Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2012-2013: Proposed research project 17

Functional analysis of the tumor suppressor APC in epithelial tubulogenesis and colorectal tumorigenesis

Leader :

Yoshihiro Kawasaki

Tsuji, S.*, Kawasaki, Y.*, Furukawa, S., Taniue, K., Hayashi, T., Okuno, M., Hiyoshi, M., Kitayama, J., Akiyama, T. (* co-first author) The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis. Nat. Commun. 5: 3150, 2014.
Furukawa, S., Kawasaki, Y., Miyamoto, M., Hiyoshi, M., Kitayama, J., Akiyama, T. The miR-1-Notch3-Asef pathway is important for colorectal tumor cell migration. PLoS One 8: e80609, 2013.
Kawasaki, Y., Furukawa, S., Sato, R., Akiyama, T. Differences in the localization of the adenomatous polyposis coli-Asef/Asef2 complex between adenomatous polyposis coli wild-type and mutant cells. Cancer Sci. 104: 1135-1138, 2013.