学術情報集

専門研究の成果はいち早く学会等に発表し、原因解明、創薬、
治療法方の改良、専門家の育成など幅広い分野に貢献しています。

疾患関連分子解析部門

環境関連分子解析部門

研究論文発表

  1. Peripheral neuropathy in the twitcher mouse: accumulation of extracellular matrix in the endoneurium and aberrant expression of ion channels. Kagitani-Shimono K, Mohri I, Yagi T, Taniike M, Suzuki K. Acta Neuropathol. 2008 Jan. Epub ahead of print.
  2. Restless legs syndrome (RLS): An unrecognized cause for bedtime problems and insomnia in children. Mohri I, Kato-Nishimura K, Tachibana N, Ozono K, Taniike M. Sleep Med. 2007 Oct 6; [Epub ahead of print]
  3. Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter. Namba N, Etani Y, Kitaoka T, Nakamoto Y, Nakacho M, Bessho K, Miyoshi Y, Mushiake S, Mohri I, Arai H, Taniike M, Ozono K. Eur J Pediatr. 2007 Sep 25; [Epub ahead of print]
  4. レストレス・レッグズ症候群, 毛利育子、チャイルドヘルス 10(9):13-14. 2007.
  5. 子どもの睡眠時無呼吸症候群、加藤久美、チャイルドヘルス　10(9):12-13. 2007.
  6. 発達障害児における睡眠障害、谷池雅子、チャイルドヘルス　10(9):14-15. 2007.
  7. Body weight reduction by CPAP treatment in a bedridden patient. Kato-Nishimura K, Taniike M, Tachibana N. Sleep Med. 2008 Mar;9(2):207-8.
  8. Neuronal intranuclear hyaline inclusion disease with rapidly progressive neurological symptoms. Mano T, Takizawa S, Mohri I, Okinaga T, Shimono K, Imai K, Taniike M, Ozono K, Fujimura H. J Child Neurol. 2007 Jan;22(1):60-6. .
  9. Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease. Mohri I, Kadoyama K, Kanekiyo T, Sato Y, Kagitani-Shimono K, Saito Y, Suzuki K, Kudo T, Takeda M, Urade Y, Murayama S, Taniike M. J Neuropathol Exp Neurol. 2007 Jun;66(6):469-80.
  10. Early induction of neuronal lipocalin-type prostaglandin D synthase after hypoxic-ischemic injury in developing brains. Taniguchi H, Mhri I, Okabe-Arahori H, Kanekiyo T, Kagitani-Shimono K, Wada K, Urade Y, Nakayama M, Ozono K, Taniike M. Neurosci Lett. 2007 Jun 8;420(1):39-44.
  11. Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. Taniguchi H, Mohri I, Okabe-Arahori H, Aritake K, Wada K, Kanekiyo T, Narumiya S, Nakayama M, Ozono K, Urade Y, Taniike M. J Neurosci. 2007 Apr 18;27(16):4303-12.
  12. Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid. Kanekiyo T, Ban T, Aritake K, Huang ZL, Qu WM, Okazaki I, Mohri I, Murayama S, Ozono K, Taniike M, Goto Y, Urade Y. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6412-7.
  13. The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. Waguri S, Tomiyama Y, Ikeda H, Hida T, Sakai N, Taniike M, Ebisu S, Uchiyama Y. Exp Cell Res. 2006 Dec 10;312(20):4090-107.
  14. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. Mohri I, Taniike M, Taniguchi H, Kanekiyo T, Aritake K, Inui T, Fukumoto N, Eguchi N, Kushi A, Sasai H, Kanaoka Y, Ozono K, Narumiya S, Suzuki K, Urade Y. J Neurosci. 2006 Apr 19;26(16):4383-93.
  15. Six novel mutations detected in the GALC gene in 17 Japanese patients with Krabbe disease, and new genotype-phenotype correlation. Xu C, Sakai N, Taniike M, Inui K, Ozono K. J Hum Genet. 2006;51(6):548-54.
  16. Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides. Mohri I, Taniike M, Okazaki I, Kagitani-Shimono K, Aritake K, Kanekiyo T, Yagi T, Takikita S, Kim HS, Urade Y, Suzuki K. J Neurochem. 2006 May;97(3):641-51.
  17. Pathophysiological role of L-PGDS in neurological disorders. Research Signpost, (ed. by Ragolia, L.) 2008. Taniike M, Mohri I.

動物モデル解析部門

  1. Tanaka K, Shintani N, Hashimoto H , Kawagishi N, Ago Y, Matsuda T , Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A: Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J. Neurosci. 26(19): 5091-5097, 2006
  2. Shintani N, Hashimoto H , Tanaka K, Kawagishi N, Kawaguchi C, Hatanaka M, Ago Y, Matsuda T, Baba A : Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1 -/- ). Ann. N. Y. Acad. Sci. 1070, 545-549, 2006.
  3. Y. Ago, S. Nakamura, M. Uda, Y. Kajii, M. Abe, A. Baba, T. Matsuda : Attenuation by the 5-HT 1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology 51(4), 914-922, 2006.
  4. S. Nakamura, Y. Ago, A. Hayashi, S. Itoh, M. Kakuda , H. Hashimoto , A. Baba, T. Matsuda : Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse, 60(7), 479-484, 2006.
  5. Y. Ago, S. Nakamura, A. Hayashi, S. Itoh, A. Baba, T. Matsuda : Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacol. Biochem. Behav. 85(1), 198-205, 2006.
  6. T. Harasawa, Y. Ago, S. Itoh, A. Baba, T. Matsuda: Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice. Behav. Pharmacol. 17(7), 637-640, 2006.
  7. Morita Y, Yanagida D, Shintani N, Ogita K, Nishiyama N, Tsuchida R, Hashimoto H , Baba A: Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice. Ann. N. Y. Acad. Sci. 1070:450-456, 2006
  8. Hirose M, Hashimoto H , Iga J, Shintani N, Nakanishi M, Arakawa N, Shimada T, Baba A: Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells. Ann. N. Y. Acad. Sci. 1070:342-347, 2006
  9. Hashimoto H , Shintani N, Baba A: New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice. Ann. N. Y. Acad. Sci. 1070:75-89, 2006
  10. Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, Hashimoto H , Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc. Natl. Acad. Sci. USA. 103(19):7488-7493, 2006
  11. Koda K, Ago Y, Kawasaki T, Hashimoto H, Baba A, Matsuda T. Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice. Psychopharmacology (Berl). 2007 Oct 3; [Epub ahead of print]
  12. Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, Baba A, Matsuda T. Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice. Peptides. 2007, 28(9):1674-9.
  13. Ago Y, Nakamura S, Kajita N, Uda M, Hashimoto H, Baba A, Matsuda T. Ritanserin reverses repeated methamphetamine-induced behavioral and neurochemical sensitization in mice. Synapse. 2007, 61(9):757-63.
  14. Kawasaki T, Ishihara K, Ago Y, Baba A, Matsuda T. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J Pharmacol Exp Ther. 2007, 322(1):274-81.
  15. Ago Y, Takahashi K, Nakamura S, Hashimoto H, Baba A, Matsuda T. Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test. J Pharmacol Sci. 2007, 104(2):153-8.
  16. Sato M, Ago Y, Koda K, Nakamura S, Kawasaki T, Baba A, Matsuda T. Role of postsynaptic serotonin1A receptors in risperidone-induced increase in acetylcholine release in rat prefrontal cortex. Eur J Pharmacol. 2007, 559(2-3):155-60.

倫理・情報管理室

西村高宏 . 被験者として小児が参加する臨床研究における倫理的課題 . 『医療・生命と倫理・社会　第 7 号』 2008 年 in press.