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HOME > Research progress / Achievements > Achievements > 2012-2013: Proposed research project 19
Achievements

2012-2013: Proposed research project 19

Molecular mechanism underlying the Hippo pathway-mediated three dimensional construction of the neural tube and blood vessel system
Outline
Research progress
Leader : Yoichi Asaoka

Original Papers

  • Shimomura, T., Miyamura, N., Hata, S., Miura, R., Hirayama, J., Nishina, H. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun. 443: 917-923, 2014.
  • Arima, N., Uchida, Y., Yu, R., Nakayama, K., Nishina, H. Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem. Biophys. Res. Commun. 435: 447-453, 2013.
  • Oudhoff, M.J., Freeman, S.A., Couzens, A.L., Antignano, F., Kuznetsova, E., Min, P.H., Northrop, J.P., Lehnertz, B., Barsyte-Lovejoy, D., Vedadi, M., Arrowsmith, C.H., Nishina, H., Gold, M.R., Rossi, F.M., Gingras, A.C., Zaph, C. Control of the Hippo pathway by Set7-dependent methylation of Yap. Dev. Cell 26: 188-194, 2013.
  • Shoji, Hata., Jun, Hirayama., Hiroaki, Kajiho., Kentaro, Nakagawa., Yutaka, Hata., Toshiaki, Katada., Makoto, Furutani-Seiki. and Hiroshi, Nishina. A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem. 287: 22089-22098, 2012.
  • Yoshimi, Uchida., Tomomi, Osaki., Tokiwa, Yamasaki., Tadanori, Shimomura., Shoji, Hata., Kazumasa, Horikawa., Shigenobu, Shibata., Takeshi, Todo., Jun, Hirayama. and Hiroshi, Nishina. Involvement of the Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in the Regulation of the Mammalian Circadian Clock. J. Biol. Chem. 287: 8318-8326, 2012.
  • Yoshimi, Uchida., Tadanori, Shimomura., Jun, Hirayama. and Hiroshi, Nishina. Light, reactive oxygen species, and magnetic fields activate ERK/MAPK signaling pathway in cultured zebrafish cells. Appl. Magn. Reson. 42: 69-77, 2012.
  • Miki, Nishio., Koichi, Hamada., Kohichi, Kawahara., Masato, Sasaki., Fumihito, Noguchi., Shuhei, Chiba., Kensaku, Mizuno., Satoshi O, Suzuki., Youyi, Dong., Masaaki, Tokuda., Takumi, Morikawa., Hiroki, Hikasa., Jonathan, Eggenschwiler., Norikazu, Yabuta., Hiroshi, Nojima., Kentaro, Nakagawa., Yutaka, Hata,, Hiroshi, Nishina., Koshi, Mimori., Masaki, Mori., Takehiko, Sasaki., Tak W, Mak., Toru, Nakano., Satoshi, Itami., and Akira, Suzuki. Cancer Susceptibility and embryonic lethality in Mob1A/1B double mutant mice. J. Clin. Invest. 3;122(12): 4505-4518, 2012.
  • Tadashi, Yokoi., Yuko, Seko., Tae, Yokoi., Hatsune, Makino., Shin, Hatou., Masakazu, Yamada., Tohru, Kiyono., Akihiro, Umezawa., Hiroshi, Nishina., Noriyuki, Azuma. Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential. PLoS ONE 7(1): e29677, 2012.
  • Ken, Okada., Akihide, Kamiya., Keiichi, Ito., Ayaka, Yanagida., Hidenori, Ito., Hiroki, Kondou., Hiroshi, Nishina. and Hiromitsu, Nakauchi. Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells and Development 21: 1124-1133, 2012.
  • Yuko, Mizunaga., Shuji, Terai., Naoki, Yamamoto., Koichi, Uchida., Takahiro, Yamasaki., Hiroshi, Nishina., Yusuke, Fujita., Koh, Shinoda., Yoshihiki, Hamamoto. and Isao, Sakaida. Granulocyte Colony-Stimulating Factor and Interleukin-1β Are Important Cytokines in Repair of the Cirrhotic Liver After Bone Marrow Cell Infusion: Comparison of Humans and Model Mice. Cell Transplantation 21: 2363-2375, 2012.
  • Takuya, Iwamoto., Shuji, Terai., Yuko, Mizunaga., Naoki, Yamamoto., Kaoru, Omori., Koichi, Uchida., Takahiro, Yamasaki., Yasuhiko, Fujii., Hiroshi, Nishina. and Isao, Sakaida. Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients J. Gastroenterol. 47: 300-312, 2012.
  • Toshiyuki, Oishi., Shuji, Terai., Shinya, Kuwashiro., Koichi, Fujisawa., Toshihiko, Matsumoto., Hiroshi, Nishina. and Isao, Sakaida. Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Biochem. Biophys. Res. Commun. 422: 22-27, 2012.

Review Papers

  • Asaoka, Y., Terai, S., Sakaida, I., Nishina, H. The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis. Model. Mech. 6: 905-914, 2013.
  • Tokiwa, Yamasaki., Hiroshi, Kawasaki. and Hiroshi, Nishina. (2012) [review] Diverse roles of JNK and MKK pathways in the brain. J. Signal Trans. 2012: 459265.
2012-2013: Project 18 Index of Projects 2012-2013: Project 20
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