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HOME > Research progress / Achievements > Achievements > 2012-2013: Proposed research project 07
Achievements

2012-2013: Proposed research project 07

Molecular mechanism underlying Aspp1 function in lymphatic vascular formation and maintenance
Outline
Research progress
Leader : Masanori Hirashima

Original Papers

  • Majima, T., Takeuchi, K., Sano, K., Hirashima, M., Okamoto, M.T., Ishizaki, H., Miyoshi, J., Ogita, H. An adaptor molecule Afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo. PLoS One 8(6): e68134, 2013.
  • Katsuta, H., Fukushima, Y., Maruyama, K., Hirashima, M., Nishida, K., Nishikawa, S.I., Uemura, A. EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries. Invest. Ophthalmol. Vis. Sci. 54(6): 4102-4108, 2013.
  • Ikushima, Y.M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H., Suda, T. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem. Biophys. Res. Commun., 430(1): 20-25, 2013.
  • Kusuhara, S., Fukushima, Y., Fukuhara, S., Jakt, L.M., Okada, M., Shimizu, Y., Hata, M., Nishida, K., Negi, A., Hirashima, M., Mochizuki, N., Nishikawa, S., Uemura, A. Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells. PLoS One 7(9): e45858, 2012.
  • Osada, M., Inoue, O., Ding, G., Shirai, T., Ichise, H., Hirayama, K., Takano, K., Yatomi, Y., Hirashima, M., Fujii, H., Suzuki-Inoue, K., Ozaki, Y. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J. Biol. Chem. 287(26): 22241-22252, 2012.
  • Sano, K., Katsuta, O., Shirae, S., Kubota, Y., Ema, M., Suda, T., Nakamura, M., Hirashima, M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. Biochem. Biophys. Res. Commun. 420(2): 422-427, 2012.
2012-2013: Project 06 Index of Projects 2012-2013: Project 08
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