A fully-implantable wireless system for human brain-machine interfaces using brain surface electrodes: W-HERBS, IEICE Transactions on Communications, vol E94-B(9), pp.2448-2453, 2011
Saitoh Y, Yanagisawa T, Oshino S, Hirata M, Goto T, Hosomi K, Tani N, Yoshimine T, Analysis of cortical reorganization (CR) of the patients with phantom-limb pain and the mechanism of motor cortex stimulation, Neuroscience Research Vol 58, Supplement 1, 2007, Pp.S29
栁澤琢史、文献抄録 ‘High-performance neuroprosthetic control by an individual with tetraplegia’, No Sinkei Geka 41巻5号 2013年5月 pp461
Yanagisawa T, Yamashita O, Hirata M, Kishima H, Saitoh Y, Goto T, Yoshimine T, Kamitani Y., Phase-amplitude coupling in ECoG of sensorimotor cortex and its application to BMI, Functional neurosurgery 51 (2012) 33-37
Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T, Degeneration of ECoG signals in sensorimotor cortex of paralyzed patients, Functional neurosurgery, (in press)
Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Goto T, Fukuma R, Hosomi K, Yokoi H, Kamitani Y, Yoshimine T, Training-free control of robot by BMI using physiological characteristics of ECoG, Functional neurosurgery, Vol.49 No.2 2010, pp162-165
Yanagisawa T, Saitoh Y, Hosomi K, Hirata M, Kishima H, Oshino S, Goto T, Yoshimine T, Functional mapping in motor cortex of the patients with phantom limb pain, pain research, 24 (1) (2009) 31-36
Yanagisawa T, Saitoh Y, Hirata M, Yamashita O, Kamitani Y, Oshino S, Kishima H, Tani N, Hosomi K, Goto T, Sato M, Kakigi R, Yoshimine T, Mechanistic analysis of motor cortex stimulation for phantom limb pain, pain research, 23(1): 27-34, 2008
Yanagisawa T, Saito Y, Oshino S, Kizima H, Kato A, Sumitani A, Mashimo T, Yoshimine T, Examination of cortical reorganization with phantom limb pain by transcranial magnetic stimulation, magnetic encephalography and sensory evoked potential, pain research, 22: 143-148, 2007.
Brain-Computer Interface Research: A State-of-the-Art Summary -2, Christoph Guger, Brendan Allison, C. Leuthardt, SpringerBriefs in Electrical and Computer Engineering, 2013, pp.95-104, Takufumi Yanagisawa, Masayuki Hirata,Youichi Saitoh, Haruhiko Kishima, Kojiro Matsushita, Tetsu Goto, Ryohei Fukuma, Hiroshi Yokoi, Yukiyasu Kamitani, Toshiki Yoshimine, Electrocorticographic control of a prosthetic hand in paralyzed patients: ECoG Control of a Prosthetic Hand
Hirata M, Yanagisawa T, Kamitani Y, Yokoi H, Yoshimine T, Goto T, Fukuma R, Kato R Machine control device, machine system, machine control method, and recording medium storing machine control program 米国特許 出願人 Osaka University, ATR, The University of Tokyo 米国特許 米国出願番号 12/799,840 出願日 2010年5月3日 公開 US 2011/0218453 A1 取得 US8396546 取得日 2013年3月12日
Hirata M, Yoshimine T, Saitoh Y, Yanagisawa T, Goto T, Watanabe Y, Saito T Intracranial electrode and method for producing same 米国特許 出願人 Osaka Univ 米国特許 米国出願番号 12/378,695 出願日2009年2月18日 公開 US 2009/0228066 A1 公開日 2009年9月10日 取得 US7,860,577 取得日 2010年12月28日