2024

Hong, B., Ohtake, Y., Itokazu, T. and Yamashita, T. (2024) Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction. Cell Death Discovery Fukuda, M., Fujita, Y., Hino, Y., Nakano, M., Shirahige, K. and Yamashita, T. (2024) Inhibition of HDAC8 reduces the proliferation of adult neural stem cells in the subventricular zone. Int. J. Mol. Sci. Katsu, M., Sekine-Tanaka, M., Tanaka, M., Horai, M., Akarsuka, A., Suga, M., Kiyohara, K., Fujita, T., Sasaki, A. and Yamashita, T. (2024) Inhibition of repulsive guidance molecule-a ameliorates compromised blood–spinal cord barrier integrity associated with neuromyelitis optica in rats. J. Neuroimmunol. Hamano, S., Yoshimizu, T., Mori, M., Iida, A. and Yamashita, T. (2024) Characterization of pathological stages in a mouse model of progressive multiple sclerosis. Neurosci. Res.

2023

Shimizu, M., Shiraishi, N., Tada, S., Sasaki, T., Beck G., Nagano, S., Kinoshita, M., Sumi, H., Sugimoto, T., Ishida, Y., Koda, T., Ishikura, T., Sugiyama, Y., Kihara, K., Kanakura, Y., Nakajima, T., Takeda, S, Takahashi, M.,Yamashita, T., Okuno, T., Mochizuki, H. (2023) RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. Sci. Adv. 9, eadg3193. Tsujioka, H. and Yamashita, T. (2023) Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker. Front. Cell. Neurosci. 17:1097512. Shibuya, N., Itokazu, T., Ueda, T. and Yamashita, T. (2023) Intravital imaging reveals the ameliorating effect of colchicine in a photothrombotic stroke model via inhibition of neutrophil recruitment. Trans. Stroke Res. 14, 100-110. Kuroda, Y., Iwata-Otsubo, A., Dias, K.R., Temple, S.E.L., Nagao, K., Hayr, L.D., Zhu, Y., Isobe, S.Y., Nishibuchi, G., Fiordaliso, S.K., Fujita, Y., Ritter, A.L., Baker, S.W., Leung, M.L., Koboldt, D.C., Harman, A., Keena, B.A., Izumi, K., Subramanian, G.M., Manickam, K., Schmalz, B., Latsko, M., Zackai, E.H., Edwards, M., Evans, C.A., Dulik, M.C., Buckley, M.F., Yamashita, T., Timothy, W., Robert, O., Harvey, J., Obuse, C., Roscioli, T., Izumi, K. (2023) Dominant-negative variants in CBX1 cause a neurodevelopmental disorder. Genet. Med. 25, 100861. Furumiya, T., Itokazu, T., Nakanishi, T. and Yamashita, T. (2023) CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice. Neurosci. Res.191, 38-47. Matsudaira, T., Nakano, S., Konishi, Y., Kawamoto, S., Uemura, K., Kondo, T., Sakurai, K., Ozawa, T., Hikida, T., Komine, O., Yamanaka, K., Fujita, Y., Yamashita, T., Matsumoto, T. and Hara, E. (2023) Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Comm. Biol. 6, 665. Sawada, M., Yoshino-Saito, K., Ninomiya, T., Oishi, T., Yamashita, T., Hirotake, O., Takada, M., Nishimura, Y. and Isa, T. (2023) Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys. eNeuro Abbaoui, A., Fatoba, O. and Yamashita, T. (2023) Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases. Front. Cell. Neurosci. 17, 1181071. Mohamed, W., Kumar, J., Alghamdi, B.S., Soliman, A.H. and Yamashita, T. (2023) Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives. IBRO Rep. 14, 95-110.

2022

Iwamoto, S., Itokazu, T., Sasaki, A., Kataoka, H., Tanaka, S., Hirata, T., Miwa, K., Suenaga, T., Takai, Y., Misu, T., Fujihara, K. and Yamashita, T. (2022) RGMa signal in macrophages induces neutrophil-related astrocytopathy in NMO. An. Neurol.91, 532-547. Hasebe, R., Murakami, K., Harada, M., Halaka, N. Nakagawa, H., Kawano, F., Ohira, Y., Kawamoto, T., Yull, F.E., Blackwell, T.S., Nio-Kobayashi, J., Iwanaga, T., Watanabe, M., Watanabe, N., Hotta, H., Yamashita, T., Kamimura, D., Tanaka, Y. and Murakami, M. (2022) ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. J. Exp. Med. 219, e20212019. Morita, Y., Itokazu, T., Nakanishi, T., Hiraga, S. and Yamashita, T. (2022) A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations. J. Neuroinflamm. 19, 263. Hirata, T., Itokazu, T., Sasaki, A., Sugihara, F. and Yamashita, T. (2022) Humanized anti-RGMa antibody treatment promotes repair of blood-spinal cord barrier under autoimmune encephalomyelitis in mice. Front. Immunol. 13, 870126. Ikeda-Yorifuji, I., Tsujioka, H., Sakata, Y. and Yamashita, T. (2022) Single-nucleus RNA sequencing identified cells with ependymal cell-like features enriched in neonatal mice after spinal cord injury. Neurosci. Res.181,22-38. Ahmed, K.M.A.A., Nakagawa, H., Isaksen, T.J., and Yamashita, T. (2022) The effects of Bone Morphogenetic Protein 4 on adult neural stem cell proliferation, differentiation and survival in an in vitro model of ischemic stroke. Neurosci. Res.183,17-29. Nishibe, M., Toyoda, H., Hiraga, S., Yamashita, T., Katsuyama, Y. (2022) Synaptic and genetic bases of impaired motor learning associated with modified experience-dependent cortical plasticity in heterozygous reeler mutants. Cereb. Cortex 32, 504-519. Hiraga, S, Itokazu, T., Nishibe, M. and Yamashita, T. (2022) Neuroplasticity related to chronic pain and its modulation by microglia. Inflammation and Regeneration 42, 15. Ninomiya, T., Nakagawa, H., Inoue, K., Nishimura, Y., Oishi, T., Yamashita, T. and Takada, M. (2022) Origin of multisynaptic corticospinal pathway to forelimb segments in macaques and its reorganization after spinal cord injury. Front. Neural Circuit 16, 847100. Fatoba, O., Itokazu, T. and Yamashita, T. (2022) Complement cascade functions during brain development and neurodegeneration. FEBS J. 289, 2085-2109. Mohamed, W.M.Y., Yi, C., Soreq, L. and Yamashita, T. (2022) Editorial: Genes and aging: From bench-to-bedside. Front. Aging Neurosci. 14, 886967. Mohamed, W. and Yamashita, T. (book editors) (2022) Role of micronutrients in brain health. Springer.

2021

Ito, M., Muramatsu, R., Kato, Y., Sharma, B., Uyeda, A., Tanabe, S., Fujimura, H., Kidoya, H., Takakura, N., Kawahara, Y., Takao, M., Mochizuki, H., Fukamizu, A. and Yamashita, T. (2021) Age-dependent decline in myelination capacity is mediated by apelin-APJ signaling. Nature Aging 1, 284-294. Oda, W., Fujita, Y., Baba, K., Mochizuki, H., Niwa, H. and Yamashita, T. (2021) Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease. Cell Death Dis. 12, 181. Miyajima, H., Itokazu, T., Tanabe, S. and Yamashita, T. (2021) Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice. Cell Death Dis. 12, 766. Honjo, Y., Fujita, Y., Niwa, H. and Yamashita, T. (2021) Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury. PLOS ONE 16, e0251013. Yamanaka, H., Tanaka, Y., Nakagawa, H., Yamanaka-Isosaka, T., Yamashita, T. and Takada, M. (2021) An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury. PLOS ONE 16, e0252023. Parajuli, G., Tekguc, M., Wing, J.B., Hashimoto, A., Okuzaki, D., Hirata, T., Sasaki, A., Itokazu, T., Handa, H., Sugino, H., Nishikawa, Y., Metwally, H., Kodama, Y., Tanaka, S., Sabe, H., Yamashita, T., Sakaguchi, S., Kishimoto, T. and Hashimoto, S. (2021) Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression. Cancer Immunol. Res. 9, 862-876. Matoba, K., Yamashita, S., Isaksen, T.J. and Yamashita, T. (2021) Proton-sensing receptor GPR132 facilitates migration of astrocytes. Neurosci. Res.170,106-113. Tsujioka, H. and Yamashita, T. (2021) Neural circuit repair after central nervous system injury. Int. Immunol.33,301-309. Fujita, Y. and Yamashita, T. (2021) Mechanisms and significance of microglia-axon interactions in physiological and pathophysiological conditions. Cell. Mol. Life. Sci.78,3907-3919. Fujita, Y. and Yamashita, T. (2021) Alterations in chromatin structure and function in the microglia. Front. Cell Dev. Biol. 8, 626541. Fujita, Y. and Yamashita, T. (2021) Neuroprotective function of microglia in the developing brain. Neuronal Signal. 5, NS20200024. Ahmed, A.K.M.A., Isaksen, T.J. and Yamashita, T. (2021) Preparation of mouse adult neural stem cells. Star Protocols 2, 100522.

2020

Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S. and Yamashita, T. (2020) Netrin-G1 regulates microglial accumulation along axons and supports the survival of layer V neurons in the postnatal mouse brain. Cell Rep. 31, 107580. Isaksen, T.J., Fujita, Y. and Yamashita, T. (2020) Repulsive guidance molecule A suppresses adult neurogenesis. Stem Cell Rep. 14, 677-691. Hiraga, S., Itokazu, T., Hoshiko, M., Takaya, H., Nishibe, M and Yamashita, T. (2020) Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting of the thalamo-cortical projection in mice. JCI Insight 5, e131801 Sada, N., Fujita, Y., Mizuta, N., Ueno, M., Furukawa, T. and Yamashita, T. (2020) Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury. Cell Death Dis. 11, 655. Nakazato, Y., Fujita, Y., Nakazato, M. and Yamashita, T. (2020) Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis. Sci. Rep. 10, 7354. Abe, Y., Honsho, M., Kawaguchi, R., Matsuzaki, T., Ichiki, Y., Fujitani, M., Fujiwara, K., Hirokane, M., Oku, M., Sakai, Y., Yamashita, T., Fujiki, Y. (2020) A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurrotrophic factor pathway. J. Biol. Chem. 295, 5321-5334. Ozaki, T., Muramatsu, R., Nakamura, H., Kinoshita, M., Kishima, H. and Yamashita, T. (2020) Proteomic analysis of protein changes in plasma by balloon test occlusion. J. Clin. Neurosci. 72, 397-401. Tanabe, S. and Yamashita, T. (2020) Function of lymphocytes in oligodendrocyte development. Neuroscientist 26, 74-86. Fatoba, O., Ohtake, Y., Itokazu, T. and Yamashita, T. (2020) Immunotherapies in PolyQ disorders and α-Synucleinopathies. Front. Immunol. 11, 337. Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, AJ., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K. and Kuroiwa, T. (2020) Recent insights into peroxisome biogenesis and associated diseass. J. Cell Sci. 133, jcs236943. Fatoba, O, Itokazu, T. and Yamashita, T. (2020) Microglia as therapeutic target in central nervous system disorders. J. Pharmacol. Sci. 144, 102-118. Isaksen, T.J. and Yamashita, T. (2020) Repulsive guidance molecule A regulates adult neurogenesis via the Neogenin receptor. Neurosci. Insights 15, 2633105520948481. Abe, Y., Nishimura, Y., Nakamura, K., Tamura, S., Honsho, M., Udo, H., Yamashita, T. and Fujiki, Y. (2020) Peroxisome deficiency impairs BDNF signaling and memory. Front. Cell Dev. Biol. 8, 567017. Fujita, Y. and Yamashita, T. (2020) Protocol for co-culture of microglia with axons. STAR Protocols 1, 100111.

2019

Hamaguchi, M., Muramatsu, R., Fujimura, H., Mochizuki, H., Kataoka, H. and Yamashita, T. (2019) Circulating transforming growth factor-b1 facilitates remyelination in the adult central nervous system. eLife 8, e41869. Yamada, M., Fujita, Y., Hayano, Y., Hayakawa, H., Baba, K., Mochizuki, H. and Yamashita, T. (2019) Increased expression of fibronectin leucine-rich transmembrane protein 3 in the dorsal root ganglion induces neuropathic pain in rats. J. Neurosci. Nakanishi, T., Fujita, Y. and Yamashita, T. (2019) Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury. Cell Death Dis. 10, 67. Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M. (2019) Treatment with the neutralizing antibody against repulsive guidance molecule-a promotes recovery from impaired manual dexterity in a primate model of spinal cord injury. Cereb Cortex 29, 561-572. Tanabe, S., Saitoh, S., Miyajima, H., Itokazu, T. and Yamashita, T. (2019) Microglia suppress the secondary progression of autoimmune encephalomyelitis. Glia 67, 1694-1704. Tsujioka, H. and Yamashita, T. (2019) Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice. BMC Genomics 20, 619. Hosomi, S., Koyama, Y., Watabe, T., Ohnishi, M., Ogura, H., Yamashita, T. and Shimazu, T. (2019) Myeloid-derived suppressor cells infiltrate the brain and suppress neuroinflammation in a mouse model of focal traumatic brain injury. Neuroscience 406, 457-466. Nakanishi, T., Fujita, Y. and Yamashita, T. (2019) Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury. Neurosci. Lett. 709, 134329. Yamashita, T. (2019) Neogenin is a determining factor for regenerating neurons following spinal cord injury. Neurosci. Fujita, Y. and Yamashita, T. (2019) The effects of leptin on glial cells in neurological diseases. Front. Neurosci. 13, 828. Fujita, Y. and Yamashita, T. (2019) Roles of effector T cells in neurological autoimmunity. Neuroimmune Diseases-From cells to the living brain. Springer, p63-81. Araki, T and Yamashita, T. (2019) Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications. Neurosci. Res. 139, 1-2. Tanabe, S. and Yamashita, T. (2019) B lymphocytes: crucial contributors to brain development and neurological diseases. Neurosci. Res. 139, 37-41.

2018

Tanabe, S. and Yamashita, T. (2018) B-1a lymphocytes promote oligodendrogenesis during brain development. Nat. Neurosci.21, 506-516. Kawakami, Y., Kurihara, Y., Saito, Y., Fujita, Y., Yamashita, T. and Takei, K. (2018) The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. J. Neurosci. 38, 2589-2604. Zhang, S., Fujita, Y., Matsuzaki, R. and Yamashita, T. (2018) Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury. Cell Death Dis. 9,460. Tanabe, S., Fujita, Y., Ikuma, K. and Yamashita, T. (2018) Inhibiting repulsive guidance molecule A suppresses secondary progression in mouse models of multiple sclerosis. Cell Death Dis. 9, 1061. Lin, H., Muramatsu, R., Maedera, N., Tsunematsu, H., Hamaguchi, M., Koyama, Y., Kuroda, M., Ono, K., Sawada, M. and Yamashita, T. (2018) Extracellular lactate dehydrogenase A release from damaged neurons drives central nervous system angiogenesis. EBiomedicine 27, 71-85. Harada, K., Fujita, Y., Okuno, T., Tanabe, S., Koyama, Y., Mochizuki, H. and Yamashita, T. (2018) Inhibition of RGM alleviates symptoms in a rat model of neuromyelitis optica. Sci. Rep. 8, 34. Nishibe, M., Katsuyama, Y. and Yamashita, T. (2018) Developmental abnormality contributes to cortex-dependent motor impairments and higher intracortical current requirement in the reeler homozygous mutants. Brain Structure and Function Csoka, B., Nemeth, Z., Szabo, I., Davies, D., Varga, Z., Paloczi, J., Falzoni, S., Virgilio, F. D., Muramatsu, R., Yamashita, T., Pacher, P and Haskó, G. (2018) Macrophage P2X4 receptors augment bacterial killing and protect against sepsis. JCI Insight 3, e99431. Abe, Y., Honsho, M.,Kawaguchi, R., Itoh, R., Fujitani, M., Fujiwara, K.,Hirokane, M., Matsuzaki,T., Nakayama, K., Muratani, T., Nakayama, K.I.,Yamashita, T. and Fujiki, Y. (2018) Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of cerebellum. Life Sci. Alliance 1, e201800062. Fukunaga, T., Fujita, Y., Kishima, H. and Yamashita, T. (2018) Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma. PLoS ONE 13, e0206552. Nakasone, A., Muramatsu, R., Kato, Y., Kawahara, Y. and Yamashita, T. (2018) Myotube-derived factor promotes oligodendrocyte precursor cell proliferation. Biochem. Biophys. Res. Commun. 500, 609-613. Hosomi, S., Watabe, T., Mori, Y., Koyama, Y., Adachi, S., Hoshi, N., Ohnishi, M., Ogura, H., Yoshioka, Y., Hatazawa, J., Yamashita, T. and Shimazu, T. (2018) Inflammatory projections after focal brain injury trigger neuronal network disruption. Neuroimage: Clinical 20, 946-954. Fujita, Y. and Yamashita, T. (2018) Sirtuins in Neuroendocrine Regulation and Neurological Diseases. Front. Neurosci. 12, 778. Fujita, Y. and Yamashita, T. (2017) Spatial organization of genome architecture in neural development and disease. Neurochem. Int. 119, 49-56. Tanabe, S. and Yamashita, T. (2018) The role of immune cells in brain development and neurodevelopmental diseases. Int. Immunol. 30, 437-444.

2017

Fujitani, M., Zhang, S., Fujiki, R., Fujihara, Y. and Yamashita, T. (2017) A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Mol. Psychiatry 22, 364-374. Kuroda, M., Muramatsu, R., Maedera, N., Koyama, Y., Hamaguchi, M., Fujimura, H., Yoshida, M., Konishi, M., Itoh, N., Mochizuki, H. and Yamashita, T. (2017) Peripherally derived FGF21 promotes remyelination in the central nervous system. J. Clin. Invest. Fujita, Y., Masuda, K., Bando, M., Nakato, R., Katou, Y., Tanaka, T., Nakayama, M., Takao, K., Miyakawa, T., Tanaka, T., Ago, Y., Hashimoto, H., Shirahige, K. and Yamashita, T.(2017) Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J. Exp. Med.214, 1431-1452. Siebold, C., Yamashita, T., Monnier, P., Mueller, B.K. and Pasterkamp, R.J. (2017) RGMs: Structural Insights, Molecular Regulation and Downstream Signaling. Trends Cell Biol. 27, 365-378. van Battum, E.Y., Verhagen, M.G., Vangoor, V., Fujita, Y., Derijck, A.A.H.A., EO’Duibhir, E., Giuliani, G., de Gunst, G., Adolfs, Y., Lelieveld, D., Egan, D., Schaapveld, R., Yamashita, T. and Pasterkamp, R.J. (2017) An image-based miRNA screen identifies miRNA-135s as regulators of CNS axon growth and regeneration by targeting Krüppel-like Factor 4. J. Neurosci. Ishizuka, K., Fujita, Y., Kawabata, T., Kimura, H., Iwayama, Y., Inada, T., Okahisa, Y., Egawa, J. Usami, M., Kushima, I., Uno, Y., Okada, T., Ikeda, M., Aleksic, B., Mori, D., Someya, T. Yoshikawa, T., Iwata, N., Nakamura, H., Yamashita, T. and Ozaki, N. (2017) Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Transl. Psychiatry 7, e1184. Kimura, H., Fujita, Y., Kawabata, T., Ishizuka,K., Wang, C., Iwayama, Y., Okahisa, Y., Kushima, I., Morikawa, M., Uno, Y., Okada, T., Ikeda, M., Inada,T., Branko, A., Mori, D., Yoshikawa, T., Iwata, N., Nakamura, H., Yamashita, T. and Ozaki, N. (2017) A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to Schizophrenia susceptibility. Transl. Psychiatry Fujitani, M., Sato, R. and Yamashita, T. (2017) Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis. Sci. Rep. 7, 12007.    Kanemitsu, Y., Fujitani, M., Fujita, Y., Zhang, S., Su, Y.Q., Kawahara, Y. and Yamashita, T. (2017) The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Sci. Rep. 7, 1155. Matoba, K., Muramatsu, R. and Yamashita, T. (2017) Leptin sustains spontaneous remyelination in the adult central nervous system. Sci. Rep. 7, 40397. Kawai, T., Okochi, Y., Ozaki, T., Imura, Y., Koizumi, S., Yamazaki, M., Abe, M., Sakimura, K., Yamashita, T. and Okamura, Y. (2017) Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production. J. Neurochem. Fujita, Y. and Yamashita, T. (2017) The roles of RGMa-neogenin signaling in inflammation and angiogenesis. Inflammation and Regeneration 37, 6. Fujita, Y. and Yamashita, T. (2017) Spatial organization of genome architecture in neural development and disease. Neurochem. Int.     Matoba, K., Muramatsu, R. and Yamashita, T. (2017) The role of leptin in the central nervous system remyelination. Receptors & Clinical Investigation. Hamaguchi, M., Muramatsu, R., Matoba, K., Maedera, N., Yamashita, T.(2017) Lysophosphatidylcholine-induced demyelination model of mouse. Protocol Exchange

2016

Hayano, Y., Takasu, K., Koyama, Y., Ogawa, K., Minami, K., Asaki, T., Kitada, K., Kuwabara, S. and Yamashita, T. (2016) Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. J. Exp. Med.213, 2949-2966. Itami, C., Huang, J.Y., Yamasaki, M., Watanabe, M., Lu, H.C. and Kimura, F. (2016) Developmental switch in spike timing-dependent plasticity and cannabinoid -dependent reorganization of the thalamocortical projection in the barrel cortex. J. Neurosci. 36, 7039-7054 Fujiwara, K., Fujita, Y., Kasai, A., Onaka, Y., Hashimoto, H., Okada, H. and Yamashita, T. (2016) Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior, and memory deficits in mouse. Transl. Psychiatry 6, e766. Ozaki, T., Muramatsu, R., Sasai, M., Yamamoto, M., Kubota, Y., Fujinaka, T., Yoshimine, T. and Yamashita, T. (2016) The P2X4 receptor is required for neuroprotection via ischemic preconditioning. Scientific Reports 6, 25893 Harada, K., Fujita, Y. and Yamashita, T. (2016) Repulsive guidance molecule A suppresses angiogenesis. Biochem. Biophys. Res. Commun. 469, 993-999. Hamasaki, H., Fujitani, M. and Yamashita, T. (2016) NME2 associates with PTPs to transduce signals from chondroitin sulfate proteoglycans. Biochem. Biophys. Res. Commun.471, 522-527. Kuroda, M., Muramatsu, R., and Yamashita, T. (2016) Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation.Biochem. Biophys. Res. Commun. 482, 1160-1164. Jin, X. and Yamashita, T. Microglia in central nervous system repair after injury. J. Biochem.159, 491-496.

2015

van Erp, S., van den Heuvel, D.M.A., Fujita, Y., Robinson, R.A., Hellemons, A.J., Adolfs, Y., Van Battum, E.Y., Blokhuis, A.M., Kuijpers, M., Demmers, J., Hedman, H., Hoogenraad, C.C., Siebold, C., Yamashita, T. and Pasterkamp, R.J. (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev. Cell 35, 537-552. Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki, T., Higuchi, K., Morimoto, Y., Wieghofer, P., Okada, Y., Mori, Y., Sakoda, S., Saika, S., Yoshioka, Y., Komuro, I., Yamashita, T., Hirano, T., Prinz, M., Murakami, M. (2015) Pain-mediated sympathetic activation induces relapse via microglia accumulation in a multiple sclerosis model. eLIFE 4, e08733. Miyake, S., Muramatsu, R., Hamaguchi, M. and Yamashita, T. (2015) Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury. Cell Death Dis. 6, e1638 Muramatsu, R., Kuroda, M., Matoba, K., Hsiaoyun, L., Takahashi, C., Koyama, Y., Yamashita, T. (2015) Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J. Biol. Chem. 290, 11515-25.. Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M. (2015) Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. Sci. Rep. 5, 11986. Fujita, Y., Fujiwara, K., Zenitani, S. and Yamashita, T. (2015) Acetylation of NDPK-D regulates its subcellular localization and cell survival. PLoS ONE 10, e0139616. Toda, T., Ishida, K., Kiyama, H. Yamashita, T. and Lee, S. (2015) Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity. PLoS ONE 9, e114328. Hirano, M., Satake, W., Ihara, K., Tsuge, I., Kondo, S., Betsui, H., Okubo, K., Sakamoto, H., Ueno, S., Ikuno, Y., Ishihara, R., Iwahashi, H., Ohishi, M., Mano, T., Yamashita, T., Suzuki, Y., Nakamura, Y., Kusunoki, S. and Toda, T. (2015) The first nationwide survey and genetic analyses of Bardet-Biedl syndrome. PLoS ONE 10, e0136317. Yamashita, T. (2014) Significance of corticospinal tract sprouting after cortical injury in rodents. J. Neurosci. Neuroeng. In press. Sumimoto, S., Muramatsu, R., Yamashita, T. (2015) Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling. Brain Res. 1594, 46-51. Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Neuroprotection and Neuroregeneration for retinal diseases, Springer, p175-187.

2014

Tanabe, S. and Yamashita, T. (2014) Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis.Cell Rep. 9, 1459-1470. Ueno, M., Fujiki, R. and Yamashita, T. (2014) A selector orchestrates cortical function. Nat. Neurosci. 17, 1016-1017. Hayano, Y., Sasaki, K., Ohmura, N., Takemoto, M., Maeda, Y., Yamashita, T., Hata, Y., Kitada, K and Yamamoto, N. (2014) Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion. Proc. Natl. Acad. Sci. USA 111, 15226-15231. Ueno, M. and Yamashita, T. (2014) Bidirectional tuning of microglia in the developing brain: From neurogenesis to neural circuit formation. Curr. Opin. Neurobiol 27C, 8-15. Lee, S., Toda, T., Kiyama, H. and Yamashita, T. (2014) Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice. Cell Death Dis. 5, e1007. Zhang, S., Kanemitsu, Y., Fujitani, M. and Yamashita, T. (2014) The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Sci. Rep 4, 5984. Suehiro, K., Nakamura, Y., Xu, S., Uda, Y., Matsumura, T., Yamaguchi, Y., Okamura, H.Yamashita, T. and Takei, Y. (2014) Ecto-domain phosphorylation promotes functional recovery from spinal cord injury. Sci. Rep. 4, 4972. Itokazu, T., Hayano, Y., Takahashi, R. and Yamashita, T. (2014) Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. Neurosci. Res 79, 34-40. Sumimoto, S., Muramatsu, R., Fujii, S., Yamashita, T. (2014) Vascular endothelial cells promote cortical neurite outgrowth via an integrin beta3-dependent mechanism. Biochem. Biophys. Res. Commun 450, 593-597. Fujita, Y. and Yamashita, T. (2014) Role of DAPK in neuronal cell death. Apoptosis 19, 339-345. Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Springer. Ueno, M. and Yamashita, T. (2014) The brain-immune network in spinal cord injury, Springer. Fujita, Y and Yamashita, T. (2014) Axon growth inhibition by Rho/ROCK. Front. Neurosci. Muramatsu, R. and Yamashita, T. (2014) Concept and molecular basis of axonal regeneration after central nervous system injury. Neurosci Res. 78, 45-49. Muramatsu, R. and Yamashita, T. (2014) Pericyte function in the physiological central nervous system. Neurosci Res. 81-82, 38-41. Kimura, Y., Fujita, Y. and Yamashita, T. (2014) Effect of the Sigma-1 receptor on neurite outgrowth. Receptors & Clinical Investigation 1, 8-12. Fujita, Y and Yamashita, T. (2014) The functions and signaling pathways induced by the interactions of APP–related molecules with p75NTR. Receptors & Clinical Investigation 1, 299-303.

2013

Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M. and Yamashita, T. (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543-551. Fujiki, R., Sato, A., Fujitani, M. and Yamashita, T. (2013) A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. Cell Death Dis. 4, e677. Nakagawa, H., Ueno, M., Itokazu, T. and Yamashita, T. (2013) Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice. Cell Death Dis. 4, e534. Uesugi, N., Kimura, Y. and Yamashita, T. (2013) Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve. Cell Death Dis. 4, e557. Tanaka, T., Fujita, Y., Ueno, M., Shultz, L.D. and Yamashita, T. (2013) Suppression of SHP-1 promotes functional corticospinal tract rewiring after brain injury. Cell Death Dis. 4. e567. Onishi, M., Fujita, Y., Yoshikawa, H. and Yamashita, T. (2013) Inhibition of Rac1 promotes BMP-2–induced osteoblastic differentiation. Cell Death Dis. 4, e698. Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T. and Yamashita, T. (2013) ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 4, e710. Fujita, Y., Sato, A. and Yamashita, T. (2013) Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation. Cell Death Dis. 4. E763. Takahashi, C., Muramatsu, R., Fujimura, H., Mochizuki, H. and Yamashita, T. (2013) Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination. Cell Death Dis. 4, e795. Kimura, Y., Fujita, Y., Shibata, K., Mori, M. and Yamashita, T. (2013) Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling. PLoS ONE 8, e75760. Hasebe, N., Fujita, Y., Ueno, M., Yoshimura, K., Fujino, Y. and Yamashita, T. (2013) Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS ONE Fujiki, R., Sato, A., Hata, K., Tashiro, F., Yasuhara, Y., Miyazaki, J., Yoneda, Y., Fujitani, M. and Yamashita, T. (2013) Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis. Biochem. Biophys. Res. Commun. 430, 604-609. Shibata, K., Nakahara, S., Shimizu, E., Yamashita, T., Matsuki, N. and Koyama, R. (2013) Repulsive guidance molecule a (RGMa) regulates axonal morphogenesis in the hypocampus. NeuroReport 24, 609-615.

2012

Muramatsu, R., Takahashi, C., Miyake, S., Fujimura, H., Mochizuki, H. and Yamashita, T. (2012) Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nature Medicine 18, 1658-1664. Ueno, M., Hayano, Y., Nakagawa, H. and Yamashita, T. (2012) Intraspinal rewiring of the corticospinal tract requires target-derived BDNF and compensates lost function after brain injury. Brain 135, 1253-1267. Tanokashira, D., Morita,T., Hayashi, K., Mayanagi, T., Fukumoto, K., Kubota, Y., Yamashita, T. and Sobue, K. (2012) Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. J. Neurosci. 32, 14583-14560. Ishii, H., Jin, X., Ueno, M., Tanabe, S., Kubo, T., Serada, S., Naka, T. and Yamashita, T. (2012) Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Cell Death Dis. 3, e363. Kurihara, D. and Yamashita, T. (2012) Chondroitin sulfate proteoglycans downregulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB). J. Biol. Chem. 287, 13822-13828. Itokazu, T., Fujita, Y., Takahashi, R. and Yamashita, T. (2012) Identification of the neogenin-binding site on the repulsive guidance molecule a.  PLoS One 7, e32791. Jin, X., Ishii, H., Bai, Z., Itokazu, T. and Yamashita, T. (2012) Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. PLoS ONE 7, e41892. Kubo, T., Tokita, S. and Yamashita, T. (2012) Repulsive guidance molecule-a and demyelination: Implications for multiple sclerosis. J. Neuroimmune Pharmacol. 7, 524-528.

2011

Muramatsu, R., Kubo, T., Mori, M., Nakamura, Y., Fujita, Y., Akutsu, T., Okuno, T., Taniguchi, J., Kumanogoh, A., Yoshida, M., Mochizuki, H., Kuwabara, S. and Yamashita, T. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nature Medicine 17, 488-494. Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y, Irie, S., Ueno, S., Koyasu, T., Matsui, R., Cherasse, Y., Urade, Y., Watanabe, D., Kondo, M., Yamashita, T. and Furukawa, T. (2011)miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nature Neurosci. Fujita, Y., Endo, S., Takai, T. and Yamashita, T. (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 30, 1389-1401. Yamagishi, S., Hampe1, F., Hata, K., del Toro, D., Schwark, M., Kvachnina, E., Bastmeyer, M., Yamashita, T., Tarabykin, V., Klein, R. and Egea. J. (2011) FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 30, 2920-2933. Lee, S., Ueno, M. and Yamashita, T. (2011) Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling. Cell Death Dis. 2, e133. Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T. Axotomy induces axonogenesis in hippocampal neurons through STAT3. Cell Death Dis. 2, e175. Imagama, S., Sakamoto, K., Tauchi, R., Shinjo, R., Ohgomori, T., Ito, Z., Zhang, H., Nishida, Y., Asami, N., Takeshita, S., Sugiura, N., Watanabe, H., Yamashita, T., Ishiguro, N., Matsuyama, Y. and Kadomatsu K. (2011) Keratan sulfate restricts neural plasticity after spinal cord injury. J. Neurosci. 31, 17091-17102. Nakamura, Y., Fujita, Y., Ueno, M., Takai, T. and Yamashita, T. (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J. Biol. Chem. 286, 1876-1883. Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H. and Yamashita, T. (2011) Neogenin: A receptor for bone morphogenetic proteins. J. Biol. Chem. 286, 5157-5165. Ueno, M. and Yamashita, T. (2011) Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice. Exp. Neurol. 230, 280-290. Kitayama, M., Ueno, M., Itakura, T. and Yamashita, T. (2011) Activated microglia inhibit axonal growth through RGMa.PLoS ONE 6, e25234. Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T. (2011) Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin β. Biochem. Biophys. Res. Commun. 405, 697-702. Fujita, Y., Takashima, R. Endo, S., Takai, T. and Yamashita, T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2, e198. Omoto, S., Ueno, M., Mochio, S. and Yamashita, T. (2011) Corticospinal tract fibers cross the ephrin-B3–negative part of the midline of the spinal cord after brain injury. Neurosci. Res. 69, 187-195. Okamura, Y., Kohmura, E. and Yamashita, T. (2011) TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci. Res. 71, 63-70. Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T. (2011) C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci. Res. 71, 266-277. Ryu, M., Nakazawa, T., Akagi, T., Tanaka, T., Watanabe, R., Yasuda, M., Himori, N, Maruyama, K., Yamashita, T., Abe, T., Akaishi, M. and Nishida, K. (2011) Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone. J. Control. Release 151, 65-73. Hirano, M., Ohishi, M., Yamashita, T., Ikuno, Y., Iwahashi, H., Mano, T., Ishihara, R., Tanaka, I., Yanagihara, K., Isono, C, Sakamoto, H, Nakamura, Y, Kusunoki, S. (2011) Abnormal cystatin C levels in two patients with Bardet-Biedl syndrome. Clin. Med. Insights Case Rep. 4, 17-20. Fang, X., Ueno, M., Yamashita, T. and Ikuno, Y. (2011) RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy. Curr. Eye Res. 36, 1028-1036. Kubo, T., Tokita, S. and Yamashita, T. (2011) Crosstalk between the immune and central nervous systems with special reference to drug development. Drug Development - A Case Study Based Insight into Modern Strategies, Intec Publishers, p365-380.

2010

Omoto, S., Ueno, M., Mochio, S., Takai, T. and Yamashita, T. (2010) Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury. J. Neurosci. 30, 13045-13052. Ito, Z., Sakamoto, K., Imagama, S., Matsuyama, Y., Zhang, H, Hirano, K.,Ando, K., Yamashita, T., Ishiguro, N. and Kadomatsu, K. (2010)　N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. J. Neurosci. 30, 5937-5947. Shinohara, M., Sato, N., Kurinami, H., Takeuchi, D., Takeda, S., Shimamura, M., Yamashita, T., Uchiyama, Y., Rakugi, H. and Morishita, R. (2010) Reduction of brain Ab by Fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance. J. Biol. Chem. 285, 22091-22102. Ishii, H., Kubo, T., Kumanogoh, A. and Yamashita, T. (2010) Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. Biochem. Biophys. Res. Commun.Biochem. Biophys. Res. Commun. 402, 168-172. Aoki, M., Kishima, H., Yoshimura, Y., Ishihara, M., Ueno, M., Hata, K.,Yamashita, T., Iwatsuki, K. and Yoshimine, T. (2010) Transplantation of whole-layer olfactory mucosa promotes restricted functional recovery in rats with complete spinal cord injury. Journal of Neurosurgery: Spine 12,122-130. Kurihara, D., Ueno, M., Tanaka, T. and Yamashita, T. (2010) Expression of galectin-1 in immune cells and glial cells after spinal cord injury. Neurosci. Res. 66, 265-270. Nakayama, J., Takao, T., Kiuchi, H., Yamamoto, K., Fukuhara, S., Miyagawa,Y., Aoki, M., Iwatsuki, K., Yoshimine, T., Ueno, M., Yamashita, T., Nonomura, N., Tsujimura, A. and Okuyama, A. (2010) Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats. J. Urol. 184, 775-782.

2009

Hata, K., Kaibuchi, K., Inagaki, S. and Yamashita, T. (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J. Cell Biol. 184, 737-750. Taniguchi, J., Sawai, S., Mori, M., Kubo, T., Kanai, K., Misawa, S., Isose, S., Yamashita, T. and Kuwabara, S. (2009) CIDP sera inhibit axonal growth of mouse DRG neurons by activation of Rho-kinase. Ann. Neurol. 66, 694-697. Endo, M. and Yamashita, T. (2009) Inactivation of Ras by p120GAP via FAK dephosphorylation mediates RGMa-induced growth cone collapse. J. Neurosci. 29, 6649-6662. Tanaka, T., Ueno, M. and Yamashita, T. (2009) Engulfment of axon debris by microglia requires p38 MAPK activity. J. Biol. Chem. 284, 21626-21636. Miyashita, T., Koda, M., Kitajo, K., Yamazaki, M., Takahashi, K., Kikuchi,A. and Yamashita, T. (2009) Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. J.Neurotrauma. 26, 955-964. Fujita, Y., Yamaguchi, A. Hata, K., Endo, M., Yamaguchi, N. and Yamashita, T. (2009) Zyxin is a novel interacting partner for SIRT1. BMC Cell Biol. 10, 6. Liu, X., Hashimoto, M., Horii, H., Yamaguchi, A., Naito, K. and Yamashita, T. (2009) Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. Biochem. Biophys. Res. Commun. 382, 795-800. Uesugi, N., Muramatsu, R. and Yamashita, T. (2009) Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 383, 509-512. Kohta, M., Kohmura, E. and Yamashita, T. (2009) Inhibition of TGF-ß1 promotes functional recovery after spinal cord injury. Neurosci. Res. 65,393-401. Yamashita, M., Yamauchi, K., Suzuki, M., Eguchi, Y., Orita, S., Endo, M.,Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain. Spine 34, 2270-2277. Yamauchi, K., Inoue, G., Koshi, T., Yamashita, M., Ito, T., Suzuki, M.,Eguchi, Y., Orita, S., Takaso, M., Nakagawa, K., Aoki, Y., Ochiai, N., Kishida, S., Endo, M., Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance P in vitro. Spine 34, 2263-2269. Kurihara, D., Ueno, M., Tanaka, T. and Yamashita, T., (2010) Expression of galectin-1 in immune cells and glial cells after spinal cord injury. Neurosci. Res. In press. Oshima, T., Lee, S., Sato, A., Oda, S., Hirasawa, H. and Yamashita, T. (2009) TNF-α contributes to axonal sprouting and functional recovery following traumatic brain injury. Brain Res. 1290, 102-110. Furuya, T.,Hashimoto, M., Koda, M., Okawa, A., Murata, A., Takahashi, K., Yamashita, T. and Yamazaki, M. (2009) Treatment of spinal cord injury with a rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Res. 1295, 192-202. Aoki, M., Kishima, H., Yoshimura, Y., Ishihara, M., Ueno, M., Hata, K.,Yamashita, T., Iwatsuki, K. and Yoshimine, T. Transplantation of whole-layer olfactory mucosa promotes restricted functional recovery in rats with complete spinal cord injury. Journal of Neurosurgery: Spine in press. Muramatsu R, Ueno M, and Yamashita T. Intrinsic regenerative mechanisms of central nervous system neurons. BioscienceTrend.2009; 3(5):179-183.

2008

Fujita, Y., Taniguchi, J., Uchikawa, M., Endo, M., Hata, K., Kubo, T., Mueller, B.K. and Yamashita, T. (2008) Neogenin regulates neuronal survival through DAP-kinase. Cell Death Differ.15, 1593-1608. Taniguchi, J., Fujitani, M., Endo, M., Kubo, T., Fujitani, M., Miller, F.D., Kaplan, D.R. and Yamashita, T. (2008) Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Cell Death Differ.15, 408-419. Ohshima, Y., Kubo, T., Koyama, R., Ueno, M., Nakagawa, M. and Yamashita, T. (2008) Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1a. J. Neurosci.28, 8344-8353. Ohnami, S., Endo, M., Hirai, S., Uesaka, N., Hatanaka, Y., Yamashita, T. and Yamamoto, N. (2008) Role of RhoA in Activity-Dependent Cortical Axon Branching. J. Neurosci. 28, 9117-9121. Tohyama, D., Yamaguchi, A., and Yamashita, T. (2008) Inhibition of eIF2Bdelta/F11A3.2 during adulthood extends lifespan in Caenorhabditis elegans. FASEB J.22, 4327-4337. Matsuura, I., Taniguchi, J., Hata, K., Saeki, N. and Yamashita, T.(2008) BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J. Neurochem. 105, 1471-1479. Kubo, T., Endo, M., Hata, K., Taniguchi, J., Kitajo, K., Tomura, S.,Yamaguchi, A., Mueller, B.K. and Yamashita, T. (2008) Myosin IIA is required forneurite outgrowth inhibition produced by RGMa. J. Neurochem. 105, 113-126. Schaffer, G., Taniguchi, J., Brodbeck, T., Meyer, A.H., Schmidt, M., Yamashita, T. and Mueller, B.K. (2008) LIM-Only-Protein 4 (LMO4) interacts directly with the RGM A Receptor Neogenin. J. Neurochem. 107, 418-431. Watanabe, T., Ito, T., Inoue, G., Ohtori, S., Kitajo, K., Doya, H., Takahashi, K. and Yamashita, T. The p75 receptor is associated with inflammatory thermal hypersensitivity. J. Neurosci. Res. 86, 3566-3574. Yoshida, J., Kubo, T. and Yamashita, T. Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons. Biochem. Biophys. Res. Commun.372, 725-729. Kawaguchi, K., Ishiwata, S. and Yamashita, T. (2008) Temperature dependence of the flexural rigidity of single microtubules. Biochem Biophys Res Commun.366, 637-642. Suda, M., Hata, K., Sawada, A., Nakamura, Y., Kubo., Yamaguchi, A. and Yamashita, T.(2008) Peptides derived from repulsive guidance molecule act as antagonists.Biochem Biophys Res Commun.371, 501-504. Ueno, M. and Yamashita, T. (2008) Strategies for regenerating injured axons after spinal cord injury-insights from brain development. Biologics: Targets & Therapy.2, 253-264. Kubo, T., Yamaguchi, A., Iwata, N. and Yamashita, T. (2008) The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. Therapeutics and Clinical Risk Management. 4, 605-615.

2007

Yamashita, T., Mueller, B.K. and Hata, K. (2007) Neogenin and RGM signaling in the central nervous system Curr. Opin. Neurobiol. 17, 29-34. Kubo, T., Hata, K., Yamaguchi, A. and Yamashita, T. (2007) Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr. Pharm. Des. 13, 2493-2499. Matsuura, I., Endo, M., Hata, K., Kubo, T., Yamaguchi, A., Saeki, N. and Yamashita, T. (2007) BMP inhibits neurite growth by a mechanism dependent on LIM-kinase. Biochem. Biophys. Res. Commun. 360, 868-873. Kyoto, A., Hata, K. and Yamashita, T. (2007)Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Res.1186, 74-86. Ito, T., Ohtori, S., Hata, K., Inoue, G., Moriya, H., Takahashi, K. and Yamashita, T. (2007) Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Spine 32, 2070-2075. Kaneko, M., Kubo, T., Hata, K., Yamaguchi, A. and Yamashita, T. (2007) Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway. Neurosci. Lett. 423, 62-67. Kubo, T., and Yamashita, T. (2007) Rho-ROCK inhibitors for the treatment of CNS injury. Recent Patents on CNS Drug Discovery 2, 173-179. Endo, M., and Yamashita, T. (2007) Inhibition of Rho/Rho-kinase as therapeutic strategy to promote CNS axonal regeneration. Central Nervous System Agents in Medicinal Chemistry 7, 241-250.

2006

Hata, K., Fujitani, M., Yasuda, Y., Doya, H., Saito, T., Yamagishi, S., Mueller, B.K. and Yamashita, T. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J. Cell Biol. 173,47-58 Mimura, F., Yamagishi, S., Arimura, N., Fujitani, M., Kubo, T., Kaibuchi, K.and Yamashita, T. (2006) MAG inhibits microtubule assembly by a Rho-kinasedependent mechanism. J. Biol. Chem. 281, 15970-15979. Mueller, B.K., Yamashita, T., Schaffer, G. and Mueller, R. (2006) The Role of Repulsive Guidance Molecules (RGMs) in the Embryonic and Adult VertebrateCentral Nervous System. Proc. R. Soc. Lond. Ser. B-Biol. Sci. 361, 1513-1529. Nishio, Y., Koda, M., Kitajo, K., Seto, M., Hata, K., Taniguchi, J., Moriya, H., Fujitani, M., Kubo, T. and Yamashita, T. (2006) Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats. Exp. Neurol. 200, 392-397. Hiraga, A., Kuwabara, S., Douya, H., Kanai, K., Fujitani, M., Taniguchi, J., Arai, K., Mori, M., Hattori, T., and Yamashita, T. (2006) Rho-kinase inhibition enhances axonal regeneration and functional recovery after peripheral nerve injury. J. Peripher. Nerv. Syst. 11, 217-224. Hata, K., Kubo, T., Yamaguchi, A. and Yamashita, T. (2006) Signaling mechanisms of axon growth inhibition. Drug News Perspect. 19, 541-547. Maeda, Y., Fujimura, L., O-Wang, J., Hatano, M., Sakamoto, A., Arima, M.,Ebara, M., Ino, H., Yamashita, T., Saisho, H. and Tokuhisa, T. (2006) Role of Clast1 in development of cerebellar granule cells. Mol. Brain Res. 1104,18-26. Sato, T., Doi, K., Taniguchi, M., Yamashita, T., Kubo, T. and Tohyama, M.(2006) Progressive hearing loss in mice carrying a mutation in the p75 gene. Brain Res.1091, 224-234. Doya, H., Ito, T., Hata, K., Fujitani, M., Ohtori, S., Saito-Watanabe, T.,Moriya, H., Takahashi, K., Kubo, T. and Yamashita, T. (2006) Induction ofrepulsive guidance molecule in neurons following sciatic nerve injury. J.Chem. Neuroanat. 32, 74-77. Saito-Watanabe, T., Ohtori, S., Koda, M., Aoki, Y., Doya, H., Shirasawa, H., Yamazaki, M., Moriya, H., Takahashi, K. and Yamashita, T. (2006) Adenoviral Gene Transfer in the Peripheral Nervous System. J. Orthopaedic Sci. 11,64-69

2005

Yamagishi, S., Fujitani, M., Hata, K., Kitajo, K., Mimura, F., Abe, H. and Yamashita, T. (2005) Wallerian degeneration involves Rho/Rho-kinase signaling. J. Biol. Chem. 280, 20384-20388. Yamashita, T., Fujitani, M., Yamagishi, S., Hata, K. and Mimura, F. (2005) Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol. Neurobiol. 32, 105-112. Fujitani, M., Kawai, H., Proia, R.L., Kashiwagi, A., Yasuda, H. and Yamashita, T. (2005) Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction. J. Neurochem. 94, 15-21. Fujitani, M., Honda, A., Hata, K., Yamagishi, S., Tohyama, M. and Yamashita, T. (corresponding author) (2005) Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochem. Biophys. Res. Commun. 327, 150-154. Doya, H., Ohtori, S., Fujitani, M., Saito, T., Hata, K., Ino, H., Takahashi, K., Moriya, H. and Yamashita, T. (corresponding author) (2005) c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochem. Biophys. Res. Commun. 335, 132-138. Doya, H., Ohtori, S., Takahashi, Ka., Aoki, Y., Ino, H., Takahashi, Y., Moriya, H. and Yamashita, T. (2005) ERK MAP kinase activation in the dorsal root ganglion (DRG) and the spinal cord following DRG injury in rats. Spine 30, 2252-2256. Yamashita, T., Fujitani, M., Hata, K., Mimura, F. and Taniguchi, J. (2005) Rho/Rho-kinase as potential therapeutic targets for CNS injury. Gene Therapy and Molecular Biology 9, 265-268. Yamashita, T., Fujitani, M., Hata, K., Mimura, F. and Yamagishi, S. (2005) Diverse functions of the p75 neurotrophin receptor. Anat. Sci. Int. 80, 37-41.

2004

Hasegawa, Y., Fujitani, M., Hata, K., Tohyama, M., Yamagishi, S. and Yamashita, T. (2004) Promotion of axon regeneration by MAG and Nogo through divergent signals downstream of Gi/G. J. Neurosci. 24, 6826-6832. Hasegawa, Y.,Yamagishi, S.,Fujitani, M. and Yamashita, T. p75 neurotrophin receptor signaling in the nervous system. Biotech. Annual Review 10, 123-149. Madura, T., Yamashita, T. (corresponding author), Kubo, T., Fujitani, M., Hosokawa, K. and Tohyama, M. (2004) Activation of Rho in the injured axons following spinal cord injury. EMBO Reports 5, 412-417. Aoki, M., Yamashita, T. (corresponding author) and Tohyama, M. (2004) EphA receptors direct the differentiation of mammalian neural precursor cells through Ras/MAPK pathway. J. Biol. Chem. 279, 32643-32650. Fujitani, M., Yamagishi, S., Che, Y.-H., Hata, K., Kubo, T., Ino, H., Tohyama, M. and Yamashita, T. (corresponding author). (2004) P311 accelerates nerve regeneration of the axotomized facial nerve. J. Neurochem. 91, 737-744. Mizuno, T., Yamashita, T. (corresponding author) and Tohyama, M. Chimaerins act downstream from neurotrophins in overcoming inhibition of neurite outgrowth by MAG. J. Neurochem. 91,395-403. Tanaka, H., Yamashita, T. (corresponding author), Yachi, K., Fujiwara, K., Yoshikawa, K. and Tohyama, M. (2004) Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 127, 155-164. Tsuji, L., Yamashita, T. (corresponding author), Kubo, T., Madura, T., Tanaka, H., Hosokawa, K. and Tohyama, M. (2004) A cell surface molecule containing LRR repeats and a FNIII domain, FLRT3, promotes neurite outgrowth. Biochem. Biophys. Res. Commun. 313, 1086-1091. Madura, T., Yamashita, T. (corresponding author), Tsuji, L., Hosokawa, K. and Tohyama, M. (2004) Changes in mRNA of Slit-Robo GTPase activating protein 2 following facial nerve transection. Mol. Brain Res. 123, 76-80. Ino, H. (2004) Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system. J. Histochem. Cytochem. 52, 311-323.

2003

Yamashita, T. (corresponding author) and Tohyama, M. (2003) The p75 receptor acts as a displacement factor that releases Rho from Rho GDI. Nature Neurosci. 6, 461-467. Higuchi, H., Yamashita, T. (corresponding author), Yoshikawa, H. and Tohyama, M. (2003) PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. EMBO J. 22, 1790-1800. Higuchi, H., Yamashita, T. (corresponding author), Yoshikawa, H. and Tohyama, M. (2003) Functional inhibition of the p75 receptor using a small interfering RNA. Biochem. Biophys. Res. Commun. 301, 804-809. Hosomi, S., Yamashita, T. (corresponding author), Aoki, M. and Tohyama, M. (2003) The p75 receptor is required for BDNF-induced differentiation of neural precursor cells. Biochem. Biophys. Res. Commun. 301, 1011-1015. Kasai, K., Yamashita, T. (corresponding author), Yamaguchi, A., Yoshiya, K., Kawakita, A., Tanaka, H., Sugimoto, H. and Tohyama, M. (2003) Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. Mol. Brain Res. 110, 38-44. Madura, T., Yamashita, T. (corresponding author), Kubo, T., Taniguchi, M., Kawakita, A., Hosokawa K. and Tohyama, M. Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain. Mol. Brain Res. 114, 163-167. Kawakita, A., Yamashita, T. (corresponding author), Taniguchi, M., Koyama, Y., Kubo, T., Tsuji, L. and Tohyama, M. Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain. Dev. Brain Res. 144, 181-189. Yamagishi, S. (corresponding author), Yamada, M., Koshimizu, H., Takai, S., Hatanaka, H., Takeda, K., Ichijo, H., Shimoke, K., Ikeuchi, T. Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons. J Biochem. 133, 719-24, 2003. Yamagishi, S. (corresponding author), Matsumoto, T., Yokomaku, D., Hatanaka, H., Shimoke, K., Yamada, M., Ikeuchi, T. Comparison of Inhibitory Effects of Brain-derived Neurotrophic Factor and Insulin-like Growth Factor on Low Potassium-induced Apoptosis and Activation of p38 MAPK and c-Jun in Cultured Cerebellar Granule Neurons. Mol. Brain Res. 119, 184-191.

2002

Yamashita, T. (corresponding author), Higuchi, H., and Tohyama, M. (2002) The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J. Cell Biol. 157, 565-570. Tanaka, H., Yamashita, T. (corresponding author), Asada, M., Mizutani, S., Yoshikawa, H. and Tohyama, M. (2002) Cytoplasmic p21Cip1/WAF1 regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell Biol. 158, 321-329. Kubo, T., Yamashita, T. (corresponding author), Yamaguchi, A., Sumimoto, H., Hosokawa, K. and Tohyama, M. (2002) A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J. Neurosci. 22, 8504-8513. Neumann, H., Schweigreiter, R., Yamashita, T., Rosenkrantz, K., Wekerle, H. and Barde, Y.A. (2002) Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho dependent mechanism. J. Neurosci. 22, 854-862. Yamaguchi, A., Taniguchi, M., Hori, O., Ogawa, S., Tojo, N., Matsuoka, N., Miyake, S., Kasai, K., Sugimoto, H., Tamatani, M., Yamashita, T. and Tohyama, M. (2002) Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia. J. Biol. Chem. 277, 623-629. Kubo, T., Yamashita, T. (corresponding author), Yamaguchi, A., Hosokawa, K. and Tohyama, M. (2002) Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays. J. Neurochem. 82, 1129-1136. Miyake,S., Yamashita, T (corresponding author), Taniguhi, M., Tamatani, M., Sato, K. and Tohyama, M. (2002) Identification and characterization of a novel mitochondrial tricarboxylate carrier. Biochem. Biophys. Res. Commun. 295,463-468 Miyake, S., Yamashita, T. (corresponding author),Taniguchi, M, Tamatani, M., Sato, K., Kawai,Y., Senba, E., Mitsuda, N., Hori, O., Yamaguchi, A. and Tohyama, M. (2002) Expresson of mitochondrial tricaarboxylate carrier TCC mRNA and protein in the rat brain. Mol. Brain Res. 100,67-73. Che, Y.H., Yamashita, T. (corresponding author), Higuchi, H. and Tohyama, M. (2002) Changes in mRNA for choline transporter-like protein following facial nerve transection. Mol. Brain Res. 101,122-125. Che, Y.H., Yamashita, T. (corresponding author) and Tohyama, M. (2002) Changes in mRNA for VAMPs following facial nerve transection. J. Chem. Neuroanat. 24, 147-152. Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., Yokomaku, D., Yamada, M., Hatanaka, H. (2002) Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. J Biol Chem. , 277, 6520-9, 2002.