研究Research

研究業績一覧

英文

感染症の診断・治療から予防、抗菌薬の適正使用まで。臨床研究、全国規模のデータ解析、基礎研究を通じて、感染症診療の向上に取り組んでいます。

2025年

  • First case of nosocomial transmission of severe fever with thrombocytopenia syndrome in Japan.
    Kiyotoki S, Kurotaka R, Tokunaga Y, Takahashi T, Shimojima M, Yoshikawa T, Ebihara H, Sada RM, Kutsuna S.
    Int J Infect Dis. 2025;160:108057. 論文を読む ↗

    日本でのSFTS院内伝播事例を報告し、医療現場の感染対策を検討した研究。

  • Research to evaluate safety and impact of long COVID intervention with Ensitrelvir for National Cohort (RESILIENCE Study).
    Konishi K, Yamamoto S, Sada RM, Asano K, Onozuka D, Tanaka S, Miyazawa S, Kinoshita M, Kutsuna S.
    PLoS One. 2025;20(11):e0335609. 論文を読む ↗

    エンシトレルビルと罹患後症状の関係を評価するRESILIENCE研究。

  • Epidemiology and Prognostic Factors of Herpes Simplex Virus Encephalitis in Japan: A Nationwide Database Study.
    Kutsuna S, Ohbe H, Kimura Y, Shinmoto K, Matsuo Y, Matsui H, Fushimi K, Yasunaga H.
    J Epidemiol. 2025. Online ahead of print. 論文を読む ↗

    全国データベースを用いて単純ヘルペス脳炎の疫学と予後因子を検討。

  • Association between early initiation of anti-herpesvirus therapy and outcomes in herpesvirus encephalitis.
    Kutsuna S, Ohbe H, Kimura Y, Shinmoto K, Matsuo Y, Matsui H, Fushimi K, Yasunaga H.
    Int J Infect Dis. 2025;159:107997. 論文を読む ↗

    ヘルペスウイルス脳炎での治療開始時期と転帰の関連を検討。

  • Pulmonary Infection Due to Trametes elegans and Peniophora incarnata.
    Matsuo H, Fujiwara K, Niki M, Kutsuna S.
    Open Forum Infect Dis. 2025;12(10):ofaf575. 論文を読む ↗

    まれな担子菌による肺感染症を報告。

  • Serial computed tomography imaging of splenic infarction associated with Epstein-Barr virus infection.
    Yamamoto T, Sada RM, Yamamoto S, Hosokawa N, Kutsuna S.
    IDCases. 2025;40:e02271. 論文を読む ↗

    EBウイルス感染に伴う脾梗塞の画像経過を提示。

  • Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study.
    Motoyoshi T, Ogawa T, Fukushima K, Kutsuna S, Schermann H, Fushimi K, Yoshii T.
    Int J Infect Dis. 2025;153:107767. 論文を読む ↗

    全国入院データから化膿性脊椎椎間板炎の季節性を検討。

  • Elevated risk of severe COVID-19 outcomes among underweight patients in Japan: A national registry-based study.
    Matsushita Y, Yokoyama T, Hayakawa K, Saito S, Matsunaga N, Terada M, Suzuki S, Morioka S, Kutsuna S, Hara H, Kimura A, Ohmagari N.
    Glob Health Med. 2025;7(4):340–346. 論文を読む ↗

    全国レジストリを用いて低体重とCOVID-19の重症転帰との関連を検討。

  • Functional prognosis of older adults with tetanus in Japan: a single-center retrospective study.
    Yamamoto T, Sada RM, Yamamoto S, Osawa R, Hosokawa N, Kutsuna S.
    BMC Infect Dis. 2025;25:1433. 論文を読む ↗

    高齢の破傷風患者の機能予後を検討した後ろ向き研究。

  • Opsoclonus-myoclonus-ataxia Syndrome in an ART-naïve Patient With CSF/Plasma HIV-1 RNA Discordance.
    Matsuo H, Yonekura K, Kutsuna S.
    Open Forum Infect Dis. 2025;12(9):ofaf517. 論文を読む ↗

    未治療HIV感染者に生じた神経症候群と髄液・血漿のウイルス量の乖離を報告。

  • Evaluating ChatGPT's responses to vaccine-related questions: the impact of question framing on content and quality.
    Kusama Y, Kutsuna S.
    Transl Pediatr. 2025;14(11):3020–3028. 論文を読む ↗

    質問の表現がワクチンに関するChatGPTの回答内容と質に与える影響を評価。

  • Impact of COVID-19 on the awareness and interest in infectious disease specialization among Japanese medical students.
    Kamada N, Hagiya H, Kutsuna S.
    PLoS One. 2025;20(9):e0329451. 論文を読む ↗

    COVID-19流行と医学生の感染症専門領域への関心を調査。

  • Effect of Empirical Antimicrobial Therapy of Piperacillin-tazobactam Versus Carbapenems on Mortality for Patients with Sepsis from Nursing Homes.
    Shimada Y, Ohbe H, Kutsuna S, Kosaka S, Matsui H, Yasunaga H.
    Intern Med. 2025;64(12):1820–1827. 論文を読む ↗

    介護施設から入院した敗血症患者の経験的抗菌薬治療と死亡率を比較。

  • The Majority of Bacillus subtilis Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto.
    Sada RM, Yamamoto G, Hamaguchi S, Kuroda E, Okura A, Cai M, Nakanishi K, Abe N, Yamamoto S, Kutsuna S.
    Open Forum Infect Dis. 2025;12(9):ofaf574. 論文を読む ↗

    血液培養から分離された枯草菌と納豆由来菌株の関連を検討。

  • Symptoms of post COVID-19 condition and diseases/conditions diagnosed after COVID-19 in Japanese patients: A real-world study using a claims database.
    Kutsuna S, Tajima R, Ito G, Komeda T, Miyauchi H, Kitanishi Y.
    J Infect Chemother. 2025;31(2):102540. 論文を読む ↗

    レセプトデータからCOVID-19後の症状や新たな診断を調査。

  • Exploring the efficacy of routine antimicrobial therapy in severe fever with thrombocytopenia syndrome.
    Kutsuna S, Ohbe H, Matsui H, Yasunaga H.
    J Infect Chemother. 2025;31(1):102457. 論文を読む ↗

    SFTS患者への抗菌薬投与の有効性を検討。

  • Hemorrhagic shock and encephalopathy syndrome with hyper-inflammation and elevation of IL-6 and GDF-15 following COVID-19: A case report.
    Yokono Y, Ebihara T, Onishi S, Takahashi Y, Matsumoto H, Shimizu K, Kutsuna S, Oda J.
    IDCases. 2025;42:e02390. 論文を読む ↗

    COVID-19後に高度の炎症を伴う出血性ショック脳症症候群を呈した症例を報告。

  • Fibular subperiosteal abscess without osteomyelitis.
    Matsumaru N, Atsumi Y, Kusama Y, Ihara T, Kamimura K, Maihara T.
    Pediatr Int. 2025;67(1):e70118. 論文を読む ↗

    骨髄炎を伴わない腓骨骨膜下膿瘍の症例を提示。

  • Factors associated with using penicillins as the first-choice antimicrobial among dentists in Japan: a national cross-sectional study.
    Koizumi R, Ishikane M, Kusama Y, Tsuzuki S, Asai Y, Shimada Y, Tanaka C, Kaneko A, Ohmagari N.
    Antimicrob Steward Healthc Epidemiol. 2025;5(1):e156. 論文を読む ↗

    歯科医師によるペニシリン系薬の第一選択と関連する要因を全国調査。

  • A Case of Recurrent Bacteremic Cellulitis Caused by Citrobacter koseri.
    Naito Y, Kusama Y, Terada H.
    Cureus. 2025;17(8):e89800. 論文を読む ↗

    Citrobacter koseriによる菌血症を伴う反復性蜂窩織炎を報告。

  • Current management and awareness of hepatitis coinfection in HIV care: A single-center retrospective study in Japan.
    Konishi K, Matsuo H, Shirano M.
    J Infect Chemother. 2025;31(2):102557. 論文を読む ↗

    HIV診療における肝炎重複感染の管理状況を検討。

  • Effectiveness of ampicillin/sulbactam versus ceftriaxone for the initial treatment of community-acquired pneumonia in older adults: a target trial emulation study.
    Yamamoto S, Shiroshita A, Kataoka Y, Someko H.
    Open Forum Infect Dis. 2025;ofaf133. 論文を読む ↗

    高齢者の市中肺炎に対する初期抗菌薬治療を、標的試験エミュレーションで比較。

2024年

  • Travel-associated sexually transmitted infections in Japan: An observational study using imported infectious disease registry data
    Konishi K.; Kutsuna S.; Yamamoto K.; Nomoto H.: Shirano M,.;Yamato M.;Yoshimura Y.; Sakamoto N,.;Nagasaka A .;Ohmagari  N.
    Global Health & Medicine.2024;6(4), pp. 264–267
  • COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production
    Nakamoto T.; Iwamoto N.; Oshiro Y.; Inamura N.; Nemoto T.; Ide S.; Nakamura K.; Nomoto H.; Akiyama Y.; Suzuki T.; Miyazato Y.; Suzuki M.; Suzuki K.; Kimura M.; Saito S.; Kutsuna S.; Ohmagari N.
    BMC Infectious Diseases.2024;24(1), 1197
  • Long-acting antiretroviral therapy effectiveness and patient satisfaction using patient questionnaires: data from a real-world setting
    Konishi K.; Onozuka D.; Okubo M.; Kasamatsu Y.; Kutsuna S.; Shirano M.
    BMC Infectious Diseases.2024;24(1), 979
  • A MULTICENTER, RANDOMIZED, OPEN-LABEL, PLACEBO-CONTROLLED CLINICAL TRIAL OF THE EFFECT OF CETYLPYRIDINIUM CHLORIDE (CPC) MOUTHWASH AND ON-DEMAND AQUEOUS CHLORINE DIOXIDE MOUTHWASH ON SARS-COV-2 VIRAL TITER IN PATIENTS WITH MILD COVID-19
    Onozuka D.; Konishi K.; Takatera S.; Osaki M.; Sumiyoshi S.; Takahasshi Y.; Hamaguchi S.; Imoto Y.; Kutsuna S.
    Journal of Evidence-Based Dental Practice.2024;24(4), 102040
  • Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids
    Kuwano T.; Kanno T.; Tobiume M.; Hirata Y.; Katano H.; Koga M.; Nagai H.; Tsutsumi T.; Yoshikawa N.; Yotsuyanagi H.; Kutsuna S.; Miyazato Y.; Kinoshita-Iwamoto N.; Ohmagari N.; Kobayashi T.;et al.
    Scientific Reports.2024;14(1), 26057
  • Successful treatment of Staphylococcus argenteus sequence type 2198 uncomplicated bacteremia with a 2-week antibiotic course
    Okumura N.; Kutsuna S.; Tsukada A.; Mezaki K.; Nagashima M.; Ohmagari N.
    IJID Regions.2024;13, 100443
  • Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial
    Onozuka D.; Takatera S.; Matsuo H.; Yoshida H.; Hamaguchi S.; Yamamoto S.; Sada R.M.; Suzuki K.; Konishi K.; Kutsuna S.
    BMC Oral Health.2024;24(1), 491
  • Epidemiological Analysis of Legionella Pneumonia in Japan: A National Inpatient Database Study
    Kutsuna S.; Ohbe H.; Kanda N.; Matsui H.;Yasunaga H.
    Journal of epidemiology.2024;34(8), pp. 365–371
  • Association between post-COVID-19 conditions and male semen quality in Japan: A descriptive investigation
    Maruki T.; Morioka S.; Miyazato Y.; Tsuzuki S.; Takezawa K.; Kuribayashi S.; Kutsuna S.; Ohmagari N.; Fukuhara S.
    Journal of Infection and Chemotherapy.2024;30(11), pp. 1194–1196
  • Peritonsillar abscess associated with Helicobacter cinaedi bacteremia: A case report
    Harada T.; Nakanishi T.; Kutsuna S.;Nakai M.
    IDCases.2024;36, e01975
  • An observational study to identify causative factors for not using hydroxychloroquine in systemic lupus erythematosus
    Manabe A.; Sada R.M.; Miyake H.; Akebo H.; Tsugihashi Y.; Hatta K.
    Scientific Reports.2024;14(1), 7750
  • Reviving Sternheimer stain: A single-center retrospective study to detect the diagnostic utility of urinary tract infections in the emergency department
    Nagatomi H.; Sada R.M.; Abe N.; Miyake H.; Akebo H.
    Journal of Infection and Chemotherapy.2024;30(8), pp. 768–772
  • Successful treatment of streptococcal toxic shock syndrome complicated by primary peritonitis and bilateral empyema in a healthy young woman: Identification of uncommon clone emm103 and novel sequence type 1363
    Sakaguchi Y.M.; Murakami K.; Akebo H.; Sada R.M.; Abe N.; Maeda T.; Goto M.; Takahashi T.; Takahashi Y.; Kashihara E.; Shim J.; Miyake H.; Hatta K.
    IDCases.2024;35, e01927
  • Can the “Access” percentage assess the antibiotic use appropriateness?
    Kusama Y.
    Journal of Infection and Chemotherapy;2024;30(8), pp. 824
  • First Pediatric Case of Endocarditis Caused by Moraxella nonliquefaciens : Importance of Molecular Diagnosis
    Yoshitake S.; Kusama Y.; Shiomi F.; Nakahashi T.; Toyota N.; Yoshizawa K.; Ito Y.; Kamimura K.
    The Pediatric infectious disease journal.2024;43(8), pp. e289
  • Polypharmacy prevalence and associated factors in patients with systemic lupus erythematosus: A single-centre, cross-sectional study
    Miyake H.; Sada R.M.; Akebo H.; Tsugihashi Y.; Hatta K.
    Modern Rheumatology.2024;34(1), pp. 106–112
  • Using novel micropore technology combined with artificial intelligence to differentiate Staphylococcus aureus and Staphylococcus epidermidis
    Morimura A.; Taniguchi M.; Takei H.;Sakamoto O.; Naono N.; Akeda Y.; Onozuka D.; Yoshimura J.; Tomono K.; Kutsuna S.;Hamaguchi S.
    Scientific Reports.2024;14(1), 6994
  • Analysis of the effectiveness of combination antimicrobial therapy for Legionnaires' disease: A nationwide inpatient database study
    Kutsuna S.; Ohbe H.; Matsui H.; Yasunaga H.
    International Journal of Infectious Diseases.2024;142, 106965
  • Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan
    Sada R.M.; Matsuo H.; Motooka D.; Kutsuna S.; Hamaguchi S.; Yamamoto G.; Ueda A.
    Emerging Infectious Diseases.2024;30(4), pp. 665–671
  • Analysis of Differences in Characteristics of High-Risk Endemic Areas for Contracting Japanese Spotted Fever, Tsutsugamushi Disease, and Severe Fever With Thrombocytopenia Syndrome
    Ogawa T.; Tsuzuki S.; Ohbe H.; Matsui H.; Fushimi K.; Yasunaga H.; Kutsuna S.
    Open Forum Infectious Diseases.2024;11(2), ofae025
  • Cross-sectional surveillance study of long COVID in Toyonaka city, Osaka prefecture, Japan
    Kutsuna S.; Onozuka D.; Asano K.; Matsunami K.; Matsuoka T.
    Journal of Infection and Chemotherapy.2024;30(6), pp. 511–515
  • Pott's Puffy Tumor Initially Presenting as Eyelid Swelling without Typical Forehead Swelling: A Case Report.
    Hiroshi Yamamoto, Hirokazu Kuroda, Takashi Hiroi, Toshikazu Hasuike, Asako Doi, Hiroaki Nishioka.
    Intern Med. 2024 Nov 21. Online ahead of print. 論文を読む ↗

    典型的な前額部腫脹を伴わず、眼瞼腫脹で発症した症例を報告。

  • Caution on Interpretation of Noninferiority Trial Results.
    Shungo Yamamoto.
    Am J Gastroenterol. 2024;119(7):1438.

    非劣性試験の結果を解釈する際の注意点を論じた論考。

  • Ruthenibacterium lactatiformans isolated from a human blood culture: a first report.
    Shougen Sumiyoshi, Shigeto Hamaguchi, Keigo Kimura, Katsuyuki Negishi, Koshi Ninomiya, Manabu Sasaki, Satoshi Kutsuna.
    BMC Infect Dis. 2024;24(1):699.

    ヒト血液培養からのRuthenibacterium lactatiformans分離を報告。

  • Accuracy of odor-based microorganism identification by microbiological technologists with different years of experience: A cross-sectional study.
    Tatsuya Fujihara, Hiroo Matsuo, Go Yamamoto, Atsuko Sunada, Shigeto Hamaguchi, Daisuke Onozuka, Satoshi Kutsuna.
    Heliyon. 2024;10(16):e36573.

    微生物検査技師の経験年数と、においによる菌種識別の精度を検討。

  • First case report of cefmetazole-induced disulfiram-like reaction.
    Toshiyuki Nakanishi, Taku Harada, Mori Nakai, Satoshi Kutsuna.
    IDCases. 2024;37:e02056.

    セフメタゾールによるジスルフィラム様反応の症例を報告。

  • Timing and prediction of secondary bacteremia in patients with COVID-19: A retrospective cohort study.
    Aoi Yogo, Shungo Yamamoto, Kentaro Tochitani.
    J Gen Fam Med. 2024;25(4):206–213.

    COVID-19患者における二次性菌血症の発症時期と予測因子を検討。

  • Caution when incorporating observational studies into a meta-analysis.
    Shungo Yamamoto.
    J Infect Chemother. 2024;30(7):672.

    メタ解析への観察研究の組み入れに関する方法論的な注意点。

  • Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption.
    Sayaka Shizukuishi, Michinaga Ogawa, Eisuke Kuroda, Shigeto Hamaguchi, Chisato Sakuma, Soichiro Kakuta, Isei Tanida, Yasuo Uchiyama, Yukihiro Akeda, Akihide Ryo, Makoto Ohnishi.
    Cell Rep. 2024;43(3):113962.

    肺炎球菌のシアリダーゼと膜障害・菌の生存機構の関係を検討。

  • Brief communication: body composition and hidden obesity in people living with HIV on antiretroviral therapy.
    K Konishi, H Nakagawa, T Asaoka, Y Kasamatsu, T Goto, M Shirano.
    AIDS Res Ther. 2024;21(1):12.

    抗レトロウイルス療法中のHIV感染者の体組成と隠れ肥満を検討。

  • Contamination rate of rare bacterial species detected by MALDI-TOFMS: a retrospective cohort study.
    Shougen Sumiyoshi, Kazuaki Aoki, Hirofumi Motobayashi, Aoi Yogo, Kentaro Tochitani.
    Diagn Microbiol Infect Dis. 2024;108(1):116110.

    MALDI-TOF MSで検出されたまれな菌種の汚染率を検討。

  • Possibility of hypoalbuminemia itself as a risk for clinical failure.
    Shougen Sumiyoshi, Shungo Yamamoto.
    Antimicrob Agents Chemother. 2024;68(6):e0036724.

    低アルブミン血症と治療不成功との関係を考察。

2023年

  • Efficacy and Safety of Cefmetazole for Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales vs Carbapenems: A Retrospective Study
    Kashihara E.; Sada R.M.; Tsugihashi Y.; Obayashi H.; Nakamura A.; Abe N.; Miyake H.; Akebo H.
    Open Forum Infectious Diseases. 2023;10(10), ofad502
  • Prevalence and factors associated with polypharmacy among patients with rheumatoid arthritis: a single-centre, cross-sectional study
    Miyake H.; Sada R.M.; Akebo H.; Tsugihashi Y.; Hatta K.
    Clinical Rheumatology. 2023;42(9), pp. 2287–2295
  • Factors and Reasons for Non-vaccination among Patients with Systemic Lupus Erythematosus: A Single-centre, Cross-sectional Study
    Miyake H.; Sada R.M.; Manabe A.; Tsugihashi Y.; Hatta K.
    Internal Medicine. 2023;62(17), pp. 2483–2491
  • Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci
    Yokota C.; Fujimoto K.; Yamakawa N.; Kono M.; Miyaoka D.; Shimohigoshi M.; Uematsu M.; Watanabe M.; Kamei Y.; Sugimoto A.; Kawasaki N.; Yabuno T.; Okamura T.; Kuroda E.; Hamaguchi S. et al.
    Inflammation and Regeneration.2023;43(1), 55
  • Establishment of a modified opsonophagocytic killing assay for anti-pneumococcal surface protein A antibody
    Kuroda E.; Koizumi Y.; Piao Z.; Nakayama H.; Tomono K.; Oishi K.; Hamaguchi S.; Akeda Y.
    Journal of Microbiological Methods.2023; 212, 106804
  • Negative effects of pre-admission screening with simplified multiplex PCR
    Suzuki Y.; Kusama Y.; Ito Y.
    Pediatrics International.2023;65(1), e15629
  • Protocol for a Randomized, Open-Label Clinical Trial on the Effect of Mouthwash on Salivary SARS-CoV-2 Load
    Konishi K.; Onozuka D.; Takatera S.; Matsuo H.; Yoshida H.; Hamaguchi S.; Yamamoto S.; Sada R.M.; Suzuki K.; Kutsuna S.
    Life.2023;13(12), 2312
  • Trends of participants in convalescent plasma donation for COVID-19 in Japan as the pandemic evolved
    Suzuki T., Asai Y., Takahashi K., Sanada M., Shimanishi Y., Terada M., Sato L., Inada M., Yamada G., Akiyama Y., Oshiro Y., Shiratori K., Togano T., Takamatsu Y., Kenji M., Matsunaga A., Ishizaka Y.,  Kutsuna S., et al.
    Heliyon.2023;9(10), e20568
  • Evaluation of potential rabies exposure among Japanese international travelers: A retrospective descriptive study
    Nomoto H., Yamamoto K., Kutsuna S., Asai Y., Kasamatsu Y., Shirano M., Sahara T., et al.
    PLoS ONE.2023;18(8 AUGUST), e0287838
  • Aneurysm Infection Caused by Desulfovibrio desulfuricans
    Fujihara T., Kimura K., Matsuo H., Sada R.M., Hamaguchi S., Yamamoto G., Yamakura T., Kutsuna S.
    Emerging Infectious Diseases.2023;29(8), pp. 1680–1681
  • Evaluation Antibacterial and Bactericidal Properties of Si Nanopillars Array Against Antimicrobial Resistant (AMR) Bacteria
    Yanagisawa Y., Yamamoto G., Hamaguchi S., Shimizu T., Shingubara S., Kutsuna S., Ito T.
    Proceedings of the IEEE Conference on Nanotechnology.2023;July, pp. 1014–1017
  • The safety of plasma apheresis from donors recovering from COVID-19 infection in Japan
    Kamo-Imai A., Togano T., Sato M., Kawakami Y., Inaba K., Shimazu H., Igarashi S., Tanaka K., Terada M., Kinoshita-Iwamoto N., Saito S., Kutsuna S., et al.
    Transfusion and Apheresis Science.2023;62(3), 103687
  • Epidemiology of post-COVID conditions beyond 1 year: a cross-sectional study
    Morioka S., Tsuzuki S., Maruki T., Terada M., Miyazato Y., Kutsuna S., Saito S., Shimanishi Y., et al.
    Public Health.2023;216, pp. 39–44
  • Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial
    Saito S., Kutsuna S., Akifumi I., Hase R., Oda R., Terada J., Shimizu Y., Uemura Y., Takamatsu Y., et al.
    Journal of Infection and Chemotherapy.2023;29(9), pp. 869–874
  • Nasopharyngeal SARS-CoV-2 may not be dispersed by a high-flow nasal cannula
    Suzuki T., Morioka S., Yamamoto K., Saito S., Iida S., Teruya K., Takasaki J., Hojo M., Kutsuna S., et al.
    Scientific Reports.2023;13(1), 2669
  • Comparison of the clinical characteristics and outcomes of Japanese patients with COVID-19 treated in primary, secondary, and tertiary care facilities
    Tomidokoro D., Asai Y., Hayakawa K., Kutsuna S., Terada M., Sugiura W., Ohmagari N., Hiroi Y.
    Journal of Infection and Chemotherapy.2023;29(3), pp. 302–308
  • Deprescribing antacids after the diagnosis of Clostridioides difficile infection: A single-center observational study
    Okamoto K., Harada T., Kosaka S., Kutsuna S.
    Journal of Infection and Chemotherapy.2023;29(2), pp. 232–234
  • Steroid pulse therapy for severe fever with thrombocytopenia syndrome patients may not improve prognosis: Retrospective analysis with overlap weighting using a national inpatient database
    Kutsuna S., Ohbe H., Matsui H., Yasunaga H.
    Journal of Infection and Chemotherapy.2023;29(5), pp. 490–494
  • Nationwide Descriptive Epidemiological Study of Patients with COVID-19 Evacuated from Wuhan, China to Japan from January to February, 2020
    Nomoto H., Ishikane M., Gu Y., Yamamuro R., Osawa R., Hosokawa N., Sahara T., Nakamura-Uchiyama F., Fukushima K., Sekiya N., Imamura A., Fujikura Y., Kawana A., Nagata K., Tamura K., Kutsuna S., Ohmagari N.
    Japanese Journal of Infectious Diseases.2023;76(1), pp. 20–26
  • Preserved SARS-CoV-2 neutralizing IgG activity of in-house manufactured COVID-19 convalescent plasma
    Inada M., Togano T., Terada M., Shiratori K., Tsuzuki S., Takamatsu Y., Saito S., Hangaishi A., Morioka S., Kutsuna S., Maeda K., Mitsuya H., Ohmagari N.
    Transfusion and Apheresis Science.2023;62(3), 103638
  • Caveats for Validating the Diagnostic Accuracy of Diagnostic or Classification Criteria for Infective Endocarditis.
    Shungo Yamamoto.
    Clin Infect Dis. 2023;77(8):1216.

    感染性心内膜炎の診断・分類基準の精度検証における注意点。

  • Prehospital shock index predicts 24-h mortality in trauma patients with a normal shock index upon emergency department arrival.
    Yoshie Yamada, Sayaka Shimizu, Shungo Yamamoto, Yoshinori Matsuoka, Yusuke Tsutsumi, Asuka Tsuchiya, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa, Shunichi Fukuhara, Yosuke Yamamoto.
    Am J Emerg Med. 2023;70:101–108.

    外傷患者の病院前ショックインデックスと24時間死亡との関連を検討。

  • Report of HKU-1 coronavirus nosocomial cluster in a city hospital in Japan during the coronavirus disease 2019 (COVID-19) pandemic.
    Aoi Yogo, Shougen Sumiyoshi, Kazuaki Aoki, Hirofumi Motobayashi, Kentaro Tochitani, Shungo Yamamoto, Tsunehiro Shimizu.
    Antimicrob Steward Healthc Epidemiol. 2023;3(1):e18.

    COVID-19流行中に生じた季節性コロナウイルスHKU-1の院内集団発生を報告。

  • Analysis of Concentrated COVID-19 Outbreaks in Elderly Facilities in Suita City, Osaka Prefecture, Japan.
    Toshiyuki Shibata, Sawa Okano, Daisuke Onozuka, Etsuko Ohta, Satoshi Kutsuna.
    Int J Environ Res Public Health. 2023;20(20):6926.

    大阪府吹田市の高齢者施設で発生したCOVID-19集団感染を分析。

  • Fever in a heart transplant recipient related to remaining LVAD component.
    Tatsuya Fujihara, Shungo Yamamoto, Daisuke Sakamoto, Satoshi Kutsuna.
    IDCases. 2023;33:e01822.

    心移植後に残存した左室補助人工心臓の部品に関連する発熱症例を報告。

  • Neutralization activity of IgG antibody in COVID‑19‑convalescent plasma against SARS-CoV-2 variants.
    Kiyoto Tsuchiya, Kenji Maeda, Kouki Matsuda, Yuki Takamatsu, Noriko Kinoshita, Satoshi Kutsuna, Tsunefusa Hayashida, Hiroyuki Gatanaga, Norio Ohmagari, Shinichi Oka, Hiroaki Mitsuya.
    Sci Rep. 2023;13(1):1263.

    COVID-19回復者血漿のIgG抗体が変異株に示す中和活性を評価。

  • Analysis of cross-reactivity among flaviviruses using sera of patients with dengue showed the importance of neutralization tests with paired serum samples for the correct interpretations of serological test results for dengue.
    Takahiro Maeki, Shigeru Tajima, Naokatsu Ando, Yuji Wakimoto, Kayoko Hayakawa, Satoshi Kutsuna, Fumihiro Kato, Satoshi Taniguchi, Eri Nakayama, Chang-Kweng Lim, Masayuki Saijo.
    J Infect Chemother. 2023;29(5):469–474.

    デング患者血清でフラビウイルス間の交差反応と中和試験による評価を検討。

  • We Should Pay More Attention to Sex Differences to Predict the Risk of Severe COVID-19: Men Have the Same Risk of Worse Prognosis as Women More Than 10 Years Older.
    Yumi Matsushita, Tetsuji Yokoyama, Kayoko Hayakawa, Nobuaki Matsunaga, Hiroshi Ohtsu, Sho Saito, Mari Terada, Setsuko Suzuki, Shinichiro Morioka, Satoshi Kutsuna, Shinya Tsuzuki, Hisao Hara, Akio Kimura, Norio Ohmagari.
    J Epidemiol. 2023;33(1):38–44.

    COVID-19の重症化リスクにおける性別と年齢の関係を検討。

  • Establishment and clinical application of SARS-CoV-2 catch column.
    Yoshitaka Isaka, Taku Yoshiya, Chikako Ono, Akinori Uchiyama, Haruhiko Hirata, Shigeto Hamaguchi, Satoshi Kutsuna, Yoshitsugu Takabatake, Ryotaro Saita, Tomomi Yamada, Atsushi Takahashi, Masaya Yamato, Yukie Nohara, Shugo Tsuda, Itsuki Anzai, Tomonori Kimura, Yoshito Takeda, Kazunori Tomono, Yoshiharu Matsuura.
    Clin Exp Nephrol. 2023;27(3):279–287.

    SARS-CoV-2を捕捉するカラムの開発と臨床応用を検討。

2022年

  • Bacillus subtilis variant natto Bacteremia of Gastrointestinal Origin, Japan.
    Tanaka I, Kutsuna S, Ohkusu M, Kato T, Miyashita M, Moriya A, et al.
    Emerging infectious diseases. 2022;28(8):1718-1719
  • Cardiovascular complications of hospitalized patients with coronavirus disease 2019 in a Japanese registry in 2020
    Hiroi Y, Ohtsu H, Uemura Y, Hayakawa K, Asai Y, Kutsuna S, et al.
     Circulation Journal. 2022;86(3):464-471
  • Catheter-related bloodstream infection caused by Tsukamurella ocularis: A case report
    Kawashima A, Kutsuna S, Shimomura A, Suzuki T, Nakamoto T, Ando H, et al.
     Journal of Infection and Chemotherapy. 2022;28(3):434-436
  • Clinical performance testing of the automated haematology analyzer XN-31 prototype using whole blood samples from patients with imported malaria in Japan
    Komaki-Yasuda K, Kutsuna S, Kawaguchi M, Kamei M, Uchihashi K, Nakamura K, et al.
    Malaria journal. 2022;21(1)
  • Delayed Tetracycline Initiation Increases Mortality Risk in Patients With Japanese Spotted Fever: Retrospective Analysis Using a National Inpatient Database
    Kutsuna S, Ohbe H, Matsui H, Yasunaga H,
     Open Forum Infectious Diseases; 2022: 9(11):ofac573
  • Effectiveness of fluoroquinolone antimicrobials in addition to tetracyclines for Japanese spotted fever: A retrospective analysis using a national inpatient database
    Kutsuna S, Ohbe H, Matsui H, Yasunaga H.
     International Journal of Infectious Diseases. 2022;123:70-5
  • Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 panel, a rapid multiplex PCR method for the diagnosis of COVID-19
    Ishikane M, Unoki-Kubota H, Moriya A, Kutsuna S, Ando H, Kaburagi Y, et al.
     Journal of Infection and Chemotherapy. 2022;28(6):729-734
  • Factors associated with development and persistence of post-COVID conditions: A cross-sectional study
     Miyazato Y, Tsuzuki S, Morioka S, Terada M, Kutsuna S, Saito S, et al.
    Journal of Infection and Chemotherapy. 2022;28(9)1242-1248
  • Impact of the COVID-19 pandemic on racial and ethnic minorities in Japan
    Nomoto H, Asai Y, Hayakawa K, Matsunaga N, Kutsuna S, Kodama EN, Ohmagari N.
     Epidemiology & Infection. 2022;150:e202
  • Imported African Tick Bite Fever in Japan: A Literature Review and Report of Three Cases
    Ando N, Kutsuna S, Takaya S, Katanami Y, Ohmagari N.
    Internal Medicine. 2022;61(7):1093-1098.
  • Interleukin-6 is upregulated and may be associated with myocardial injury in some patients who have recovered from COVID-19.
     Hayama H, Ide S, Kitami Y, Hara H, Kutsuna S, Hiroi Y.
    Global health & medicine. 2022;4(1):61-3.
  • A Multi-Center, Open-Label, Randomized Controlled Trial to Evaluate the Efficacy of Convalescent Plasma Therapy for Coronavirus Disease 2019: A Trial Protocol (COVIPLA-RCT)
    Tomita N, Saito S, Terada-Hirashima J, Mikami A, Uemura Y, Kutsuna S, et al.
     Life. 2022;12(6):856.
  • Safety of convalescent plasma therapy for COVID-19 patients and analysis of viral kinetics: a single-center, open-label, single-arm, interventional study in Japan.
    Kutsuna S, Saito S, Takamatsu Y, Terada M, Togano T, Kinoshita N, et al.
    GHM Open. 2022.
  • Streptobacillus notomytis Bacteremia after Exposure to Rat Feces 
    Kawashima A, Kutsuna S, Shimomura A, Sato L, Ando H, Tanikawa T, Nagashima M, Miyoshi-Akiyama T, Inagaki T, Ohmagari N.   
     Emerging Infectious Diseases. 2022;28(4):886-888
  • Association between serum alkaline phosphatase and bacteraemia in haemodialysis outpatients: a multicentre retrospective cross-sectional study 
     Katasako A, Sasaki S, Raita Y, Yamamoto S, Tochitani K, Murakami M, Nishioka R, Fujisaki K. 
     BMJ Open. 2022 Oct 7;12(10):e058666.
  • Comparison of extraction-based and elution-based polymerase chain reaction testing, and automated and rapid antigen testing for the diagnosis of severe acute respiratory syndrome coronavirus 2.
    Yoshioka N, Deguchi M, Hagiya H, Kagita M, Tsukamoto H, Takao M, Yoshida H, Hamaguchi S, Maeda I, Hidaka Y, Tomono K.
    J Med Virol. 2022 Jul;94(7):3155-3159. doi: 10.1002/jmv.27709. Epub 2022 Mar 22.
  • Immunogenicity of SARS‐CoV‐2 vaccination in adolescents with cardiac disease
    Hayashi H,Narita J,Ishii R, Hirose M, Hashimoto K,Yamagishi Y,Ozono K, Nakagami H, Ishida H
    Pediatrics International (2022)64, e15329
  • Safety evaluation of MA-T after ingestion in mice.
    Noguchi T, Tachibana K, Inoue T,Sakai T, Tsujikawa K,Fujio Y, Yamagishi Y, Hamaguchi S, Kutsuna S, Kondoh M
    Toxicology 477 Jul: 153254

2021年

  • Catheter-related bloodstream infection caused by Tsukamurella ocularis: A case report      Kawashima A, Kutsuna S, Shimomura A, Suzuki T, Nakamoto T, Ando H, Nagashima M, Inagaki T, Ohmagari N.                                                Journal of Infection and Chemotherapy.28(3):434-436
  • Effects of message order and active participation on vaccine risk communication.
    Okuno H, Satoh H, Iitake C, Hosokawa S, Oishi K, Kikkawa T.
    Pediatr Int. 2021 Nov;63(11):1363-1368. doi: 10.1111/ped.14662. Epub 2021 Sep 30. PMID: 33599373.
  • Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection.
    Taniguchi M, Minami S, Ono C, Hamajima R, Morimura A, Hamaguchi S, Akeda Y, Kanai Y, Kobayashi T, Kamitani W, Terada Y, Suzuki K, Hatori N, Yamagishi Y, Washizu N, Takei H, Sakamoto O, Naono N, Tatematsu K, Washio T, Matsuura Y, Tomono K.
    Nat Commun. 2021 Jun 17;12(1):3726.
  • Mechanisms Underlying Pneumococcal Transmission and Factors Influencing Host-Pneumococcus Interaction: A Review.
    Morimura A, Hamaguchi S, Akeda Y, Tomono K.
    Front Cell Infect Microbiol. 2021 Apr 28;11:639450.
  • 10-Year survey on serum antibody positivity rates and titers for measles and rubella in healthcare workers; an observational study at a Japanese university hospital.
    Yoshioka N, Deguchi M, Hagiya H, Kagita M, Tsukamoto H, Takao M, Yoshida H, Hamaguchi S, Maeda I, Hidaka Y, Tomono K.
    J Infect Chemother. 2021 Sep;27(9):1295-1299.
  • Multiplex Real-Time PCR Assay for Six Major Carbapenemase Genes.
    Yoshioka N, Hagiya H, Deguchi M, Hamaguchi S, Kagita M, Nishi I, Akeda Y, Tomono K.
    Pathogens. 2021 Mar 1;10(3):276.
  • Deskilled and Rapid Drug-Resistant Gene Detection by Centrifugal Force-Assisted Thermal Convection PCR Device.
    Espulgar WV, Saito M, Takahashi K, Ushiro S, Yamamoto N, Akeda Y, Hamaguchi S, Tomono K, Tamiya E.
    Sensors (Basel). 2021 Feb 9;21(4):1225.
  • The characteristics and clinical course of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan.
    Hirayama A, Masui J, Murayama A, Fujita S, Okamoto J, Tanaka J, Hirayama T, Ohara T, Hoffmann EN, Zhang J, Kawachi H, Okuno H, Hamaguchi S, Tomono K, Asada R.
    Int J Infect Dis. 2021 Jan;102:282-284.

2020年

  • Economic impact of antimicrobial-resistant bacteria outbreaks on Japanese hospitals.
    Morii D, Tomono K, Imanaka Y.
    Am J Infect Control. 2020 Oct;48(10):1195-1199.
  • Risk for the occupational infection by cytomegalovirus among health-care workers.
    Takao M, Yoshioka N, Hagiya H, Deguchi M, Kagita M, Tsukamoto H, Hidaka Y, Tomono K, Tobe T.
    J Infect Chemother. 2020 Jul;26(7):681-684.
  • Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases.
    Ojima M, Yamamoto N, Hirose T, Hamaguchi S, Tasaki O, Kojima T, Tomono K, Ogura H, Shimazu T.
    J Intensive Care. 2020 Apr 10;8:25
  • Repeated Chest Computed Tomography Revealed Early-stage Miliary Tuberculosis.
    Okuno H, Hagiya H, Hamaguchi S, Tomono K.
    Intern Med. 2020 Feb 1;59(3):461-462.
  • Mycobacterium kansasii arthritis of the elbow in an immunocompetent patient with a suspected soft-tissue tumor.
    Okuno H, Tanaka H, Hagiya H, Yoshida H, Hamaguchi S, Hori Y, Morii E, Hamada K, Yoshikawa H, Tomono K.
    J Infect Chemother. 2020 Feb;26(2):261-264.
  • Rapid multiplex detection of the resistance genes mecA, vanA and vanB from Gram-positive cocci-positive blood cultures using a PCR-dipstick technique.
    Shanmugakani RK, Fujiya Y, Akeda Y, Hamaguchi S, Hamada S, Tomono K.
    J Med Microbiol. 2020 Feb;69(2):249-255.

邦文

  • 日本国内で開発され、米国で臨床試験が行われていない抗菌薬の用法用量に関するアンケート調査      日馬由貴,町田尚子, 松尾裕央, 山岸義晃,忽那賢志                          日本化学療法学会雑誌,2024
  • 【ミミッカー症例からいかに学ぶか】ミミッカーに騙されないための方略とは               佐田 竜一                                              日本化学療法学会雑誌,Vol.71 no.4::415-416,2023.07
  • 効果的なICTラウンド活動~継続的な評価と現場を支える活動~
    太田悦子,長田麻友子,吉田寿雄,吉岡範,小門諒平,鍋谷佳子
    環境感染誌 , Vol.36 no.4 : 196-204, 2021.