Tubulology (Regulation of Polarity Signaling during Morphogenesis, Remodeling, and Breakdown of Epithelial Tubule Structure)

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2012-2013: Proposed research project 21

Tubulogenesis in the embryonic kidney by cytoskeletal regulation

Leader :

Ryuichi Nishinakamura

Taguchi, A., Kaku, Y., Ohmori, T., Sharmin, S., Ogawa, M., Sasaki, H., and Nishinakamura, R. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14(1): 53-67, 2014.
Kaku, Y., Ohmori, T., Kudo, K., Fujimura, S., Suzuki, S., Evans, S.M., Kawakami, K., and Nishinakamura, R. Islet1 deletion causes mouse kidney agenesis and hydroureter resembling CAKUT. J. Am. Soc. Nephrol. 24: 1242-1249, 2013.
Sakaguchi, M., Sharmin, S., Taguchi, A., Ohmori, T., Fujimura, S., Abe, T., Kiyonari, H., Komatsu, Y., Mishina, Y., Asashima, M., Araki, E., Nishinakamura, R. The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth. Nat. Commun. 4: 1398, 2013.
Terabayashi, T., Sakaguchi, M., Shinmyozu, K., Ohshima, T., Johjima, A., Ogura, T., Miki, H., Nishinakamura, R. Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development. PLoS One 7(6): e39714, 2012.