現在の位置

研究業績

2012

  • Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T. FGF23 suppresses chondrocyte proliferation in the presence of soluble a-Klotho both in vivo and in vitro. J Biol Chem. 2012 Dec. [Epub ahead of print]
  • Miura K, Namba N, Fujiwara M, Ohata Y, Ishida H, Kitaoka T, Kubota T, Hirai H, Higuchi C, Tsumaki N, Yoshikawa H, Sakai N, Michigami T, Ozono K. An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 7:e42180, 2012
  • Onodera A, Tani M, Michigami T, Yamagata M, Min KS, Tanaka K, Nakanishi T, Kimura T, Itoh N. Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo. Toxicol Lett. 212: 91-96, 2012
  • Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T. Vinculin functions as regulator of chondrogenesis. J Biol Chem. 287:15760-15775, 2012

2011

  • Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima YI, Yamazaki Y, Ozono K. Circulating Levels of Soluble {alpha}-Klotho Are Markedly Elevated in Human Umbilical Cord Blood. J Clin Endocrinol Metab. 96:E943-947, 2011
  • Kawai M, Breggia AC, Demambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton. J Biol Chem. 286:14670-14680, 2011
  • Ozono K, Michigami T. Hypophosphatasia now draws more attention of both clinicians and researchers: a commentary on Prevalence of c. 1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasias in Japanese and effects of the mutation on heterozygous carriers. J Hum Genet. 56:174-176, 2011
  • Kawai M, Modder U, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov. 10:141-156, 2011
  • Sugita A, Kawai S, Hayashibara T, Amano A, Ooshima T, Michigami T, Yoshikawa H, Yoneda T. Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis. J Biol Chem. 286:3094-3103, 2011

2010

  • Yamazaki M, Ozono K, Okada T, Tachikawa K, Kondou H, Ohata Y, Michigami T. Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells. J Cell Biochem. 111:1210-1221, 2010
  • Kimata M, Michigami T*, Tachikawa K, Okada T, Koshimizu T, Yamazaki M, Kogo M, Ozono K. Signaling of inorganic extracellular phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the type III Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway. Bone. 47:938-947,2010 (*Corresponding author)
  • Kubota T, Michigami T, Ozono K. Wnt signaling in bone. Clin Pediatr Endocrinol. 19:49-56, 2010
  • Nakamura-Utsunomiya A, Okada S, Hara K, Miyagawa S, Takeda K, Fukuhara R, Nakata Y, Hayashidani M, Tachikawa K, Michigami T, Ozono K, Kobayashi M. Clinical characteristics of perinatal lethal hypophosphatasia: A report of 6 cases. Clin Pediatr Endocrinol. 19:7-13, 2010

2009

  • Ohata Y, Yamamoto T, Mori I, Kikuchi T, Michigami T, Imanishi Y, Satomura K, Ida S, Ozono K. Severe arterial hypertension: a possible complication of McCune-Albright syndrome. Eur J Pediatr. 168:871-876, 2009
  • Matsui Y, Michigami T, Tachikawa K, Yamazaki M, Kawabata H, Nishimura G. Czech dysplasia occurring in a Japanese family. Am J Med Genet(A). 149A:2285-2289, 2009
  • Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab.27:265-271, 2009
  • Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T. Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function. J Cell Biochem. 106:1090-1101, 2009

2008

  • Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T. Causes and differential diagnosis of hypocalcemia-recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan-. Endocr J. 55:787-794, 2008
  • Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K. Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res. 23:1661-1671, 2008
  • Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T. Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients. Proposal of diagnostic criteria using FGF23 measurement. Bone. 42:1235-1239, 2008
  • Suzuki A, Ozono K, Kubota T, Kondou H, Tachikawa K, Michigami T. PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3betain osteoblastic Saos-2 cells. J Cell Biochem. 104:304-317, 2008

2007

  • Kawai M, Mushiake S, Bessho K, Murakami M, Kokubu C, Michigami T, Ozono K. Wnt/Lrp/β-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARγ and C/EBPα. Biochem Biophys Res Commun. 363:276-282, 2007
  • Uchihashi T, Kimata M, Tachikawa K, Koshimizu T, Okada T, Ihara-Watanabe M, Sakai N, Kogo M, Ozono K, Michigami T. Involvement of nuclear factor I transcription/replication factor in the early stage of chondrocytic differentiation. Bone.41:1025-1035, 2007
  • Yamamoto T, Michigami T, Aranami F, Segawa H, Yoh K, Nakajima S, Miyamoto KI, Ozono K. Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene IIc and osteoblastic function. J Bone Miner Metab. 25:407-413, 2007

2006

  • Ozono K, Michigami T, Namba N, Nakajima S, Yamamoto T. Molecular bases of diseases characterized by hypophosphatemia and phosphaturia: New understanding. Clin Pediatr Endocrinol. 15:129-135, 2006
  • Yamazaki M, Suzuki A, Ozono K, Michigami T. G-protein stimulatory alpha subunit is involved in osteogenic activity in osteoblastic cell line SaOS-2 cells. Clin Pediatr Endocrinol. 15:65-72, 2006
  • Miyoshi Y, Santo Y, Tachikawa K, Namba N, Hirai H, Mushiake S, Nakajima S, Michigami T, Ozono K. Lack of puberty despite elevated estradiol in a 46,XY phenotypic female with Frasier symdrome.Endocr J. 53:371-376, 2006
  • Goto T, Matsui Y, Fernandes RJ, Hanson DA, KuboT, Yukata K, Michigami T, Komori T, Fujita T, Yang L, Eyre DR, Yasui N. Sp1 family of transcription factors regulates the human alpha2(XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 21:661-673, 2006

2005

  • Miyauchi Y, Michigami T*, Sakaguchi N, Sekimoto T, Yoneda Y, Pike JW, Yamagata M, Ozono K. Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. J Biol Chem. 280:40901-40908, 2005 (*corresponding author)
  • Yamagata M, Ozono K, Hashimoto Y, Miyauchi Y, Kondou H, Michigami T. Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter.J Am Soc Nephrol. 16:2338-2345, 2005
  • Michigami T, Uchihashi T, Suzuki A, Tachikawa K, Nakajima S, Ozono K. Common mutations F310L and T1559del in tissue-nonspecific alkaline phosophatase gene are related to distinct phenotype in Japanese patients with hypophosphatasia. Eur J Pediatr. 164:277-282, 2005
  • Ozono K, Nakajima S, Michigami T. Vitamin D and reproductive organs. In: Feldman D, Pike JW, Glorieux FH (eds)Vitamin D, 2nd Edition. Elsevier Academic Press, Burlington, 851-861,

2004

  • Ihara-Watanabe M, Uchihashi T, Miyauchi Y, Sakai N, Yamagata M, Ozono K, Michigami T. Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis. J Cell Biochem. 93:418-426, 2004
  • Santo Y, Hirai H, Shima M, Yamagata M, Michigami T, Nakajima S, Ozono K. Examination of megalin in renal tubular epithelium from patients with Dent disease. Pediatr Nephrol.19:612-615, 2004

2003

  • Kondou H, Mushiake S, Etani Y, Miyoshi Y, Michigami T, Ozono K. A blocking peptide for transforming growth factor-b1 activation prevents hepatic fibrosis in vivo.J Hepatol. 39:742-748, 2003
  • Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR, Yoneda T. C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis.Cancer Res.63:5028-5033, 2003

2002

  • Michigami T, Kageyama T, Satomura K, Shima M, Yamaoka K, Nakayama M, Ozono K. Novel mutations in the a3 subunit of vacuolar H+-adenosine triphosphatase in a Japanese patient with infantile malignant osteopetrosis. Bone. 30:436-439, 2002
  • Michigami T, Hiraga T, Williams PJ, Niewolna M, Nishimura R, Mundy GR, Yoneda T. The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast Cancer Res Treat. 75:249-258, 2002

2001

  • Yamamoto T, Miyamoto K, Ozono K, Taketani Y, Katai K, Miyauchi A, Shima M, Yoshikawa H, Yoh K, Takeda E, Okada S. Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia. J Bone Miner Metab .19:287-295, 2001
  • Michigami T, Yamato H, Suzuki H, Nagai-Itagaki Y, Sato K, Ozono K. Conflicting actions of parathyroid hormone-related protein and serum calcium as regulators of 25-hydroxyvitamin D3-1a-hydroxylase expression in a nude rat model of humoral hypercalcemia of malignancy. J Endocrinol. 171:249-251, 2001
  • Yanagihara I, Inui K, Yanagihara K, Boku E, Tanaka J, Ozono K, Okada S, Kurahashi H. FISH analysis of peripheral blood cells in Pearson marrow-pancreas syndrome. J Pediatr . 139:452-455,2001
  • Matsui Y, Kawabata H, Ozono K, Yasui N. Skeletal development of achondroplasia: analysis of genotyped patients. Pediatr Int. 43:361-363, 2001
  • Matsui Y, Nakata K, Araki N, Ozono K, Fujita Y, Tsumaki N, Kawabata H, Yasui N, Sekiguchi K and Yoshikawa H. Alternative splicing of fibronectin transcripts in osteochondrogenic tumors. Anticancer Res. 21:1103-1106, 2001
  • Yamagata M, Kimoto A, Michigami T, Nakayama M, Ozono K. Hydroxylases involved in vitamin D metabolism are differentially expressed in murine embryonic kidney: Application of whole mount in situ hybridization. Endocrinology. 142:3223-3230, 2001
  • Hatakeyama S, Okano T, Maeyama J, Esumi T, Hiyamizu H, Iwabuchi Y, Nakagawa K, Ozono K, Kawase A, Kubodera N. Synthesis and evaluation of A-ring diastereomers of 1alpha,25-dihydroxy-22-oxavitamin D3 (OCT). Bioorg Med Chem. 9:403-415, 2001
  • Matsui Y, Yasui N, Ozono K, Yamagata M, Kawabata H, Yoshikawa H. Loss of the SEDL gene product (Sedlin) causes X-linked spondyloepiphyseal dysplasia tarda: Identification of a molecular defect in a Japanese family. Am J Med Genet. 99:328-330, 2001
  • Nakagawa K, Sowa Y, Kurobe M, Ozono K, Siu-Caldera M, Reddy GS, Uskokovic MR, Okano T. Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D3 analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis. Steroids. 66:327-337, 2001
  • Ishizuka S, Miura D, Ozono K, Saito M, Eguchi H, Chokki M, Norman AW. (23S)- and (23R)-25-dehydro-1a-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1a,25-dihydroxyvitamin D3. Steroids. 66:227-237, 2001
  • Michigami T, Ihara-Watanabe M, Yamazaki M, Ozono K. Receptor activator of NF-kB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly- developed model of human neuroblastoma. Cancer Res. 61:1637-1644, 2001
  • Ishizuka S, Miura D, Ozono K, Chokki M, Mimura H, Norman AW. Antagonistic actions in vivo of (23S)-25-dehydro-1a-hydroxyvitamin D3-26,23-lactone on calcium metabolism induced by 1a,25-dihydroxyvitamin D3. Endocrinology. 142:59-67, 2001
  • Hirai H, Nakajima S, Miyauchi A, Nishimura K, Shimizu N, Shima M, Michigami T, Ozono K, Okada S. A novel activating mutation in calcium-sensing receptor gene (C129S) in a Japanese family with autosomal dominant hypocalcemia. J Hum Genet. 46:41-44, 2001

2000

  • Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha4beta1-integrin enhances production of osteoclast-stimulating activity. Blood. 96:1953-1960, 2000
  • Ishizuka S, Miura D, Eguchi H, Ozono K, Chokki M, Kamimura T, Norman AW. Antagonistic action of novel 1a,25-dihydroxyvitamin D3-26,23-lactone analogs on 25-dihydroxyvitamin D3-24-hydroxylase gene expression induced by 1a,25-dihydroxy vitamin D3 in human promyelocytic leukemia (HL-60) cells. Arch Biochem Biophys. 380:92-102, 2000
  • Kubodera N, Okano T, Nakagawa K, Ozono K, Mikami K. Biological activities of 19-Nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring. Curr Pharm Des. 6:791-801, 2000
  • Nakagawa K, Kurobe M, Ozono K, Konno K, Fujishima T, Takayama H, Okano T. Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D3: transactivation of target genes and modulation of ifferentiation in human promyelocytic leukemia (HL-60) cells. Biochem Pharmacol.59:691-702, 2000
  • Tsugawa N, Nakagawa K, Kurobe M, Ono Y, Kubodera N, Ozono K, Okano T. In vitro biological activities of a series of 2b-substituted analogues of 1a,25-dihydroxyvitamin D3. Biol Pharm Bull. 23:66-71, 2000
  • Mochizuki H, Saito M, Michigami T, Ohashi H, Koda N, Yamaguchi S, Ozono K. Severe hypercalcemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the TNSALP gene. Eur J Pediatr. 159:375-379, 2000
  • Muller HL, Yamazaki M, Michigami T, Kageyama T, Schonau E, Schneider P, Ozono K. Asp361Val mutant of alkaline phosphatase found in patients with dominantly inherited hypophosphatasia inhibits the activity of the wild-type enzyme. J Clin Endocrinol Metab. 85:743-747, 2000
  • Okano T, Nakagawa K, Kubodera N, Isaka A, Osawa A, Terada M, Ozono K, Mikami K. Catalytic asymmetric syntheses and biological activities of a series of singly dehydroxylated19-nor-1a,25-dihydroxyvitamin D3 A-ring analogs in cancer cell differentiation and apoptosis. Chem Biol. 7:173-184, 2000
  • Matsui Y, Yasui N, Kawabata H, Ozono K, Nakata, K, Mizushima T, Tsumaki, N, Kataoka E, Fujita Y, Ochi T. A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia. J Hum Genet.45:105-108, 2000
  • Matsumoto S, Ozono K, Yamamoto T, Yamaoka K, Okamura T, Hara J, Shima M, Okada S. Treatment with recombinant IL-2 for recurrent respiratory infection in a case of cartilage- hair hypoplasia with autoimmune hemolytic anemia. J Bone Miner Metab. 18:36-40, 2000
  • Yanagihara I, Yamagata M, Sakai N, Shukunami C, Kurahashi H, Yamazaki M, Michigami T, Hiraki Y, Ozono K. Genomic organization of the human chondromodulin-1 gene containing a promoter region which confers the expression of reporter gene in chondrogenic ATDC5 cells. J Bone Miner Res. 15:421-429, 2000
  • Nakajima S, Yamagata M, Sakai N, Ozono K. Effect of cyclic adenosine 3', 5'- monophosphate and protein kinase A on ligand-dependent transactivation via the vitamin D receptor. Mol Cell Endocrinol. 159:45-51, 2000

1999

  • Michigami T, Suga A, Yamazaki M, Shimizu C, Cai G, Okada S, Ozono K. Identification of amino acid sequence in the hinge region of human vitamin D receptor which transfers a cytosolic protein to the nucleus. J Biol Chem. 274: 33531-33538, 1999
  • Ozono K, Saito M, Miura D, Michigami T, Nakajima S, Ishizuka S. Analysis of the molecular mechanism for the antagonistic action of a novel 1a,25-dihydroxyvitamin D3 analogue toward vitamin D receptor function. J Biol Chem. 274:32376-32381, 1999
  • Nishimura G, Hong HS, Kawame H, Sato S, Cai G, Ozono K. A mild variant of Desbuquois dysplasia. Eur J Pediatr. 158:479-483, 1999
  • Tsugawa N, Nakagawa K, Kawamoto Y, Tachibana Y, Hayashi T, Ozono K, Okano T. Biological activity profiles of 1alpha,25-dihydroxyvitamin D2, D3, D4, D7, and 24-epi-1alpha,25-dihydroxyvitamin D2. Biol Pharm Bull. 22:371-377, 1999
  • Miura D, Manabe K, Ozono K, Saito M, Gao Q, Norman AW, Ishizuka S. Antagonistic action of novel 1a,25-dihydroxyvitamin D3-26,23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1a,25-dihydroxyvitamin D3. J Biol Chem. 274:16392-16399, 1999
  • Yamagata M, Nakajima S, Tokita A, Sakai N, Yanagihara I, Yabuta K, Ozono K. Analysis of the stable levels of messenger RNA derived from different polymorphic alleles in the vitamin D receptor gene. J Bone Miner Metab. 17:164-170, 1999

1998

  • Okano T, Nakagawa K, Tsugawa N, Ozono K, Kubodera N, Osawa A, Terada M and Mikami K.Singly dehydroxylated A-ring analogues of 19-nor-1a,25-dihydroxyvitamin D3 and19-nor-22-oxa-1a,25-dihydroxyvitamin D3: novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor. Biol Pharm Bull. 21:1300-1305, 1998
  • Etani Y, Mushiake S, Tajiri H, Miki K, Kozaiwa K, Sawada A, Tada K, Ozono K, Okada S. Novel mutation of the down-regulated in adenoma gene in a Japanese case with congenital chloride diarrhea. Hum Mut in Brief Online. 1998
  • Cai G, Michigami T, Yamamoto T, Yasui N, Satomura K, Yamagata M, Shima M, Nakajima S, Mushiake S, Okada S, Ozono K. Analysis of localization of mutated tissue-nonspecific alkaline phosphatase proteins associated with neonatal hypophosphatasia using green fluorescent protein chimeras. J Clin Endocrinol Metab. 83:3936-3942, 1998
  • Yamamoto T, Ozono K, Shima M, Yamaoka K, Okada S. 24R,25-Dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 244:71-76, 1998
  • Ozono K, Yamagata M, Ohyama Y and Nakajima S. Direct repeat 3-type element lacking the ability to bind to the vitamin D receptor enhances the function of a vitamin D-responsive element. J Steroid Biochem Mol Biol. 66:263-269, 1998
  • Nakajima S, Yamagata M, Sakai N, Ozono K. Characterization of the activation function-2 domain of the human 1,25-dihydroxyvitamin D3 receptor. Mol Cell Endocrinol. 139:15-24, 1998
  • Cai G, Nakayama M, Hiraki Y, Ozono K. Mutational analysis of the DTDST gene in a fetus with achondrogenesis type 1B. Am J Med Genet, 78:58-60, 1998
  • Nishimura G, Satoh M, Aihara T, Aida N, Yamamoto T, Ozono K. A distinct subtype of "metatropic dysplasia variant" characterized by advanced carpal skeletal age and subluxation of the appendicular joint. Pediatr Radiol. 28:120-125, 1998
  • Sakai N, Fukushima H, Inui K, Fu L, Nishigaki T, Yanagihara I, Tatsumi N, Ozono K, Okada S. Human galactocerebrosidase gene: promoter analysis of the 5'-flanking region and structural organization.Biochim Biophys Acta. 1395:62-67, 1998

1997

  • Nakajima S, Yanagihara I, Ozono K. A 65 kilodalton nuclear protein binds to the human vitamin D receptor: A bacterial expressed histidine tagged receptor study. Biochem Biophys Res Commun. 232:806-809, 1997
  • Ozono K, Abumi R, Kitabatake K, Akazawa K, Nakayama M. Delayed bone age observed in fetuses with symmetrical intrauterine growth retardation assessed by the ossification of selected bones. Clin Pediatr Endocrinol. 6:1-6, 1997
  • Uchida M, Ozono K, Pike JW. In vitro binding of vitamin D receptor occupied by 24R, 25-dihydroxyvitamin D3 to vitamin D responsive element of human osteocalcin gene. J Steroid Biochem Mol Biol. 60:181-187, 1997
  • Ozono K, Mushiake S, Takeshima T, Nakayama M. Diagnosis of congential cytomegalovirus infection by examination of placenta: Application of polymerase chain reaction and in situ hybridization. Pediatr Pathol Lab Med. 17:249-258, 1997

1996

  • Ozono K, Yamagata M, Michigami T, Nakajima S, Sakai N, Cai G, Satomura K, Yasui N, Okada S, Nakayama M. Identification of novel mutations (Phe310Leu and Gly439Arg) in a neonatal case of hypophosphatasia. J Clin Endocrinol Metab. 81:4458-4461, 1996
  • Yamamoto T, Yamamoka K, Yamamoto K, Ozono K, Michigami T, Matsumoto S, Hiroshima K, Nakahara H, Okada S. The role of insulin like growth factor I for the impaired growth of the patients with hypophosphatemic vitamin D resistant rickets. J Bone Miner Metab. 14:222-228, 1996
  • Akamatsu H, Ichihara-Tanaka K, Ozono K, Kamiike W, Matsuda H, Sekiguchi K. Suppression of transformed phenotype of human fibrosarcoma cells by overexpression of recombinant fibronectin. Cancer Res. 56:4541-4546, 1996
  • Michigami T, Yamato H, Mushiake S, Nakayama M, Yoneda A, Satomura K, Imura K, Ozono K. Hypercalcemia associated with infantile fibrosarcoma producing parathyroid hormone-related protein. J Clin Endocrinol Metab. 81:1090-1095, 1996
  • Sakai N, Inui K, Tatsumi N, Fukushima H, Nishigaki T, Taniike M, Nishimoto J, Tsukamoto H, Yanagihara I, Ozono K, Okada S. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. J Neurochem. 66:1118-1124, 1996
  • Yamamoto T, Ozono K, Kasayama S, Yoh K, Hiroshima K, Takagi M, Matsumoto S, Michigami T, Yamamoto K, Kishimoto T, Okada S. Increased IL-6 production by cells isolated from the fibrous bone dysplasia tissues in patients with McCune-Albright syndrome. J Clin Invest . 98:30-35, 1996
  • Ohyama Y, Ozono K, Uchida M, Yoshimura M, Shinki T, Suda T, Yamamoto O. Function of two vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase gene. J BiolChem. 271:30381-30385, 1996