The single-arm multicenter study using heating devices for Raynaud's phenomenon caused by systemic sclerosis: HOCA study
As shown in the figures above, continuous heating near the elbow alleviated Raynaud's phenomenon. To verify these preliminary results, a multicenter study was conducted at several facilities across Japan.
Participating hospotals |
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Sapporo Medical University Hospital |
Saitama Medical University Hospital |
JCHO, Chukyo Hospital |
Osaka University Hospital |
Hyogo Medical University Hospital |
Oita Red Cross Hospital |

We proceeded to a second study that included several facilities across Japan. The findings confirmed our preliminary observation that heating the elbow area alleviated the symptoms of Raynaud syndrome in patients with systemic sclerosis. More details about this study can be found at the following webpage: https://academic.oup.com/mr/article/33/5/968/6705070