上皮管腔組織形成【文部科学省科学研究費補助金新学術領域研究】

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平成26～27年度：公募研究13

肝臓上皮組織の再生・維持機構の生体内多次元イメージング解析

研究代表者：

伊藤暢

Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S. O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-Ya, K., Mimori, K., Suzuki, A. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc. Natl. Acad. Sci. USA 113: E71-E80, 2016.
Kaneko, K., Kamimoto, K., Miyajima, A., Itoh, T. Adaptive remodeling of the biliary architecture underlies liver homeostasis. Hepatology 61: 2056-2066, 2015.
Taguchi, K., Hirano, I., Itoh, T., Tanaka, M., Miyajima, A., Suzuki, A., Motohashi, H., Yamamoto, M. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers. Mol. Cell. Biol. 34: 900-913, 2014.
Takase, H. M., Itoh, T., Ino, S., Wang, T., Koji, T., Akira, S., Takikawa, Y., Miyajima, A. FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration. Genes Dev. 27: 169-181, 2013.

Itoh, T., Kok, C. Y., Takase, H., Miyajima, A. Liver stem cells (Chapter 8). Regenerative Medicine: From Protocol to Patient, 3rd edition, edited by Steinhoff, G., Springer, (in press).
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Kok, C. Y., Miyajima, A., Itoh, T. Adaptive remodelling of the biliary tree: the essence of liver progenitor cell expansion. J. Hepatobiliary Pancreat. Sci. 22: 546-550, 2015.
Miyajima, A., Tanaka, M., Itoh, T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell 14: 561-574, 2014.
Itoh, T., Miyajima, A. Liver regeneration by stem/progenitor cells. Hepatology 59: 1617-1626, 2014.
Itoh, T., Takase, H., Tanaka, M., Miyajima, A. Liver stem cells (Chapter 13). Regenerative Medicine: From Protocol to Patient, 2nd edition, edited by Steinhoff, G., Springer. 337-363, 2013.