（全論文リストは左欄の各年代別ページへ）

Tokunaga M, Kokubu C, Maeda Y, Sese J, Horie K, Sugimoto N, Kinoshita T, Yusa K, and Takeda J. Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells. BMC Genomics. 15(1): 1016, 2014
[ Pubmed ]

Igawa K., Kokubu C., Yusa K., Horie K., Yoshimura Y., Yamauchi K., Suemori H., Yokozeki H., Toyoda M., Kiyokawa N., Okita H., Miyagawa Y., Akutsu H., Umezawa A., Katayama I. and Takeda J. Removal of reprogramming transgenes improves tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells. STEM CELLS Translational Medicine. 3(9): 992-1001. 2014
[ Pubmed ]

Kokubu C. and Takeda J. When half is better than the whole: advances in haploid embryonic stem cell technology. Cell Stem Cell. 14(3): 265-7. 2014.
[ Pubmed ]

Yamanishi A., Yusa K., Horie K., Tokunaga M., Kusano K., Kokubu C. and Takeda J., Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase. Genome Research. 23(9):1462-73. 2013
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Horie K., C. Kokubu, J. Yoshida, K. Akagi, A. Isotani, A. Oshitani, K. Yusa, R. Ikeda, Y. Huang, A. Bradley, J. Takeda. A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. Nat. Methods, 8: 1071-1077, 2011.
[ Pubmed ]

Horie K, Kokubu C, Takeda J. Functional genomics in the mouse using the sleeping beauty transposon system. Methods Enzymol. 477:71-89,2010
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Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y. Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. Proc Natl Acad Sci U S A. Feb 23;107(8):3846-51.2010
[ Pubmed ]

Kokubu C, Horie K, Abe K, Ikeda R, Mizuno S, Uno Y, Ogiwara S, Ohtsuka M, Isotani A, Okabe M, Imai K and Takeda J, A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in the mouse genome. Nature Genet. 41: 946-52. 2009
[ Pubmed ]

Yusa K , Rad R, Takeda J, Bradley A, Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat. Methods, 6; 363-369, 2009
[ Pubmed ]

Saito ES, Keng VW, Takeda J, Horie K, Translation from nonautonomous type IAP retrotransposon is a critical determinant of transposition activity: implication for retrotransposon-mediated genome evolution. Genome Res. Jun;18(6):859-68,2008
[ Pubmed ]

Horie K, Saito ES, Keng VW, Ikeda R, Ishihara H and Takeda J;　Retrotransposons Influence the Mouse Transcriptome: Implication for the Divergence of Genetic Traits, Genetics 176: 815-827, 2007
[ Pubmed ]

Ikeda R, Kokubu C, Yusa K, Keng VW, Horie K and Takeda J. Sleeping Beauty transposase has an affinity for heterochromatin conformation, Mol. Cell. Biol., 27; 1665-1676, 2007
[ Pubmed ]

Kitada K, S. Ishishita, K. Tosaka, R. Takahashi, M. Ueda, V.W. Keng, K. Horie, J. Takeda ; Transposon-tagged mutagenesis in the rat. Nat. Methods. 4: 131-133, 2007.
[ Pubmed ]

Hayakawa T., K. Yusa, M. Kouno, J. Takeda, K. Horie ; Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer. Gene. 369: 80-89, 2006.
[ Pubmed ]

Keng V.W., K. Yae, T. Hayakawa, S. Mizuno, Y. Uno, K. Yusa, C. Kokubu, T. Kinoshita, K. Akagi, N.A. Jenkins, N.G. Copeland, K. Horie, J. Takeda ; Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat. Methods. 2: 763-769, 2005.
[ Pubmed ]

Kondoh, G., H. Tojo, Y. Nakatani, N. Komazawa, C. Murata, K. Yamagata, Y. Maeda, T. Kinoshita, M. Okabe, R. Taguchi and J. Takeda. Angiotensin-converting Enzyme is a GPI-anchored Protein Releasing Factor Crucial for Fertilization. Nature Med. 11; 160-166, 2005
[ Pubmed ]

Yusa, K., K. Horie, G. Kondoh, M. Kouno, Y. Maeda, T. Kinoshita, and J. Takeda. Genome-wide phenotype analysis in ES cells by regulated disruption of the Bloom’s syndrome gene. Nature 429, 896-899, 2004
[ Pubmed ]

Yusa, K., J. Takeda, and K. Horie. Enhancement of Sleeping Beauty Transposition by CpG Methylation: Possible Role of Heterochromatin Formation, Mol.Cell.Biol., 24; 4004-4018, 2004
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Takagi, S., H. Tojo, S. Tomita, S. Sano, S. Itami, M. Hara, S. Inoue, K. Horie, G. Kondoh, K. Hosokawa, F.J.Gonzalez , J. Takeda. Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt deficient mice affects skin barrier function. J. Clin. Invest. 112（9）: 1372-1382. 2003
[ Pubmed ]

Horie, K., K.Yusa, K.Yae, J. Odajima, S. E.J.Fischer, V.W. Keng, T.Hayakawa, S. Mizuno, G.Kondoh, T. Ijiri, Y.Matsuda, R.H.A. Plasterk, J. Takeda. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol.Cell.Biol.23(24): 9189-9207, 2003
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Koike, H., K. Horie, H. Fukuyama, G. Kondoh, S. Nagata, and J. Takeda. Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination EMBO Rep.3: 433-437, 2002
[ Pubmed ]

Sano, S., Y. Takahama, T. Sugawara, H. Kosaka, S. Itami, W. van Ewijk, and J. Takeda. Stat3 in thymic epithelial cells is essential for postnatal maintainance of thymic architecture and thymocyte survival. Immunity 15: 261-273, 2001
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Horie, K., A. Kuroiwa, M. Ikawa, M. Okabe, G. Kondoh, Y. Matsuda and J. Takeda. Efficient chromosomal transposition of a Tc1/mariner-like transposon Sleeping Beauty in mice. Proc. Natl. Acad. Sci. USA 98: 9191-9196, 2001
[ Pubmed ]

Sano, S., S. Itami, K. Takeda, M. Tarutani, Y. Yamaguchi, H. Miura, K. Yoshikawa, S. Akira, and J. Takeda. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18:4657-4668, 1999.
[ Pubmed ]

Tarutani, M., S. Itami, M. Okabe, M. Ikawa, T. Tezuka, K. Yoshikawa, T. Kinoshita, and J. Takeda. Tissue specific knock-out of the mouse Pig-a gene reveals important roles for GPI anchored proteins in skin development. Proc. Natl. Acad. Sci. USA, 94 : 7400-7405, 1997.
[ Pubmed ]

Takeda, J., T. Miyata, K. Kawagoe, Y. Iida, Y. Endo, T. Fujita, M.Takahashi, T. Kitani, and T. Kinoshita. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell, 73:703-711, 1993.
[ Pubmed ]

Miyata, T., J. Takeda, Y. Iida, N. Yamada, N. Inoue, M. Takahashi, K. Maeda, T. Kitani, and T. Kinoshita. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science, 259:1318-1320, 1993.
[ Pubmed ]