Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

HOME > Research progress / Achievements > Achievements > 2012-2013: Proposed research project 08

2012-2013: Proposed research project 08

Molecular mechanisms regulating the morphogenesis of bile ducts

Leader :

Naoki Tanimizu

Tanimizu, N., Nakamura, Y., Ichinohe, N., Mizuguchi, T., Hirata, K., and Mitaka, T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J. Cell Sci. 126: 5239-5246, 2013.
Kiyohashi, K., Kakinuma, S., Kamiya, A., Sakamoto, N., Nitta, S., Yamanaka, H., Yoshino, K., Fijuki, J., Murakawa, M., Kusano-Kitazume, A., Shimizu, H., Okamoto, R., Azuma, S., Nakagawa, M., Asahina, Y., Tanimizu, N., Kikuch, A, Nakauchi, H., Watanabe, M. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells. Hepatology 57:2502-2513, 2013.
Tanimizu, N., Kikkawa, Y., Mitaka, T., and Miyajima, A. α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals. J. Biol. Chem. 287: 28586-28597, 2012.
Senga, K., Mitaka, T., Mostov, KE., Miyajima, A., and Tanimizu, N. Grhl2 regulates epithelial morphogenesis by establishing functional tight junctions through upregulation of Cldn3, Cldn4, and Rab25. Mol. Biol. Cell 23: 2845-2855, 2012.

Tanimizu, N. and Mitaka, T. Role of grainyhead-like 2 in the formation of functional tight junctions. Tissue Barrier 1(1): e23495, 1-5, 2013.