184. Koga, R., Hamano, S., Kuwata, H., Atarashi, K., Ogawa, M., Hisaeda, H., Yamamoto, M., Akira, S., Himeno, K., Matsumoto, M., and Takeda, K.: TLR-dependent induction of IFN-b mediates host defense against Trypanosoma cruzi. J. Immunol. 177, 7059-7066 (2006).
183. Yamamoto, M., Okamoto, T., Takeda, K., Sato, S., Sanjo, H., Uematsu, S., Saitoh, T., Yamamoto, N., Sakurai, H., Ishii, K. J., Yamaoka, S., Kawai, T., Matsuura, Y., Takeuchi, O., and Akira, S.: Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 7, 962-970 (2006).
182. Uematsu, S., Jang, M. H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., Hemmi, H., Coban, C., Kawai, T., Ishii, K. J., Takeuchi, O., Miyasaka, M., Takeda, K., and Akira, S.: Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat. Immunol. 7, 868 - 874 (2006).
181. Yoshimatsu, T., Kawaguchi, D., Oishi, K., Takeda, K., Akira, S., Masuyama, N., and Gotoh, Y.: Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 33, 2553-2563 (2006).
180. Miyatsuka, T., Kaneto, H., Shiraiwa, T., Matsuoka, T. A., Yamamoto, K., Kato, K., Nakamura, Y., Akira, S., Takeda, K., Kajimoto, Y., Yamasaki, Y., Sandgren, E. P., Kawaguchi, Y., Wright, C. V., and Fujitani, Y.: Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 20, 1435-1440 (2006).
179. Takegahara, N., Takamatsu, H., Toyofuku, T., Tsujimura, T., Okuno, T., Yukawa, K., Mizui, M., Yamamoto, M., Prasad, D. V., Suzuki, K., Ishii, M., Terai, K., Moriya, M., Nakatsuji, Y., Sakoda, S., Sato, S., Akira, S., Takeda, K., Inui, M., Takai, T., Ikawa, M., Okabe, M., Kumanogoh, A., and Kikutani, H.: Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat. Cell Biol. 8, 615-622 (2006).
178. Nakamura, K., Miyagi, K., Koguchi, Y., Kinjo, Y., Uezu, K., Kinjo, T., Akamine, M., Fujita, J., Kawamura, I., Mitsuyama, M., Adachi, Y., Ohno, N., Takeda, K., Akira, S., Miyazato, A., Kaku, M. and Kawakami, K.: Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. FEMS Immunol. Med. Microbiol. 47, 148-154 (2006).
177. Yu, Q., Tang, C., Xun, S., Yajima, T., Takeda, K. and Yoshikai, Y.: MyD88-dependent signaling for IL-15 production is important for the development of CD8aaand TCRgd intestinal intraepithelial T lymphocytes. J. Immunol. 176, 6180-6185 (2006).
176. Inoue, H., Ogawa, W., Asakawa, A., OkamotoY., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, C. R., Noda, T., Takeda, K., Akira, S., Inui, A. and Kasuga, M.: Role of hepatic STAT3 in brain insulin action on hepatic glucose production. Cell Metab. 3, 267-75 (2006).
175. Kinoshita, D., Hirota, F., Kaisho, T., Kasai, M., Izumi, K., Bando, Y., Mouri, Y., Matsushima, A., Niki, S., Han, H., Oshikawa, K., Kuroda, N., Maegawa, M., Irahara, M., Takeda, K., Akira, S. and Matsumoto, M.: Essential role of IkB kinase a in thymic organogenesis required for the establishment of self-tolerance. J. Immunol. 176, 3995-4002 (2006).
174. Santos, L. L., Milenkovski, G. P., Hall, P. H., Leech, M., Sharma, L., Takeda, K., Akira, S., Kitching, A. R., and Morand, E. F.: IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. Immunol. Cell Biol. 84, 166-173 (2006).
173. Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J. and Yoshimoto, T.: IL-27 suppresses CD28-medicated IL-2 production through Suppressor of Cytokine Signaling 3. J. Immunol. 176, 2773-2780 (2006).
172. Kuwata, K., Matsumoto, M., Atarashi, K., Morishita, H., Hirotani, T., Koga, R., and Takeda, K.: IkBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity 24, 41-51 (2006).
171. Ogawa, A., Tagawa, T., Nishimura, H., Yajima, T., Abe, T., Arai, T., Taniguchi, M., Takeda, K., Akira, S., Nimura, Y., and Yoshikai, Y.: Toll-like receptors 2 and 4 are differentially involved in Fas-dependent apoptosis in Peyers patch and liver at an early stage after bile duct ligation in mice. Gut 5, 105-113 (2006).
170. Bhattacharjee, R. N., Park, K. S., Uematsu, S., Okada, K., Hoshino, K., Takeda, K., Takeuchi, O., Akira, S., Iida, T., and Honda, T.: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. FEBS Lett. 79, 6604-6610 (2005).
169. Wieland, C. W., Florquin, S., Maris, N. A., Hoebe, K., Beutler, B., Takeda, K., Akira, S., and van der Poll, T.: The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J. Immunol. 175, 6042-6049 (2005).
168. Sato, S., Sanjo, H., Takeda, K., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O., and Akira, S.: Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6, 1087-1095 (2005).
167. Haga, S., Ogawa, W., Inoue, H., Terui, K., Ogino, T., Igarashi, R., Takeda, K., Akira, S., Enosawa, S., Furukawa, H., Todo, S., and Ozaki, M.: Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice. J. Hepatol. 43, 799-807 (2005).
166. Yukawa, K., Tanaka, T., Owada-Makabe, K., Tsubota, Y., Bai, T., Maeda, M., Takeda, K., Akira, S., and Iso, H.: Reduced prepulse inhibition of startle in STAT6-deficient mice. Int. J. Mol. Med. 16, 673-675 (2005).
165. Matsukawa, A., Kudo, S., Maeda, T., Numata, K., Watanabe, H., Takeda, K., Akira, S., and Ito, T.: Stat3 in resident macrophages as a repressor protein of inflammatory response. J. Immunol. 175, 3354-3359 (2005).
164. Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., and Akira, S.: Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28 (2005).
163. Ohkawara, T., Takeda, H., Nishihira, J., Miyashita, K., Nihiwaki, M., Ishiguro, Y., Takeda, K., Akira, S., Iwanaga, T., Sugiyama, T., and Asaka, M. Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice. Clin. Exp. Immunol. 141, 412-421 (2005).
162. Weiss, D. S., Takeda, K., Akira, S., Zychlinsky, A., and Moreno, E.: MyD88, but not Toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus. Infect. Immun. 73, 5137-5143 (2005).
161. Yang, S., Takahashi, N., Yamashita, T., Sato, N., Takahashi, M., Mogi, M., Uematsu, T., Kobayashi, Y., Nakamichi, Y., Takeda, K., Akira, S., Takada, H., Udagawa, N., and Furusawa, K.: Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1b, and TNF-a through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts. J. Immunol. 175, 1956-1964 (2005).
160. Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., and Shimizu, T.: Priming effect of lipopolysaccharide on acetyl-coenzyme A: lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent. J. Immunol. 175, 1177-1183 (2005).
159. Kitching, A. R., Turner, A. L., Wilson, G. R., Semple, T., Odobasic, D., Timoshanko, J. R., O'sullivan, K. M., Tipping, P. G., Takeda, K., Akira, S., and Holdsworth, S. R.: IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J. Am. Soc. Nephrol. 16, 2023-2033 (2005).
158. Yang, R., Murillo, F. M., Delannoy, M. J., Blosser, R. L., Yutzy, W. H. 4th, Uematsu, S., Takeda, K., Akira, S., Viscidi, R. P., Roden, R. B.: B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J. Immunol. 174, 7912-7919 (2005).
157. Yang, R., Wheeler, C. M., Chen, X., Uematsu, S., Takeda, K., Akira, S., Pastrana, D. V., Viscidi, R. P., and Roden, R. B.: Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer. J. Virol. 79, 6741-6750 (2005).
156. Xu, A. W., Kaelin, C. B., Takeda, K., Akira, S., Schwartz, M. W., and Barsh, G. S.: PI3K integrates the action of insulin and leptin on hypothalamic neurons. J. Clin. Invest. 115, 951-958 (2005).
155. Yukawa, K., Iso, H., Tanaka, T., Tsubota, Y., Owada-Makabe, K., Bai, T., Takeda, K., Akira, S., and Maeda, M.: Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice. Int. J. Mol. Med. 15, 819-825 (2005).
154. Kumanogoh, A., Shikina, T., Suzuki, K., Uematsu, S., Yukawa, K., Kashiwamura, S., Tsutsui, H., Yamamoto, M., Takamatsu, H., Ko-Mitamura, E. P., Takegahara, N., Marukawa, S., Ishida, I., Morishita, H., Prasad, D. V., Tamura, M., Mizui, M., Toyofuku, T., Akira, S., Takeda, K., Okabe, M., and Kikutani, H.: Nonredundant roles of Sema4A in the immune system: Defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. Immunity 22, 305-316 (2005).
153. Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., and Takeda, K.: The nuclear IkB protein IkBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J. Immunol. 174, 3650-3657 (2005).
152. Araki, A., Kanai, T., Ishikura, T., Makita, S., Uraushihara, K., Iiyama, R., Totsuka, T., Takeda, K., Akira, S., and Watanabe, M.: MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J. Gastroenterol. 40, 16-23 (2005).
151. Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Kakumitsu, H., Yoshie, M., Yamamoto, M., Takeda, K., Matsuda, T., Akira, S., Ogawa, K., and Harada, M.: Roles of Stat3 and ERK in G-CSF Signaling. Stem Cells 23, 252-263 (2005).
150. Yukawa, K., Kishino, M., Goda, M., Liang, X. M., Kimura, A., Tanaka, T., Bai, T., Owada-Makabe, K., Tsubota, Y., Ueyama, T., Ichinose, M., Maeda, M., Takeda, K., and Akira, S.: STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Int. J. Mol. Med. 15, 225-230 (2005).
149. Akamine, M., Higa, F., Arakaki, N., Kawakami, K., Takeda, K., Akira, S., and Saito, A.: Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila. Infect. Immun. 73, 352-361 (2005).
148. Yukawa, K., Kishino, M., Hoshino, K., Shirasawa, N., Kimura, A., Tsubota, Y., Owada-Makabe, K., Bai, T., Tanaka, T., Ueyama, T., Ichinose, M., Takeda, K., Akira, S., and Maeda, M.: The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy. Int. J. Mol. Med. 15, 73-78 (2005).
147. Wieland, C. W., Knapp, S., Florquin, S., De Vos, A. F., Takeda, K., Akira, S., Golenbock, D. T., Verbon, A., and Van Der Poll, T.: Non-mannose-capped lipoarabinomannan induces lung inflammation via Toll-like receptor 2. Am. J. Respir. Crit. Care Med. 170, 1367-1374 (2004).
146. Chaisson, M. L., Branstetter, D. G., Derry, J. M., Armstrong, A. P., Tometsko, M. E., Takeda, K., Akira, S., and Dougall, W. C.: Osteoclast differentiation is impaired in the absence of IKKa. J. Biol. Chem. 279, 54841-54848 (2004).
145. Sumi, K., Yokozeki, H., Wu, M. H., Satoh, T., Kaneda, Y., Takeda, K., Akira, S., and Nishioka, K.: In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity. Gene Ther. 11, 1763-1771 (2004).
144. Yokozeki, H., Wu, M. H., Sumi, K., Awad, S., Satoh, T., Katayama, I., Takeda, K., Akira, S., Kaneda, Y., and Nishioka, K.: In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model. Gene Ther. 11, 1753-1762 (2004).
143. Vossenkamper, A., Went, T., Alvarado-Esquivel, C., Takeda, K., Akira, S., Pfeffer, K., Alber, G., Lochner, M., Forster, I. and Liesenfeld, O: Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii but IL-12 is dominant over IL-18 in parasite control. Eur. J. Immunol. 34, 3197-3207 (2004).
142. Yang, R., Murillo, F. M., Cui, H., Blosser, R., Uematsu, S., Takeda, K., Akira, S., Viscidi, R. P., and Roden, R. B.: Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88. J. Virol. 78, 11152-1160 (2004).
141. Nakasone, C., Kawakami, K., Hoshino, T., Kawase, Y., Yokota, K., Yoshino, K., Takeda, K., Akira, S., and Saito, A.: Limited role for interleukin-18 in the host protection response against pulmonary infection with Pseudomonas aeruginosa in mice. Infect. Immun. 72, 6176-6180 (2004).
140. Sato, N., Takahashi, N., Suda, K., Nakamura, M., Yamaki, M., Ninomiya, T., Kobayashi, Y., Takada, H., Shibata, K., Yamamoto, M., Takeda, K., Akira, S., Noguchi, T., and Udagawa, N.: MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1a. J. Exp. Med. 200, 601-611 (2004).
139. Yang, R., Murillo, F. M., Lin, K.-Y., Yutzy IV, W. H., Uematsu, S., Takeda, K., Akira, S., Viscidi, R. P., and Roden, R. B. S.: Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations. J. Immunol. 173, 2624-2631 (2004).
138. Okamoto, M., Furuichi, S., Nishioka, Y., Oshikawa, T., Tano, T., Ahmed, S. U., Takeda, K., Akira, S., Ryoma, Y., Moriya, Y., Saito, M., Sone, S., and Sato, M.: Expression of Toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a Streptococcal preparation. Cancer Res. 64, 5461-5470 (2004).
137. Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Kuwata, H., Yamamoto, S., Takeuchi, O., Takeshige, K., Saito, T., Yamaoka, S., Yamamoto, N., Muta, T., Takeda, K., and Akira, S.: Regulation of Toll/IL-1 receptor-mediated gene expression by the inducible nuclear protein IkBz. Nature 430, 218-222 (2004).
136. Kishino, M., Yukawa, K., Hoshino, K., Kimura, A., Shirasawa, N., Otani, H., Tanaka, T., Owada-Makabe, K., Tsubota, Y., Maeda, M., Ichinose, M., Takeda, K., Akira, S., and Mune, M.: Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury. J. Am. Soc. Nephrol. 15, 1826-1834 (2004)
135. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., and Akira, S.: The roles of two IkB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650 (2004).
134. Gorogawa, S., Fujitani, Y., Kaneto, H., Hazama, Y., Watada, H., Miyamoto, Y., Takeda, K., Akira, S., Magnuson, M. A., Yamasaki, Y., Kajimoto, Y., and Hori, M.: Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem. Biophys. Res. Commun. 319, 1159-1170 (2004).
133. Kawakami, K., Kinjo, Y., Uezu, K., Miyagi, K., Kinjo, T., Yara, S., Koguchi, Y., Miyazato, A., Shibuya, K., Iwakura, Y., Takeda, K., Akira, S., and Saito, A.: Interferon-g production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18. Microbes. Infect. 6, 339-349 (2004).
132. Ikushima, H., Nishida, T., Takeda, K., Ito, T., Yasuda, T., Yano, M., Akira, S., and Matsuda, H.: Expression of Toll-like receptors 2 and 4 is down-regulated after operation. Surgery 135, 376-385 (2004).
131. Li, Y., Ishii, K., Hisaeda, H., Hamano, S., Zhang, M., Nakanishi, K., Yoshimoto, T., Hemmi, H., Takeda, K., Akira, S., Iwakura, Y., and Himeno, K.: IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9? Gene Ther. 11, 941-948 (2004).
130. Weiss, D. S., Raupach, B., Takeda, K., Akira, S., and Zychlinsky, A.: Toll-like receptors are temporally involved in host defense. J. Immunol. 172, 4463-4469 (2004).
129. Yukawa, K., Hoshino, K., Kishino, M., Mune, M., Shirasawa, N., Kimura, A., Tsubota, Y., Owada-Makabe, K., Tanaka, T., Ichinose, M., Maeda, M., Takeda, K., and Akira S.: Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy. Int. J. Mol. Med. 13, 515-520 (2004).
128. Robben, P. M., Mordue, D. G., Truscott, S. M., Takeda, K., Akira, S., and Sibley, L. D.: Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J. Immunol. 172, 3686-3694 (2004).
127. Liu, B., Mori, I., Hossain, M. J., Dong, L., Takeda, K., and Kimura, Y.: Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J. Gen. Virol. 85, 423-428 (2004).
126. Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., Iguchi, H., Hiramatsu, R., Leroith, D., Takeda, K., Akira, S., and Kasuga, M.: Role of Stat3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 10, 168-174 (2004).
125. Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., and Raz, E.: Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126, 520-528 (2004).
124. Akazawa, T., Masuda, H., Saeki, Y., Matsumoto, M., Takeda, K., Tsujimura, K., Kuzushima, K., Takahashi, T., Azuma, I., Akira, S., Toyoshima, K., and Seya, T.: Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice. Cancer Res. 64, 757-764 (2004).
123. Into, T., Kiura, K., Yasuda, M., Kataoka, H., Inoue, N., Hasebe, A., Takeda, K., Akira, S., and Shibata, K.: Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kB activation. Cell. Microbiol. 6, 187-199 (2004).
122. Hokuto, I., Ikegami, M., Yoshida, M., Takeda, K., Akira, S., Perl, A. T., Hull, W. M., and Whitsett, J. A.: Stat-3 is required for pulmonary homeostasis during hyperoxia. J. Clin. Invest. 113, 28-37 (2004).
