*Miyake K, Costa Cruz PH, Nagatomo I, Kato Y, Motooka D, Satoh S, Adachi Y, Takeda Y, *Kawahara Y, *Kumanogoh A.
A cancer-associated METTL14 mutation induces aberrant m6A modification affecting tumor growth.
Cell Reports, 42(7), 112688, 2023. (*Co-corresponding authors) 研究内容紹介
#Xing Y, #,*Nakahama T, Wu Y, Inoue M, Kim JI, Todo H, Shibuya T, Kato Y, *Kawahara Y.
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
Journal of Biological Chemistry, 299(7), 104840, 2023. (#Co-first authors, *Co-corresponding authors)
Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O.
The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.
Nature Communications, 13, 6435, 2022.
Sugihara R, *Kato Y, Mori T, Kawahara Y.
Alignment of single-cell trajectory trees with CAPITAL.
Nature Communications, 13, 5972, 2022. 研究内容紹介
#Inoue M, #Nakahama T, Yamasaki R, Shibuya T, Kim JI, Todo H, Xing Y, Kato Y, Morii E, *Kawahara Y.
An Aicardi-Goutières syndrome–causative point mutation in Adar1 gene invokes multiorgan inflammation and late-onset encephalopathy in mice.
The Journal of Immunology, 207(12): 3016-3027, 2021. (#Co-first authors)
Nakahama T, Kato Y, Shibuya T, Inoue M, Kim JI, Vongpipatana T, Todo H, Xing Y, and *Kawahara Y.
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières syndrome–like encephalopathy.
Immunity, 54: 1976-1988, 2021. Preview研究内容紹介
Uyeda A, Quan L, Kato Y, Muramatsu N, Tanabe S, Sakai K, Ichinohe N, Kawahara Y, Suzuki, T, *Muramatsu R.
Dimethylarginine dimethylaminophdrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination.
Glia, 69(11): 2591-2604, 2021.
#Kim JI, #Nakahama T, Yamasaki R, Costa Cruz PH, Vongpipatana T, Inoue M, Kanou N, Xing Y, Todo H, Shibuya T, Kato Y, *Kawahara Y.
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
PLOS Genetics, 17(5): e1009516, 2021. (#Co-first authors)
Ito M, Muramatsu R, Kato Y, Sharma B, Uyeda A, Tanabe S, Fujimura H, Kidoya H, Takakura N, Kawahara Y, Takao M, Mochizuki H, Fukamizu A, Yamashita T.
Age-dependent decline in remyelination capacity is mediated by apelin–APJ signaling.
Nature Aging, 1: 284-294, 2021.
#Vongpipatana T, #,*Nakahama T, Shibuya T, Kato Y, *Kawahara Y.
ADAR1 regulates early T cell development via MDA5-dependent and -independent pathways.
The Journal of Immunology, 204(8): 2156-2168, 2020. (#Co-first authors)
Shimmura K, *Kato Y, Kawahara Y.
Bivartect: accurate and memory-saving breakpoint detection by direct read comparison.
Bioinformatics, 36(9): 2725-2730, 2020.
Costa Cruz PH, Kato Y, Nakahama T, Shibuya T, *Kawahara Y.
A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.
RNA, 26(4): 454-469, 2020.
*Nakahama T, Kato Y, Kim JI, Vongpipatana T, Suzuki Y, Walkley CR, *Kawahara Y.
ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity.
EMBO Reports, 19, e46303, 2018.
News & Views
Oshima T, Ishiguro K, Suzuki T, *Kawahara Y.
Quantification of methylation efficiency at a specific N6-methyladenosine position in rRNA by using BNA probes.
Chemical Communications, 54(69); 9627-9630, 2018.
Nakasone A, Muramatsu R, Kato Y, Kawahara Y, Yamashita T.
Myotube-derived factor promotes oligodendrocyte precursor cell proliferation.
Biochemical and Biophysical Research Communications, 500(3); 609-613, 2018.
Gallego A, Hartasánchez DA, Brasó-Vives M, Garcia-Ramallo E, Lopez-Valenzuela M, Baena N, Guitart M, Fernández-Bellon H, Kondova I, Bontrop R, Kawahara Y, Espinosa-Parrilla Y.
RNA editing independently occurs at three mir-376a-1 sites and may compromise the stability of the microRNA hairpin.
Gene, 628; 109-116, 2017.
Uemura Y, Oshima T, Yamamoto M, Reyes CJ, Costa Cruz PH, Shibuya T, *Kawahara Y.
Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing. Genes to Cells, 22(9); 785-798, 2017.
Kanemitsu Y, Fujitani M, Fujita Y, Zhang S, Su YQ, Kawahara Y, Yamashita T. The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Scientific Reports, 7(1); 1155, 2017.
Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, *Kawahara Y. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Reports, 17; 2004-2014, 2016.
F1000Prime研究内容紹介
Li Q, Yokoshi M, Okada H, *Kawahara Y. The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity. Nature Communications, 6; 6183, 2015. 研究内容紹介
Li Q, Uemura Y, *Kawahara Y. Cross-Linking and Immunopresipitation of Nuclear RNA-Binding Proteins. Methods in Molecular Biology,1262; 247-263, 2015.
#Yokoshi M, #Li Q, #Yamamoto M, Okada H, Suzuki Y,*Kawahara Y. Direct binding of Ataxin-2 to distinct elements in 3’UTRs promotes mRNA stability and protein expression. Molecular Cell, 55(2); 186-198, 2014. (#Co-first authors) 研究内容紹介
Nakahama T, Hanieh H, Nguyen NT, Chinen I, Ripley B, Millrine D, Lee S, Nyati KK, Dubey PK, Chowdhury K, Kawahara Y, Kishimoto T. Aryl hydrocarbon receptor-mediated induction of the miR-132/212 cluster promotes TH17 cell differentiation. Proceedings of the National Academy of Sciences U. S. A., 110(29); 11964-11969, 2013.
Matsumoto S, Sakata Y, Nakatani D, Suna S, Usami M, Hara M, Kitamura T, Hamasaki T, Nanto S, *Kawahara Y, *Komuro I. Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circulation Research, 113(3); 322-326, 2013. (*Co-corresponding authors)
Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I. A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction. Biochemical and Biophysical Research Communications, 2012 427(2); 280-284, 2012.
Kin K, Miyagawa S, Fukushima S, Shirakawa Y, Torikai K, Shimamura K, Kawahara Y, Daimon T, Kuratani T, Sawa Y. Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm. Journal of the American Heart Association, 1; e000745, 2012.
*Kawahara Y. Quantification of adenosine-to-inosine editing of microRNAs using a conventional method. Nature Protocols, 7(7); 1426-1437, 2012.
*Kawahara Y and Mieda-Sato I. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proceedings of the National Academy of Sciences U. S. A., 109 (9); 3347-3352, 2012. (*Corresponding author)
Review Articles & Books
Nakahama T, *Kawahara Y.
The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways.
International Immunology, 35(3): 123-133, 2023.
Nakahama T, *Kawahara Y.
Deciphering the Biological Significance of ADAR1–Z-RNA Interactions.
International Journal of Molecular Sciences, 22(21): 11435, 2021.
Costa Cruz PH, *Kawahara Y.
RNA editing in neurological and neurodegenerative disorders.
Methods in Molecular Biology, 2181: 309-330, 2020.
Nakahama T, *Kawahara Y.
Adenosine-to-inosine RNA editing in the immune system: friend or foe?
Cellular and Molecular Life Sciences, 77(15): 2931-2948, 2020
*Kawahara Y, Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes.
Congenital Anomalies, 54(1); 12-21, 2014.
Valente L, Kawahara Y, Zinshteyn B, Iizasa H and Nishikura K. Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing. Post-transcriptional gene regulation: RNA processing in eukaryotes. (Ed. Jane Wu) Wiley-VCH book, 41-82, 2013.