研究業績
2026
- Suzuki D, Yang J, Obana N, Yachida S, Shiba S, Mizutani S, Takamaru H, Saito Y, Fukuda S, Yamada T. Clinical strains isolated from early-stage colorectal cancer patients promote tumorigenesis. PeerJ. 2026 Jul 14;14:e21488. doi: 10.7717/peerj.21488. eCollection 2026. PMID: 42491728
- Fukagawa A, Arai Y, Maeshima A, Hama N, Totoki Y, Nakamura H, Saito-Adachi M, Hokazono Y, Nakamura E, Matsui Y, Adachi S, Hamamoto R, Ushiku T, Yachida S, Shibata T. Proteomic Analysis Identifies Potential Biomarkers of ELOC-Mutated Renal Cell Carcinoma. Am J Surg Pathol. 2026 Jul 13. doi: 10.1097/PAS.0000000000002583. Online ahead of print. PMID: 42438270
- Yasuda S, Oya K, Ikuta S, Takata S, Nakatani Y, Totoki Y, Uzawa N, Yachida S. Clinicopathological and genetic analysis of primary intraosseous carcinoma not otherwise specified (PIOC NOS). BMC Oral Health. 2026 Jun 29. doi: 10.1186/s12903-026-09040-9. Online ahead of print. PMID: 42374478
- Kuchiba A, Nishino J, Yachida S, Sunami K, Koyama T, Yamamoto N, Kato M, Shibata T. Performance of the permutation test approach with base calling errors for detecting changes in variant allele frequencies in ctDNA for a single patient. Stat Appl Genet Mol Biol. 2026 May 20;25(1). doi: 10.1515/sagmb-2024-0020. eCollection 2026 Jan 1. PMID: 42155062
- Takata S, Horie M, Miyabe K, Ito Y, Nakatani Y, Kudo-Asabe Y, Ishida H, Yamada S, Goto A, Kumanogoh A, Shintani Y, Morii E, Yachida S, Maeda D. Thymic cyst: A clinicopathological, immunohistochemical, and molecular study of 36 cases focusing on squamous- and ciliated-type epithelium. Hum Pathol. 2026 Mar 16;172:106109. doi: 10.1016/j.humpath.2026.106109. Online ahead of print. PMID: 41850630
- Hokazono Y, Saito-Adachi M, Hama N, Totoki Y, Nakamura H, Arai Y, Yachida S, Fukagawa A, Rokutan H, Ushiku T, Shibata T. Clinicopathological and genomic features of extrachromosomal DNA in gastric cancer. Gastric Cancer. 2026 Jan;29(1):27-38. doi: 10.1007/s10120-025-01666-y. Epub 2025 Oct 18. PMID: 41107687
2025
- Kashiwagi T, Takata S, Tanaka H, Ikuta S, Totoki Y, Nakatani Y, Inohara H, Uzawa N, Yachida S. Variation of Gene Expression and Methylation Profiling in Gingival and Tongue Cancers. Cancer Sci. 2025 Dec;116(12):3459-3472. doi: 10.1111/cas.70205. Epub 2025 Sep 28. PMID: 41016725
- Zha L, Shimomura Y, Kitamura T, Komukai S, Narii N, Komatsu M, Shiba S, Mizutani S, Yamada T, Yachida S, Sobue T. Different impacts of intestinal microbiota and lifestyle factors on advanced adenoma and colorectal cancer risk. Eur J Cancer Prev. 2026 May 1;35(3):250-257. doi: 10.1097/CEJ.0000000000000974. Epub 2025 May 27. PMID: 40454466
- Ishida H, Takata S, Aya K, Nakatani Y, Horie M, Maeda D, Funaki S, Shintani Y, Yachida S. Characterizing the tumor immune environment in thymic epithelial tumors using T-cell receptor repertoire analysis and gene expression profiling. JTCVS Open. 2025 Mar 20;25:435-465. doi: 10.1016/j.xjon.2025.03.008. eCollection 2025 Jun. PMID: 40631010
- Kato S, Miyoshi N, Fujino S, Horie M, Yachida S, Takeda M, Sekido Y, Hata T, Hamabe A, Ogino T, Uemura M, Yamamoto H, Yasui M, Ohue M, Doki Y, Eguchi H. Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell Growth. Ann Surg Oncol. 2025 Oct;32(10):7333-7343. doi: 10.1245/s10434-025-17765-0. Epub 2025 Jul 31. PMID: 40745121
- Yachida S, Yoshinaga S, Shiba S, Urabe M, Tanaka H, Takeda Y, Shimizu A, Sakamoto Y, Hijioka S, Haba S, Ashida R, Kushiyama Y, Asano K, Kobayashi M, Murawaki Y, Onishi K, Yamashita T, Kimura H, Totoki Y, Kamada H, Isomoto H, Hattori S, Morizane C, Ohkawa K, Kitano M, Hara K, Ikezawa K, Hanada K, Matsumoto K. KRAS Mutations in Duodenal Lavage Fluid after Secretin Stimulation for Detection of Pancreatic Cancer. Ann Surg. 2025 Feb 4. doi: 10.1097/SLA.0000000000006645. Online ahead of print. PMID: 39902566
- Takamaru H, Tsay C, Shiba S, Yachida S, Saito Y. Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies. J Anus Rectum Colon. 2025 Jan 25;9(1):20-24. doi: 10.23922/jarc.2024-080. eCollection 2025. PMID: 39882224
- Mizutani S, Tamaki A, Shiba S, Salim F, Yamada M, Takamaru H, Nakajima T, Yoshida N, Ikuta S, Yachida T, Shibata T, Soga T, Saito Y, Fukuda S, Ishikawa H, Yamada T, Yachida S. Dynamics of the gut microbiome in FAP patients undergoing intensive endoscopic reduction of polyp burden. Gut. 2025 Jan 17;74(2):335-338. doi: 10.1136/gutjnl-2024-332381. PMID: 39089862
2024
- Ikuta S, Saito Y, Takata S, Nakatani Y, Nagatomo I, Shiba S, Takeda Y, Totoki Y, Mizutani S, Sunakawa H, Ikematsu H, Takamaru H, Kumanogoh A, Yachida S. Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies. Mol Cancer. 2024 Nov 7;23(1):249. doi: 10.1186/s12943-024-02159-9. PMID: 39511621
- Salim F, Mizutani S, Shiba S, Takamaru H, Yamada M, Nakajima T, Yachida T, Soga T, Saito Y, Fukuda S, Yachida S, Yamada T. Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer. iScience. 2024 Jun 4;27(7):110181. doi: 10.1016/j.isci.2024.110181. eCollection 2024 Jul 19. PMID: 38993678
- Eguchi H, Takenaka Y, Tanaka H, Suzuki M, Horie M, Kanai H, Seo Y, Ogawa K, Yachida S, Inohara H. Survival of Metastatic Human Papillomavirus (HPV)-Related Head and Neck Cancer Receiving Platinum-Based Triplet Induction Chemotherapy and Relevance of Circulating Tumor HPV DNA. Cureus. 2024 May 18;16(5):e60547. doi: 10.7759/cureus.60547. eCollection 2024 May. PMID: 38887331
- Cubiella T, Celada L, San-Juan-Guardado J, Rodríguez-Aguilar R, Suárez-Priede Á, Poch M, Dominguez F, Fernández-Vega I, Montero-Pavón P, Fraga MF, Nakatani Y, Takata S, Yachida S, Valdés N, Chiara MD. PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas. J Pathol. 2024 Aug;263(4-5):418-428. doi: 10.1002/path.6291. Epub 2024 May 25. PMID: 38795318
- Narii N, Zha L, Sobue T, Kitamura T, Komatsu M, Shimomura Y, Shiba S, Mizutani S, Yamada T, Yachida S. Intestinal Bacteria Fluctuating in Early-Stage Colorectal Cancer Carcinogenesis are Associated with Diet in Healthy Adults. Nutr Cancer. 2024;76(6):521-528. doi: 10.1080/01635581.2024.2344257. Epub 2024 Apr 20. PMID: 38642022
- Rokutan H, Arai Y, Kunita A, Yamasaki S, Nakamura H, Hama N, Nakayama A, Hosoda F, Totoki Y, Fujishiro M, Seto Y, Shibata T, Ushiku T. Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation. Am J Surg Pathol. 2024 Jun 1;48(6):652-661. doi: 10.1097/PAS.0000000000002222. Epub 2024 Apr 8. PMID: 38584451
- Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA. DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms. Clin Gastroenterol Hepatol. 2024 Jun;22(6):1245-1254.e10. doi: 10.1016/j.cgh.2024.02.007. Epub 2024 Feb 20. PMID: 38382726
- Tatsumi M, Tanaka H, Takenaka Y, Suzuki M, Fukusumi T, Eguchi H, Watabe T, Kato H, Yachida S, Inohara H, Tomiyama N. Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma. Sci Rep. 2024 Feb 8;14(1):3278. doi: 10.1038/s41598-024-53894-4. PMID: 38332246
- Kage H, Akiyama N, Chang H, Shinozaki-Ushiku A, Ka M, Kawata J, Muto M, Okuma Y, Okita N, Tsuchihara K, Kikuchi J, Shirota H, Hayashi H, Kokuryo T, Yachida S, Hirasawa A, Kubo M, Kenmotsu H, Tanabe M, Ushiku T, Muto K, Seto Y, Oda K. Patient survey on cancer genomic medicine in Japan under the national health insurance system. Cancer Sci. 2024 Mar;115(3):954-962. doi: 10.1111/cas.16065. Epub 2024 Jan 26. PMID: 38273803
2023
- Fukagawa A, Hama N, Totoki Y, Nakamura H, Arai Y, Saito-Adachi M, Maeshima A, Matsui Y, Yachida S, Ushiku T, Shibata T. Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort. Nat Commun. 2023 Dec 16;14(1):8383. doi: 10.1038/s41467-023-44159-1. PMID: 38104198
- Fujino S, Miyoshi N, Ito A, Hayashi R, Yasui M, Matsuda C, Ohue M, Horie M, Yachida S, Koseki J, Shimamura T, Hata T, Ogino T, Takahashi H, Uemura M, Mizushima T, Doki Y, Eguchi H. Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer. Commun Biol. 2023 Nov 24;6(1):1191. doi: 10.1038/s42003-023-05562-y. PMID: 37996567
- Nagae A, Miyoshi N, Fujino S, Horie M, Yachida S, Sasaki M, Sekido Y, Hata T, Hamabe A, Ogino T, Takahashi H, Uemura M, Yamamoto H, Doki Y, Eguchi H. Cancer Stem Cells Persist Despite Cellular Damage, Emergence of the Refractory Cell Population. Ann Surg Oncol. 2023 Oct;30(11):6913-6924. doi: 10.1245/s10434-023-13849-x. Epub 2023 Jul 31. PMID: 37523119
- Saito-Adachi M, Hama N, Totoki Y, Nakamura H, Arai Y, Hosoda F, Rokutan H, Yachida S, Kato M, Fukagawa A, Shibata T. Oncogenic structural aberration landscape in gastric cancer genomes. Nat Commun. 2023 Jun 22;14(1):3688. doi: 10.1038/s41467-023-39263-1. PMID: 37349325
- Totoki Y, Saito-Adachi M, Shiraishi Y, Komura D, Nakamura H, Suzuki A, Tatsuno K, Rokutan H, Hama N, Yamamoto S, Ono H, Arai Y, Hosoda F, Katoh H, Chiba K, Iida N, Nagae G, Ueda H, Shihang C, Sekine S, Abe H, Nomura S, Matsuura T, Sakai E, Ohshima T, Rino Y, Yeoh KG, So J, Sanghvi K, Soong R, Fukagawa A, Yachida S, Kato M, Seto Y, Ushiku T, Nakajima A, Katai H, Tan P, Ishikawa S, Aburatani H, Shibata T. Multiancestry genomic and transcriptomic analysis of gastric cancer. Nat Genet. 2023 Apr;55(4):581-594. doi: 10.1038/s41588-023-01333-x. Epub 2023 Mar 13. PMID: 36914835
- Tabata S, Kojima Y, Sakamoto T, Igarashi K, Umetsu K, Ishikawa T, Hirayama A, Kajino-Sakamoto R, Sakamoto N, Yasumoto KI, Okano K, Suzuki Y, Yachida S, Aoki M, Soga T. L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis. Oncogene. 2023 Apr;42(16):1294-1307. doi: 10.1038/s41388-023-02632-7. Epub 2023 Mar 6. PMID: 36879117
- Horie M, Tanaka H, Suzuki M, Sato Y, Takata S, Takai E, Miyashita N, Saito A, Nakatani Y, Yachida S. An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1-positive neuroendocrine carcinoma. Cancer Sci. 2023 Jun;114(6):2596-2608. doi: 10.1111/cas.15764. Epub 2023 Mar 15. PMID: 36840413
- Tanaka J, Nakagawa T, Harada K, Morizane C, Tanaka H, Shiba S, Ohba A, Hijioka S, Takai E, Yachida S, Kamura Y, Ishida T, Yokoi T, Uematsu C. Efficient and accurate KRAS genotyping using digital PCR combined with melting curve analysis for ctDNA from pancreatic cancer patients. Sci Rep. 2023 Feb 21;13(1):3039. doi: 10.1038/s41598-023-30131-y. PMID: 36810451
- Tanaka H, Uno A, Takenaka Y, Suzuki M, Seo Y, Takemoto N, Fukusumi T, Eguchi H, Kanai H, Horie M, Isohashi F, Ogawa K, Yachida S, Inohara H. Clearance Profile of Circulating Tumor Human Papillomavirus DNA During Radiotherapy Predicts Clinical Outcomes in Human Papillomavirus-Related Oropharyngeal Cancer. JCO Precis Oncol. 2023 Feb;7:e2200494. doi: 10.1200/PO.22.00494. PMID: 36787504
- Rynazal R, Fujisawa K, Shiroma H, Salim F, Mizutani S, Shiba S, Yachida S, Yamada T. Leveraging explainable AI for gut microbiome-based colorectal cancer classification. Genome Biol. 2023 Feb 9;24(1):21. doi: 10.1186/s13059-023-02858-4. PMID: 36759888
- Narii N, Zha L, Sobue T, Kitamura T, Shiba S, Mizutani S, Yamada T, Yachida S. Association Between Diet and Fusobacterium nucleatum in the Feces of Healthy Adults: A Hospital-based Cross-sectional Study. Cancer Prev Res (Phila). 2023 Jan 30:OF1-OF8. doi: 10.1158/1940-6207.CAPR-22-0399. Online ahead of print. PMID: 36719965
- Shimomura Y, Zha L, Komukai S, Narii N, Sobue T, Kitamura T, Shiba S, Mizutani S, Yamada T, Sawada N, Yachida S. Mediation effect of intestinal microbiota on the relationship between fiber intake and colorectal cancer. Int J Cancer. 2023 May 1;152(9):1752-1762. doi: 10.1002/ijc.34398. Epub 2022 Dec 21. PMID: 36522829
2022
- Narii N, Zha L, Sobue T, Kitamura T, Shiba S, Mizutani S, Yamada T, Yachida S. Association between Diet and Fusobacterium nucleatum in the Feces of Healthy Adults: A hospital-based cross-sectional study. Cancer Prev Res (Phila). 2022 Dec 6:CAPR-22-0399. doi: 10.1158/1940-6207.CAPR-22-0399. Online ahead of print. PMID: 36474311
- Takata S, Miyake K, Maeda D, Hatake K, Nagatomo I, Shiroyama T, Masuhiro K, Yaga M, Shirai Y, Mitsui Y, Yachida S, Kumanogoh A. Proposal of a novel pipeline involving precise bronchoscopy of distal peripheral pulmonary lesions for genetic testing. Sci Rep. 2022 Nov 17;12(1):19774. doi: 10.1038/s41598-022-24372-6. PMID: 36396864
- Terashima T, Morizane C, Ushiama M, Shiba S, Takahashi H, Ikeda M, Mizuno N, Tsuji K, Yasui K, Azemoto N, Satake H, Nomura S, Yachida S, Sugano K, Furuse J. Germline variants in cancer-predisposing genes in pancreatic cancer patients with a family history of cancer. Jpn J Clin Oncol. 2022 Oct 6;52(10):1105-1114. doi: 10.1093/jjco/hyac110. PMID: 36135357
- Ishioka C, Muto M, Yachida S, Shirota H, Hirasawa A, Miyagawa K, Ashizawa K, Kinoshita I, Nishihara H, Matsuura N, Sakurai A.[Panel Discussion - Problems in the Cancer Genomic Medicine]. Gan To Kagaku Ryoho. 2022 Sep;49(9):1014-1017. PMID: 36156030
- Yachida S.[Challenges in Expert Panel]. Gan To Kagaku Ryoho. 2022 Sep;49(9):994-996. PMID: 36156023
- Oba U, Kohashi K, Sangatsuda Y, Oda Y, Sonoda KH, Ohga S, Yoshimoto K, Arai Y, Yachida S, Shibata T, Ito T, Miura F. An efficient procedure for the recovery of DNA from formalin-fixed paraffin-embedded tissue sections. Biol Methods Protoc. 2022 Jul 26;7(1):bpac014. doi: 10.1093/biomethods/bpac014. eCollection 2022. PMID: 35937639
- Inamura K, Hamada T, Bullman S, Ugai T, Yachida S, Ogino S. Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science. Gut. 2022 Jul 12:gutjnl-2022-327209. doi: 10.1136/gutjnl-2022-327209. Online ahead of print. PMID: 35820782
- Shiroma H, Shiba S, Erawijantari PP, Takamaru H, Yamada M, Sakamoto T, Kanemitsu Y, Mizutani S, Soga T, Saito Y, Shibata T, Fukuda S, Yachida S, Yamada T. Surgical Treatment for Colorectal Cancer Partially Restores Gut Microbiome and Metabolome Traits. mSystems. 2022 Apr 26;7(2):e0001822. doi: 10.1128/msystems.00018-22. Epub 2022 Mar 21. PMID: 35311577
- Matsushita M, Fujita K, Motooka D, Hatano K, Hata J, Nishimoto M, Banno E, Takezawa K, Fukuhara S, Kiuchi H, Pan Y, Takao T, Tsujimura A, Yachida S, Nakamura S, Obara W, Uemura H, Nonomura N. Firmicutes in Gut Microbiota Correlate with Blood Testosterone Levels in Elderly Men. World J Mens Health. 2022 Jul;40(3):517-525. doi: 10.5534/wjmh.210190. Epub 2022 Feb 24. PMID: 35274505
- Yachida S, Totoki Y, Noë M, Nakatani Y, Horie M, Kawasaki K, Nakamura H, Saito-Adachi M, Suzuki M, Takai E, Hama N, Higuchi R, Hirono S, Shiba S, Kato M, Furukawa E, Arai Y, Rokutan H, Hashimoto T, Mitsunaga S, Kanda M, Tanaka H, Takata S, Shimomura A, Oshima M, Hackeng WM, Okumura T, Okano K, Yamamoto M, Yamaue H, Morizane C, Arihiro K, Furukawa T, Sato T, Kiyono T, Brosens LAA, Wood LD, Hruban RH, Shibata T. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System. Cancer Discov. 2022 Mar 1;12(3):692-711. doi: 10.1158/2159-8290.CD-21-0669. PMID: 34880079
- Tanaka H, Suzuki M, Takemoto N, Fukusumi T, Eguchi H, Takai E, Kanai H, Tatsumi M, Horie M, Takenaka Y, Yachida S, Inohara H. Performance of oral HPV DNA, oral HPV mRNA and circulating tumor HPV DNA in the detection of HPV-related oropharyngeal cancer and cancer of unknown primary. Int J Cancer. 2022 Jan 1;150(1):174-186. doi: 10.1002/ijc.33798. Epub 2021 Sep 20. PMID: 34486724
- Takai E, Nakamura H, Chiku S, Kubo E, Ohmoto A, Totoki Y, Shibata T, Higuchi R, Yamamoto M, Furuse J, Shimizu K, Takahashi H, Morizane C, Furukawa T, Yachida S. Whole-exome Sequencing Reveals New Potential Susceptibility Genes for Japanese Familial Pancreatic Cancer. Ann Surg. 2022 Apr 1;275(4):e652-e658. doi: 10.1097/SLA.0000000000004213. PMID: 32826389
- Suzuki H, Mitsunaga S, Ikeda M, Aoyama T, Yoshizawa K, Yamaguchi M, Suzuki M, Narita M, Kawasaki T, Ochiai A. Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer. Cancer Med. 2022 Dec;11(24):5001-5012. doi: 10.1002/cam4.4823. Epub 2022 May 16. PMID: 35578571
2021
- Nakamura R, Motai Y, Kumagai M, Wike CL, Nishiyama H, Nakatani Y, Durand NC, Kondo K, Kondo T, Tsukahara T, Shimada A, Cairns BR, Aiden EL, Morishita S, Takeda H.CTCF looping is established during gastrulation in medaka embryos. Genome Res. 2021 Jun;31(6):968-980. doi: 10.1101/gr.269951.120. Epub 2021 May 18. PMID: 34006570
- Takai E, Omata W, Totoki Y, Nakamura H, Shiba S, Takahashi A, Namikawa K, Mori T, Yamazaki N, Shibata T, Yachida S. Clonal dynamics of circulating tumor DNA during immune checkpoint blockade therapy for melanoma. Cancer Sci. 2021 Nov;112(11):4748-4757. doi: 10.1111/cas.15088. Epub 2021 Sep 22. PMID: 34477284
- Miyashita N, Enokido T, Horie M, Fukuda K, Urushiyama H, Strell C, Brunnström H, Micke P, Saito A, Nagase T. TGF-β-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma. Sci Rep. 2021 Nov 17;11(1):22380. doi: 10.1038/s41598-021-01799-x. PMID: 34789779
- Yamaguchi Y, Saito A, Horie M, Aoki A, Micke P, Ohshima M, Kappert K. Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis. Odontology. 2021 Oct;109(4):912-920. doi: 10.1007/s10266-021-00625-0. Epub 2021 Jun 14. PMID: 34128105
- Matsushita M, Fujita K, Motooka D, Hatano K, Fukae S, Kawamura N, Tomiyama E, Hayashi Y, Banno E, Takao T, Takada S, Yachida S, Uemura H, Nakamura S, Nonomura N. The gut microbiota associated with high-Gleason prostate cancer. Cancer Sci. 2021 Aug;112(8):3125-3135. doi: 10.1111/cas.14998. Epub 2021 Jul 5. PMID: 34051009
- Grapotte M, Saraswat M, Bessière C, Menichelli C, Ramilowski JA, Severin J, Hayashizaki Y, Itoh M, Tagami M, Murata M, Kojima-Ishiyama M, Noma S, Noguchi S, Kasukawa T, Hasegawa A, Suzuki H, Nishiyori-Sueki H, Frith MC; FANTOM consortium; Chatelain C, Carninci P, de Hoon MJL, Wasserman WW, Bréhélin L, Lecellier CH. Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nat Commun. 2021 Jun 2;12(1):3297. doi: 10.1038/s41467-021-23143-7. PMID: 34078885
- Inagaki C, Maeda D, Hatake K, Sato Y, Hashimoto K, Sakai D, Yachida S, Nonomura N, Satoh T. Clinical Utility of Next-Generation Sequencing-Based Panel Testing under the Universal Health-Care System in Japan: A Retrospective Analysis at a Single University Hospital. Cancers (Basel). 2021 Mar 5;13(5):1121. doi: 10.3390/cancers13051121. PMID: 33807840
- Suzuki M, Saito-Adachi M, Arai Y, Fujiwara Y, Takai E, Shibata S, Seki M, Rokutan H, Maeda D, Horie M, Suzuki Y, Shibata T, Kiyono T, Yachida S. E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer. Cancer Res. 2021 Jan 15;81(2):489-500. doi: 10.1158/0008-5472.CAN-19-2988. Epub 2020 Dec 8. PMID: 33293429
- Naito Y, Aburatani H, Amano T, Baba E, Furukawa T, Hayashida T, Hiyama E, Ikeda S, Kanai M, Kato M, Kinoshita I, Kiyota N, Kohno T, Kohsaka S, Komine K, Matsumura I, Miura Y, Nakamura Y, Natsume A, Nishio K, Oda K, Oda N, Okita N, Oseto K, Sunami K, Takahashi H, Takeda M, Tashiro S, Toyooka S, Ueno H, Yachida S, Yoshino T, Tsuchihara K;Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1). Japanese Society of Medical Oncology; Japan Society of Clinical Oncology; Japanese Cancer Association. Int J Clin Oncol. 2021 Feb;26(2):233-283. doi: 10.1007/s10147-020-01831-6. Epub 2020 Nov 29. PMID: 33249514
- Tanaka H, Takemoto N, Horie M, Takai E, Fukusumi T, Suzuki M, Eguchi H, Komukai S, Tatsumi M, Isohashi F, Ogawa K, Yachida S, Inohara H. Circulating tumor HPV DNA complements PET-CT in guiding management after radiotherapy in HPV-related squamous cell carcinoma of the head and neck. Int J Cancer. 2021 Feb 15;148(4):995-1005. doi: 10.1002/ijc.33287. Epub 2020 Sep 30. PMID: 32895945
2020
- Shibayama Y, Takahashi K, Yamaguchi H, Yasuda J, Yamazaki D, Rahman A, Fujimori T, Fujisawa Y, Takai S, Furukawa T, Nakagawa T, Ohsaki H, Kobara H, Wong JH, Masaki T, Yuzawa Y, Kiyomoto H, Yachida S, Fujimoto A, Nishiyama A. Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H. Commun Biol. 2020 Nov 27;3(1):724. doi: 10.1038/s42003-020-01434-x. PMID: 33247206
- Nomura Y, Tamura D, Horie M, Sato M, Sasaki S, Yamamoto Y, Kudo-Asabe Y, Umakoshi M, Koyama K, Makino K, Takashima S, Imai K, Minamiya Y, Munakata S, Yachida S, Terada Y, Goto A, Maeda D. Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule. Genes Chromosomes Cancer. 2020 Aug 20. doi: 10.1002/gcc.22892. Online ahead of print. PMID: 32820570
- Noë M, Niknafs N, Fischer CG, Hackeng WM, Beleva Guthrie V, Hosoda W, Debeljak M, Papp E, Adleff V, White JR, Luchini C, Pea A, Scarpa A, Butturini G, Zamboni G, Castelli P, Hong SM, Yachida S, Hiraoka N, Gill AJ, Samra JS, Offerhaus GJA, Hoorens A, Verheij J, Jansen C, Adsay NV, Jiang W, Winter J, Albores-Saavedra J, Terris B, Thompson ED, Roberts NJ, Hruban RH, Karchin R, Scharpf RB, Brosens LAA, Velculescu VE, Wood LD. Genomic characterization of malignant progression in neoplastic pancreatic cysts. Nat Commun. 2020 Aug 14;11(1):4085. doi: 10.1038/s41467-020-17917-8. PMID: 32796935
- Bailey MH, Meyerson WU, Dursi LJ, Wang LB, Dong G, Liang WW, Weerasinghe A, Li S, Li Y, Kelso S; MC3 Working Group; PCAWG novel somatic mutation calling methods working group; Saksena G, Ellrott K, Wendl MC, Wheeler DA, Getz G, Simpson JT, Gerstein MB, Ding L; PCAWG Consortium. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 2020 Sep 21;11(1):4748. doi: 10.1038/s41467-020-18151-y. PMID: 32958763
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2019
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2018
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2017
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2016
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