2023
307. Nakatani A, Okumura R, Ishibashi A, Okamoto S, Sakaki K, Ito Y, Okuzaki D, Inohara H, Takeda K: Differential dependence on microbiota of IL-23/IL-22-dependent gene expression between the small- and large-intestinal epithelia. Genes Cells in press
306. Taniguchi M, Okumura R, Matsuzaki T, Nakatani A, Sakaki K, Okamoto S, Ishibashi A, Tani H, Horikiri M, Kobayashi N, Yoshikawa HY, Motooka D, Okuzaki D, Nakamura S, Kida T, Kameyama A, Takeda K: Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Mucosal Immunol 16, 624-641 (2023).
305. Tomofuji Y, Sonehara K, Kishikawa T, Maeda Y, Ogawa K, Kawabata S, Nii T, Okuno T, Oguro-Igashira E, Kinoshita M, Takagaki M, Yamamoto K, Kurakawa T, Yagita-Sakamaki M, Hosokawa A, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Ohshima S, Nakamura S, Inohara H, Kishima H, Mochizuki H, Takeda K, Kumanogoh A, Okada Y.: Reconstruction of the personal information from human genome reads in gut metagenome sequencing data. Nat Microbiol. 8, 1079-1094 (2023).
304. Chalalai T, Kamiyama N, Saechue B, Sachi N, Ozaka S, Ariki S, Dewayani A, Soga Y, Kagoshima Y, Ekronarongchai S, Okumura R, Kayama H, Takeda K, Kobayashi T.: TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses. Biochem Biophys Res Commun. 20, 103-112 (2023).
303. Nii T, Maeda Y, Motooka D, Naito M, Matsumoto Y, Ogawa T, Oguro-Igashira E, Kishikawa T, Yamashita M, Koizumi S, Kurakawa T, Okumura R, Kayama H, Murakami M, Sakaguchi T, Das B, Nakamura S, Okada Y, Kumanogoh A, Takeda K: Genomic repertoires linked with pathogenic potency of arthritogenic Prevotella copri isolated from the gut of rheumatoid arthritis patients. Annals Rheum. Dis. 82, 621-629 (2023).
2022
302. Yokoi T, Murakami M, Kihara T, Seno S, Arase M, Wing JB, Søndergaard JN, Kuwahara R, Minagawa T, Oguro-Igashira E, Motooka D, Okuzaki D, Mori R, Ikeda A, Sekido Y, Amano T, Iijima H, Ozono K, Mizushima T, Hirota S, Ikeuchi H, Takeda K: Identification of a unique subset of tissue resident memory CD4+ T cells in Crohn's disease. Proc. Natl. Acad. Sci. USA 120, e2204269120 (2023).
301. Tomofuji Y, Kishikawa T, Maeda Y, Ogawa K, Otake-Kasamoto Y, Kawabata S, Nii T, Okuno T, Oguro-Igashira E, Kinoshita M, Takagaki M, Oyama N, Todo K, Yamamoto K, Sonehara K, Yagita M, Hosokawa A, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Ohshima S, Shinzaki S, Nakamura S, Iijima H, Inohara H, Kishima H, Takehara T, Mochizuki H, Takeda K, Kumanogoh A, Okada Y. Prokaryotic and viral genomes recovered from 787 Japanese gut metagenomes revealed microbial features associated with diets, populations, and diseases. Cell Genomics 2, 100219 (2022).
300. Nakagawa N, Kayama H, Okumura R, Nakajima H, Minagawa H, Morimoto S, Fujiki F, Nakata J, Oji Y, Oka Y, Takeda K, Ozono K, Tsuboi A, Hashii Y: An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia. Cancer Immunol. Immunother in press
299. Maeda Y, Motooka D, Kawasaki T, Oki H, Noda Y, Adachi Y, Niitsu T, Okamoto S, Tanaka K, Fukushima K, Amiya S, Hara R, Oguro-Igashira E, Matsuki T, Hirata H, Takeda Y, Kida H, Kumanogoh A, Nakamura S,Takeda K: Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity. BMC Infect Dis 22, 572 (2022).
298. Otake-Kasamoto Y, Kayama H, Kishikawa T, Shinzaki S, Tashiro T, Amano T, Tani M, Yoshihara T, Li B, Tani H, Liu L, Hayashi A, Okuzaki D, Motooka D, Nakamura S, Okada Y, Iijima H, Takeda K, Takehara T.: Lysophosphatidylserines derived from microbiota in Crohn's disease elicit pathological Th1 response. J. Exp. Med. 219, e20211291 (2022).
297. Matsushita M, Fujita K, Hatano K, Hayashi T, Kayama H, Motooka D, Hase H, Yamamoto A, Uemura T, Yamamichi G, Tomiyama E, Koh Y, Kato T, Kawashima A, Uemura M, Nojima S, Imamura R, Mubeen A, Netto GJ, Tsujikawa K, Nakamura S, Takeda K, Morii E, Nonomura N.: High-fat diet promotes prostate cancer growth through histamine signaling. Int. J. Cancer. 151, 623-636 (2022)
296. Liu Q, Umemoto E, Morita N, Kayama H, Baba Y, Kurosaki T, Okumura R, Takeda K: Pyruvate enhances oral tolerance via GPR31. Int Immunol. 34, 343-352 (2022).
295. Pareek S, Sanchenkova X, Sakaguchi T, Murakami M, Okumura R, Kayama H, Kawauchi S, Motooka D, Nakamura S, Okuzaki D, Kishimoto T, Takeda K: Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine. Genes Cells 27, 243-253 (2022).
294. Watanabe Y, Mizushima T, Okumura R, Fujino S, Ogino T, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Yamamoto H, Takeda K, Doki Y, Eguchi H.: Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn's Disease. Dig. Dis. Sci. 67, 2143-2157 (2022).
293. Lu X, Oh-hora M, Takeda K, Yamasaki S: Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB. Int. Immunol. 34, 197-206 (2022).
292. Tomofuji Y, Kishikawa T, Maeda Y, Ogawa K, Nii T, Okuno T, Oguro-Igashira E, Kinoshita M, Yamamoto K, Sonehara K, Yagita M, Hosokawa A, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Ohshima S, Nakamura S, Inohara H, Mochizuki H, Takeda K, Kumanogoh A, Okada Y. :A whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease. Annals Rhem Dis. 81, 278-288 (2022).
2021
291. Tomofuji Y, Maeda Y, Oguro-Igashira E, Kishikawa T, Yamamoto K, Sonehara K, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Yagita M, Nii T, Ohshima S, Nakamura S, Inohara H, Takeda K, Kumanogoh A, Okada Y.: Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese. Annals Rhem Dis. 80, 1575-1583 (2021).
290. Caldwell H, Yang C, Lei L, Collins J, Briones M, Ma L, Sturdevant G, Su H, Kashyap A, Dorward D, Bock K, Moore I, Bonner C, Chen C-Y, Martens C, Recklefs S, Yamamoto M, Takeda K, Iwakura Y, McClarty G.: Chlamydia evasion of neutrophil host defense results in macrophage-associated sterile inflammation through the purinergic P2X7 receptor. Nat Comm. 12, 5454 (2021)
289. Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.: Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. J Exp Med. 18: e20211327 (2021).
288. Ozaka S, Sonoda A, Ariki S, Kamiyama N, Hidano S, Sachi N, Ito K, Kudo Y, Minata M, Saechue B, Dewayani A, Chalalai T, Soga Y, Takahashi Y, Fukuda C, Mizukami K, Okumura R, Kayama H, Murakami K, Takeda K, Kobayashi T: Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier. Genes Cells 26, 807-822 (2021).
287. Tani H, Li B, Kusu T, Okumura R, Nishimura J, Okuzaki D, Motooka D, Arakawa S, Yoshihara T, Ogino T, Tsai SH, Furuta Y, Muneta M, Nakamura S, Fukusaki E, Yamamoto K, Yagita H, Kayama H Takeda K: The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells. Proc. Natl. Acad. Sci. USA 118, e2100594118, (2021).
286. Matsushita M, Hayashi T, Kayama H, Motooka D, Hase H, Jingushi K, Yamamichi G, Yumiba S, Tomiyama E, Koh Y, Hayashi Y, Nakano K, Wang C, Ishizuya Y, Kato T, Hatano K, Kawashima A, Ujike T, Uemura M, Imamura R, Pena MD, Gordetsky JB, Netto GJ, Tsujikawa K, Nakamura S, Takeda K, Nonomura N: Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling. Cancer Res. 81, 4014-4026 (2021).
285. Okiyama N, Ichimura Y, Shobo M, Tanaka R, Kubota N, Saito A, Ishitsuka Y, Watanabe R, Fujisawa Y, Nakamura Y, Murakami A, Kayama H, Takeda K, Fujimoto M: Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ, can result in experimental myositis. Annals Rhem Dis 80, 1201-1208 (2021).
284. Hsu CC, Okumura R, Motooka D, Sasaki R, Nakamura S, Iida T, Takeda K: Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel diseases. Int. Immunol. 18, 359-372 (2021).
283. Kishikawa T, Maeda Y, Nii T, Arase N, Hirata J, Suzuki K, Yamamoto K, Masuda T, Ogawa K, Tsuji S, Matsushita M, Matsuoka H, Yoshimura M, Tsunoda S, Ohshima S, Narazaki M, Ogata A, Saeki Y, Inohara H, Kumanogoh A, Takeda K, Okada Y: Increased levels of plasma nucleotides in patients with rheumatoid arthritis. Int Immunol. 3, 119-124 (2021).
282. Ogawa T, Okumura R, Nagano K, Minemura T, Izumi M, Motooka D, Nakamura S, Iida T, Maeda Y, Kumanogoh A, Tsutsumi Y, Takeda K: Oral intake of silica nanoparticles exacerbates intestinal inflammation. Biochem Biophys Res Commun. 534, 540-546 (2021).
2020
281. Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, Isobe J, Yamada T, Muroi K, Yanagisawa Y, Nakamura A, Fujimura Y, Saeki A, Ueda M, Matsumoto R, Asaoka H, Clarke JM, Harada Y, Umemoto E, Komatsu N, Okada T, Takayanagi H, Takeda K, Tomura M, Hase K.: Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 58, 102913 (2020)
280. Yasueda A, Kayama H, Murohashi M, Nishimura J, Wakame K, Komatsu KI, Ogino T, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Kitagawa T, Takeda K, Ito T, Doki Y, Eguchi H, Shimizu S, Mizushima T: Sanguisorba Officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in innate myeloid cells. Sci. Rep. 10, 9972 (2020)
279. Ara T, Hashimoto D, Hayase E, Noizat C, Kikuchi1 R, Hasegawa Y, Matsuda K, Ono S, Matsuno Y, Ebata K, Ogasawara R, Takahashi S, Ohigashi H, Yokoyama H, Matsuo K, Sugita J, Onozawa M, Okumura R, Takeda K, Teshima T: Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8. Sci. Trans. Med. 12, 550, eaaw0720 (2020)
278. Sakaguchi T, Okumura R, Ono C, Okuzaki D, Kawai D, Okochi Y, Tanimura N, Murakami M, Kayama H, Umemoto E, Kioka H, Ohtani T, Sakata Y, Miyake K, Okamura Y, Baba Y, Takeda K: TRPM5 negatively regulates calcium-dependent responses in lipopolysaccharide-stimulated B lymphocytes. Cell Reports 10, 107755 (2020)
277. Ikeda A, Ogino T, Kayama H, Okuzaki D, Nishimura J, Fujino S, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Yamamoto H, Takeda K, Mizushima T, Mori M, Doki Y: Human NKp44+ ILC3 character associated with induction of tumor-associated tertiary lymphoid structures is altered in T3/T4 colorectal cancer. Cancer Immunol. Res. 8, 724-731 (2020)
276. Iwatani S, Iijima H, Otake Y, Amano T, Tani M, Yoshihara T, Tashiro T, Tsujii Y, Inoue T, Hayashi Y, Takeda K, Hayashi A, Fujita S, Shinzaki S, Takehara T: Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease. J. Gastroentrol. Hepatol. 35, 1355-1364 (2020)
275. Matsuoka S, Hashimoto D, Kadowaki M, Ohigashi H, Hayase E, Aoyama K, Onozawa M, Takeda K, Akashi K, Teshima T: The myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease. Haematologica 105, 226-234 (2020)
2019
274. Sekido Y, Nishimura J, Nakano K, Osu T, Chow CT, Matsuno H, Ogino T, Fujino S, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Kayama H, Mori M, Doki Y, Takeda K, Uchino M, Ikeuchi H, Mizushima T. Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn's disease patients versus mucus. Sci. Rep. 10, 2988 (2019)
273. Pareek S, Kurakawa T, Das B, Motooka D, Nakaya S, Rongsen-Chandola T, Goyal N, Kayama H, Dodd D, Okumura R, Maeda Y, Fujimoto K, Nii T, Ogawa T, Iida, Bhandari N, Kida T, Nakamura S, Nair GB, Takeda K. Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi. NPJ Biofilms Microbiomes 5, 37 (2019)
272. Okumura R, Kodama T, Hsu CC, Sahlgren BH, Hamano S, Kurakawa T, Iida T, Takeda K. Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia. Mucosal Immunol 13, 75-85 (2020)
271. Kishikawa A, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, Matsuoka H, Yoshimura M, Kawada S, Teshigawara S, Oguro E, Okita Y, Kawamoto K, Higa S, Hirano T, Narazaki M, Ogata A, Saeki Y, Nakamura S, Inohara H, Kumanogoh A, Takeda K, Okada Y. Metagenome-wide association study of gut microbiome revealed novel etiology of rheumatoid arthritis in the Japanese population. Ann Rheum Dis. 79, 103-111 (2020)
270. Simmons S, Sasaki N, Umemoto E, Uchida Y, Fukuhara S, Kitazawa Y, Okudaira M, Inoue A, Tohya K, Aoi K, Aoki J, Mochizuki N, Matsuno K, Takeda K, Miyasaka M, Ishii M. High-endothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in the lymph node. eLife. 8. pii: e41239 (2019)
269. Kayama H, Tani H, Kitada S, Opasawatchai A, Okumura R, Motooka D, Nakamura S, Takeda K: BATF2 prevents T cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway. Int. Immunol. 31, 371-383 (2019)
268. Orimo T, Sasaki I, Hemmi H, Ozawa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama K, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T: Cholera toxin B induces interleukine-1 production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.Int. Immunol. 31, 657-668 (2019)
267. Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K: GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites. Nature.566,110-114 (2019).
2018
266. Sekido Y, Yasumizu Y, Nishimura J, Kayama H, Matsuno H, Ogino T, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Takeda K, Ohkura N, Sakaguchi S, Mizushima T.: Innate myeloid cell subset-specific gene expression patterns in the human colon are altered in Crohn’s disease patients. Digestion. 19, 1-11 (2018).
265. Fukata T, Mizushima T, Nishimura J, Okuzaki D, Wu X, Hirose H, Yokoyama Y, Kubota Y, Nagata K, Tsujimura N, Inoue A, Miyoshi N, Haraguchi N, Takahashi H, Hata T, Matsuda C, Kayama H, Takeda K, Doki Y, Mori M, Yamamoto H: Supercarbonate apatite-microRNA complex inhibits dextran sodium sulfate-induced colitis. Mol Ther Nuc Acids 12, 658-671 (2018).
264. Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K: Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with non-inflammatory profiles. Proc. Natl. Acad. Sci. USA 115, 8418-8423 (2018).
263. Katsimichas T, Ohtani T, Motooka D, Tsukamoto Y, Kioka H, Nakamoto K, Konishi S, Chimura M, Sengoku K, Miyawaki H, Sakaguchi T, Okumura R, Theofilis K, Iida T, Takeda K, Nakamura S, Sakata Y: Non-ischemic heart failure with reduced ejection fraction is associated with altered intestinal microbiota. Circulation J. 82, 1640-1650 (2018).
262. Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, Kurosak T: T follicular helper cell-germinal center B cell interaction strength regulates entry into plasma cell or recycling germinal center cell fate. Immunityy 48, 702-715 (2018).
2017
261. Ando T, Kashiwakura JI, Itoh-Nagato N, Yamashita H, Baba M, Kawakami Y, Tsai SH, Inagaki N, Takeda K, Iwata T, Shimojo N, Fujisawa T, Nagao M, Matsumoto K, Kawakami Y, Kawakami T.: Histamine-releasing factor enhances food allergy. J Clin Invest127, 4541-4553 (2017).
260. Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, and Takeda K: Slc3a2 mediates branched-chain amino acid-dependent maintenance of regulatory T cells. Cell Reports21, 1824-1838 (2017).
259. *Cao W, *Kayama H (*: equal contribution), Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, HommesDW, Koralov SB, Takeda K, Sundrud, MS: The xenobiotic transporter Mdr1 permitsT cell adaptation to bile acid reabsorption in the ileum. Immunity 47, 1182-1196 (2017).
258. Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, and Kumanogoh A:The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy. Nat Med. 23,1524-1534 (2017).
257. Hsu, CC, Okumura R, Takeda K: Human LYPD8 protein inhibits motility of flagellated bacteria. Inflamm Regeneration 37, 23 (2017).
256. Matsuno H, Kayama H, Nishimura J, Sekido Y, Osawa H, Barman S, Ogino T, Takahashi H, Haraguchi N, Hata T, Matsuda C, Yamamoto H, Uchino M, Ikeuchi H, Doki Y, Mori M, Takeda K, Mizushima T. CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis. Inflamm Bowel Dis. 23,1524-1534 (2017)
255. Kitada S, Kayama H, Okuzaki D, Koga R, Kobayashi M, Arima Y, Kumanogoh A, Murakami M, Ikawa M and Takeda K: BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J. Exp. Med 214, 1313-1331 (2017).
254. Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H and Takeda K: E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLOS ONE 12, e0172509 (2017).
253. Motooka D, Fujimoto K, Tanaka R, Yaguchi T, Gotoh K, Maeda Y, Furuta Y, Kurakawa T, Goto N, Yasunaga T, Narazaki M, Kumanogoh A, Horii T, Iida T, Takeda K, and Nakamura S.: Fungal ITS1 deep-sequencing strategies to reconstruct the composition of a 26-species community and evaluation of thegut mycobiota of healthy Japanese individuals. Front. Microbiol. 8, 238 (2017)
252. Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K and Nakajima H: IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy72, 1043-1053 (2017)
2016
251. Barman S, Kayama H, Okuzaki D, Ogino T, Osawa H, Matsuno H, Mizushima T, Mori M, Nishimura J and Takeda K: Identification of a human intestinal myeloid cell subset that regulates the gut homeostasis. Int. Immunol. 28, 533-545 (2016)
250. Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, and Takeda K: Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol 10, 446-445 (2017).
249. Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K: Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheum 68, 2646-2661 (2016).
248. Kawano H, Kayama H, Nakama T, Hashimoto T, Umemoto E, and Takeda K: IL-10-producing lung interstitial macrophages prevent neutrophilic asthma. Int. Immunol. 28, 489-501 (2016).
247. Bag S, Saha B, Mehta O, Anbumani D, Kumar N, Dayal M, Pant A, Kumar P, Saxena S, Allin KH, Hansen T, Arumugam M, Vestergaard H, Pedersen O, Pereira V, Abraham P, Tripathi R, Wadhwa N, Bhatnagar S, Prakash VG, Radha V, Anjana RM, Mohan V, Takeda K, Kurakawa T, Nair GB, Das B.: An improved method for high quality metagenomics DNA extraction from human and environmental samples. Sci. Rep. 6, 26775 (2016).
246. Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K: Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532, 117-121 (2016).
245. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi M, Tohya K, Inoue A, Hata E, Akahoshi , Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, and Umemoto E: Fibroblastic reticular cell-derived lysophosphatidic acid regulatesconfined intranodal T-cell motility. eLife 5, e10561 (2016).
2015
244. Ohshima, J., Sasai, M., Liu, J., Yamashita, K., Ma, J.S., Lee, Y., Bando, H., Howard, J.C., Ebisu, S., Hayashi, M., Takeda K, Standley, D.M., Frickel, E.M., and Yamamoto, M.: RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci USA 112, 4581-4590 (2015).
243. Chinen I, Nakahama T, Kimura A, Nguyen NT, Takemori H, Kumagai A, Kayama H, Takeda K, Lee S, Hanieh H, Ripley B, Millrine D, Dubey PK, Nyati KK, Fujii-Kuriyama Y, Chowdhury K, Kishimoto T.: The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis. Int. Immunol.27, 405-415 (2015).
242. Kashiwagi, I., Morita, R., Shichita, T., Komai, K., Saeki, K., Matsumoto, M., Takeda K, Nomura, M., Hayashi, A., Kanai, T. and Yoshimura, A.: Smad2 and Smad3 inversely regulate TGF-β autoinduction in Clostridium butyricum-activated dendritic cells. Immunity 43, 65-79 (2015).
241. Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda K and Kikuchi, A.: The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. Sci. Rep.. 5, 10536 (2015).
240. Tsai, S. H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada, Y., Takeda, A., Yoshikawa, S., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H. and Takeda K: Ectoenzyme E-NPP3 (CD203c) negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity 42, 279-293 (2015).
2014
239. Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda K, Kurosaki, T., and Baba, Y.: Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.
Immunity 41,1040-1051 (2014).
238. Kobayashi, S., Hara, A., Isagawa, T., Manabe, I., Takeda K and Maruyama, T.: The nuclear IkB family protein IkBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One 9, e110838 (2014).
237. Ma, J. S., Sasai, M., Ohshima, J., Lee, Y., Bando, H., Takeda K and Yamamoto, M.: Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. J. Exp. Med. 211, 2013-2032 (2014).
236. Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M. Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M. and Takeda K: Generation of colonic IgA-secreting cells in the cecal patch. Nat. Commun. 5, 3704 (2014).
235. Meunier, E., Dick, M., Dreier, R., Broz, D. K., Yamamoto, M., Takeda K, Schurmann, N., Bumann, D., Warming, S., Roose-Girma, M., Kayagaki, N., Broz, P.: Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature 509, 366-370 (2014).
234. Ohshima, J., Lee, Y., Sasai, M., Saitoh, T., Ma, J.S., Kamiyama, N., Matsuura, Y., Pann-Ghill, S., Hayashi, M., Ebisu, S., Takeda K, Akira, S., and Yamamoto, M.: Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii. J. Immunol. 192, 3328-3335 (2014).
233. Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Trobauh D. W., Huang, C., Szretter, K. J., Paessler, S., Takeda K, Amarasinghe, G., Klimstra, W. B. and Diamond, M. S.: A viral RNA structural element alters host recognition of non-self RNA.
Science 343, 783-787 (2014).
232. Yokota, K., Sato, K., Miyazaki, T., Kitaura, H., Kayama, H., Miyoshi, F., Akiyama, Y., Takeda K, and Mimura, T.: Combination of tumor necrosis factor ? and interleukin 6 induces both in vitro and in vivo osteoclast-like cells with bone-resorption activity.
Arthritis Rheum. 66, 121-129 (2014).
2013
231. Shimada, Y., Kinoshita, M., Harada, K., Mizutani, M., Masahata, K., Kayama, H. and Takeda K: Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon. PLoS One 8(11): e80604 (2013).
230. Ogino, T., Nishimura, J., Barman, S., Kayama, H., Uematsu, S., Haraguchi, N., Uemura, M., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Takeda K, Doki, Y., and Mori, M.: Increased Th17-inducing activity of CD14(+) CD163(low) myeloid cells in intestinal lamina propria of patients with Crohn's disease. Gastroenterol. 145, 1380-1391 (2013).
229. Kimura, T., Katoh, H., Kayama, H., Saiga, H., Okuyama, M., Okamoto, T., Umemoto, E., Matsuura, Y., Yamamoto, M. and Takeda K: Ifit1 inhibits JEV replication through binding to 5' capped 2'-O unmethylated RNA. J. Virol. 87, 9997-10003 (2013).
228. Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda K, Naka, T., and Yamashita, T.: Ifn-g-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 4, e710 (2013).
227. Kunisawa, J., Gohda, M., Hashimoto, E., Ishikawa, I., Higuchi, M., Suzuki, Y., Goto, Y., Panea, C., Ivanov, I. I., Sumiya, R., Aayam, L., Wake, T., Tajiri, S., Kurashima, Y., Shikata, S., Akira, S., Takeda K, and Kiyono, H.: Microbe-dependent CD11b+ IgA+ plasma cells in early-phase robustintestinal IgA responses in mice. Nat. Commun. 23,1772 (2013).
226. Kamiyama, N., Yamamoto, M., Saiga, H., Ma, J.S., Ohshima, J., Machimura, S., Sasai, M., Kimura, T., Ueda, Y., Kayama, H., and Takeda K: CREBH determines the severity of sulpyrine-induced fatal shock. PLoS One. 8, e55800 (2013).
225. Kusu, T., Kayama, H., Kinoshita, M., Jeon, S.G., Ueda, Y., Goto, Y., Okumura, R., Saiga, H., Kurakawa, T., Ikeda, K., Maeda, Y., Nishimura, J., Arima, Y., Atarashi, K., Honda, K., Murakami, M., Kunisawa, J., Kiyono, H., Okumura, M., Yamamoto, M., and Takeda K: ENTPDase7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J. Immunol. 190, 774-783 (2013).
2012
224. Shigekawa, M., Hikita, H., Kodama, T., Shimizu, S., Li, W., Uemura, A., Miyagi, T., Hosui, A., Kanto, T., Hiramatsu, N., Tatsumi, T., Takeda K, Akira, S., and Takehara, T.: Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction. Am. J. Pathol. 181, 2105-2113 (2012).
223. Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M. and Takeda K: Critical role of AIM2 in Mycobacterium tuberculosis infection. Int. Immunol. 24, 637-644 (2012).
222. Kinoshita, M., Kayama, H., Kusu, T., Yamaguchi, T., Kunisawa, J., Kiyono, H., Sakaguchi, S. and Takeda K: Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J. Immunol. 189, 2869-2878 (2012).
221. Yamamoto, M., Okuyama, M., Ma, J. S., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Kayama, H., Okamoto, T., Huang, D. C. S., Soldati-Farve, D., Horie, K., Takeda, J. and Takeda K: A cluster of IFN-g-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity 37, 302-313 (2012).
220. Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K. and Takeda K: Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathogens 8, e1002714 (2012).
219. Kayama, H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S., Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H. and Takeda K: Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109, 5010-5015 (2012).
218. Niida, T., Isoda, K., Kitagaki, M., Ishigami, N., Adachi, T., Matsubara, O., Takeda K, Kishimoto, T. and Ohsuzu, F.: IkBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice. Cardiovas. Res. 93, 371-379 (2012).
2011
217. Takata, K., Kinoshita, M., Okuno, T., Moriya, M., Kohda, T. Honorat. J.A., Sugimoto, T., Kumanogoh, A., Kayama, H., Takeda K, Sakoda, S. and Nakatsuji, Y.: The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T Cells. PLoS One 6, e27644, (2011).
216. Matsuda, A., Ogawa, M., Yanai, H., Naka, D., Goto, A., Ao, T., Tanno, Y., Takeda K, Watanabe, Y., Honda, K., and Taniguchi, T.: Generation of mice deficient in RNA-binding motif protein 3 and characterization of its role in innate immune responses and cell growth. Biochem. Biophys. Res. Commun. 411, 7-13 (2011).
215. Yamamoto, M., Ma, J. S., Mueller, C., Kamiyama, N., Saiga, H., Kubo, E., Kimura, T., Okamoto, T., Okuyama, M., Kayama, H., Nagamune, K., Takashima, S., Soldati-Favre, D., Matsuura, Y., Takeda K: ATF6? is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J. Exp. Med. 208, 1533-1546 (2011).
214. Iwata-Kajihara, T., Sumimoto, H., Kawamura, N., Ueda, R., Takahashi, T., Mizuguchi, H., Miyagishi, M., Takeda K and Kawakami, Y.: Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol. 187, 27-36 (2011).
213. Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda K, Hori, S., Ivanov, I.I., Umesaki, Y., Itoh, K., and Honda, K.: Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337-341 (2011).
2010
212. Ueda, Y., Kayama, H., Jeon, S.-G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M. and Takeda K: Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int. Immunol. 22, 953-962 (2010).
211. Xiao, G., Miyazato, A., Abe, Y., Zhang, T., Nakamura, K., Inden, K., Tanaka, M., Tanno, D., Miyasaka, T., Ishii, K., Takeda K, Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Yamamoto, N., Kunishima, H., Hirakata, Y., Kaku, M., and Kawakami, K.: Activation of myeloid dendritic cells by deoxynucleic acids from Cordyceps sinensis via a Toll-like receptor 9-dependent pathway. Cell Immunol. 263, 241-250 (2010).
210. Okuyama, M., Kayama, H., Atarashi, K., Saiga, H., Kimura, T., Waisman, A., Yamamoto, M., and Takeda K: A novel inducible dendritic cell ablation model in mice. Biochem. Biophys. Res. Commun. 397, 559-563 (2010).
209. Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda K, Matsumiya, G., Azuma, J. and Fujio, Y.: Therapeutic activation of STAT3 by Interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121, 684-691 (2010).
2009
208. Yamamoto, M., Standley, D.M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., Soldati-Farve, D., and Takeda K: A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J. Exp.Med. 206, 2747-2760 (2009).
207. Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., Tanoue, T., Imaoka, A., Itoh, K., Takeda K, Umesaki, Y., Honda, K., Littman, D. R.:Induction of Intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
206. Pejnovic, N., Vratimos, A., Lee, S. H., Popadic, D., Takeda K, Akira, S., and Chan, W. L.: Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet. Mol Immunol. 47, 37-45 (2009).
205. Miyazato, A., Nakamura, K., Yamamoto, N., Mora-Montes, H. N., Tanaka, M., Abe, Y., Tannno, D., Inden, K., Gang, X., Ishii, K., Takeda K, Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Mitsutake, K., Gowm N. A. R., Kaku, M., and Kawakami, K.: Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans. Infect. Immun. 77, 3056-3064 (2009).
204. Kayama, H., Koga, R., Atarashi, K., Mak, T. W., Takayanagi, H., Honda, K., Yamamoto, M. and Takeda K: NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathogens 5, e1000514 (2009).
203. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Takeno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda K, Akira, S., and Saito, T.: C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA. 106, 1897-902 (2009).
202. Morishita, H., Saito, F., Kayama, H., Atarashi, K., Kuwata, H., Yamamoto, M., and Takeda K: Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. Int. Immunol. 21, 457-465 (2009).
201. Haga, S., Ozaki, M., Inoue, H., Okamoto, Y., Ogawa, W., Takeda K, Akira, S., and Todo, S.: The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49, 204-214 (2009).
2008
200. Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M. and Takeda K: Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J. Immunol. 181, 8521-8527 (2008).
199. Nakamura, K., Miyazato, A., Koguchi, Y., Adachi, Y., Ohno, N., Saijo, S., Iwakura, Y., Takeda K, Akira, S., Fujita, J., Ishii, K., Kaku, M., and Kawakami, K.: Toll-like receptor (TLR) 2 and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei. Microbes Infect. 10, 1223-1227 (2008).
198. Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., and Takeda K: ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).
197. Nakamura, J., Fujimoto, M., Yasuda, K., Takeda K, Akira, S., Hatayama, T., Takagi, Y., Nozaki, K., Hosokawa, N., and Nagata, K.: Targeted disruption of Hsp110/105 gene protects against ischemic stress. Stroke 9, 2853-2859 (2008).
196. Saito, F., Kuwata, H., Oike, E., Koike, M., Uchiyama, Y., Honda, K., and Takeda K: Inefficient phagosome maturation in infant macrophages. Biochem. Biophys. Res. Commun. 375, 113-118 (2008).
195. Herrmann, J., Imura, T., Song, B., Ao, Y., Qi, J., Nguyen, T., Korsak, R., Takeda K, Akira, S., and Sofroniew, M.: STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J. Neurosci. 28, 7231-7243 (2008).
194. Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda K, Akira, S., Low, M. J., Rubinstein, M., and Mackenzie, R. G.: Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis. Endocrinology 149, 3346-3354 (2008).
193. Ueta, M., Hamuro, J., Ueda, E., Katoh, N., Yamamoto, M., Takeda K, Akira, S., and Kinoshita, S.: Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of I?B?-/- mice. Invest. Ophthalmol. Vis. Sci. 49, 3387-3394 (2008).
192. Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., and Takeda K: Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkB?. J. Biol. Chem. 283, 12468-12477 (2008).
191. Nakamura, K., Miyazato, A., Gang, X., Hatta, M., Inden, K., Aoyagi, T., Takeda K, Akira, S., Saijo, S., Iwakura, Y., Adachi, Y., Ohno, N., Suzuki, K., Fujita, J., Kaku, M., and Kawakami, K: Deoxynucleic acids fromCryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependentpathway. J. Immunol. 180, 4067-4074 (2008).
190. Nishimura, J., Saiga, H., Sato, S., Okuyama, M., Kayama, H., Kuwata, H., Matsumoto, S., Nishida, T., Sawa, Y., Akira, S., Yoshikai, Y., Yamamoto, M., and Takeda K: Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor. J. Immunol. 180, 4032-4039 (2008).
189. Hisaeda, H., Tetsutani, K., Imai, T., Moriya, C., Tu, L., Hamano, S., Duan, X., Chou, B., Ishida, H., Aramaki, A., Shen, J., Ishii, K., J., Coban, C., Akira, S. Takeda K, Yasutomo, K., Torii, M., and Himeno, K.: Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J. Immunol. 180, 2496-2503 (2008).
188. Owaki, T., Asakawa, M., Morishima, N., Mizoguchi, I., Fukai, F., Takeda K, Mizuguchi, J. and Yoshimoto, T.: STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J. Immunol. 180, 2903-2911 (2008).
2007
187. Yamamoto, M., Uematsu, S., Okamoto, T., Matsuura, Y., Sato, S., Kumar, H., Satoh, T., Saitoh, T., Takeda K, Ishii, K. J., Takeuchi, O., Kawai, T., and Akira, S.: Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J. Exp. Med. 204, 2233-2239 (2007).
186. Sakamori, R., Takehara, T., Ohnishi, C., Tatsumi, T., Ohkawa, K., Takeda K, Akira, S., Hayashi, N.: STAT3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 46, 1564-1573 (2007).
185. Nemoto,Y., Kanai, T., Makita, S., Okamoto, R., Totsuka, T., Takeda K and Watanabe, M.: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastoroenterology 132, 176-189 (2007).
