認知行動生理研究室

スタッフ

岩瀬 真生（講師）、石井 良平（医学部講師）、畑　真弘（大学院4年）

研究の内容

当研究室では、近赤外分光法(NIRS)、経頭蓋直流電気刺激(tDCS)、プレパルスインヒビション（PPI）、脳波(EEG)、脳磁図(MEG)等の神経生理学的手法と、認知行動科学的手法を用い、統合失調症、認知症、うつ病、てんかん等の精神神経疾患における認知や情動へのアプローチを進め、これらの疾患の病態生理解明と治療法開発の解明を主な研究テーマとしています。

以下に最近の研究結果の一部を紹介します。

1．近赤外分光法（NIRS）

統合失調症・うつ病・認知症の認知課題施行時のNIRSを用いた脳血流の変化について研究しています。現在統合失調症に関しては、遺伝子、脳機能・形態画像・認知機能・社会機能を統合したプロジェクトを国立精神・神経センター、本学放射線科、教室内の他の研究室と合同で進めています。統合失調症の遺伝子解析に関する研究は本学倫理委員会の承認を得ており、関連病院の皆様方にもご協力頂いています。

また、符号課題を施行中にNIRSを用いて、前頭葉の活動を調べました。7割以上の測定部位で酸素化ヘモグロビンの有意な増加が左側優位に見られました(図1)。

2．経頭蓋直流電気刺激(tDCS)

tDCSを用いた難治性うつ病、統合失調症患者の治療と、tDCSの作用機序の解明をめざす基礎的研究を行っています。

3．プレパルスインヒビション（PPI）

統合失調症患者のプレパルスインヒビション(PPI)を測定し、その病態解明を行っています。

4. 脳波（EEG）

てんかん患者の精神症状やうつ症状に関連した脳波異常の解析を行っています。

5．脳磁図(MEG)

アルツハイマー病（AD）や軽度認知障害（MCI）のMEG活動を解析し、健常高齢者（NC）との脳活動の差を描出しました(図2)。統合失調症の幻聴出現時の側頭葉周辺での神経活動をMEGで捉えました。幻聴を持つてんかん患者の脳内活動部位を推定し、統合失調症との病態の差異を検討しました。

6．統合失調症、自閉症・アスペルガー症候群の認知障害

簡易なパソコンを使用した認知課題を用いて、統合失調症と自閉症患者の情報処理の特徴を調べ、認知障害と臨床的特徴との関連について報告しました。

7. てんかん患者の心理的評価

当院泌尿器科と共同で、腎移植患者の心理的評価を行っています。

8．共同研究

金沢大学、関西医科大学、国立精神・神経センター、兵庫県立大学大学院応用情報科学研究科、スペイン・マドリッド工科大などの学外のほか、学内の産業科学研究所、医学部脳神経外科、放射線科、麻酔科などと活発に進んでいます。

代表的な図表

図1

Fig1
この図は安静時脳波の独立成分分析からデフォルトモードネットワークを調べたものです。独立成分４で後頭部にアルファ波が分布している様子が見られました。（Aoki et al, 2015)

図2

Fig.2
この図は、MEGによって計測されたアルツハイマー病患者（AD）と健常高齢者（NC）の安静閉眼時のアルファ波活動の差を見たものです。本来後頭葉に出現するアルファ波が前頭葉にシフトしている様子が観察できました。(Kurimoto et al, 2008)

代表的な業績

    1. Dissociative experiences in epilepsy: Effects of epilepsy-related factors on pathological dissociation,Epilepsy and Behavior, vol. 44, pp. 185-191, 2015.
    2. Detection of EEG-resting state independent networks by eLORETA-ICA method,-Frontiers in Human Neuroscience, vol. 9, no. FEB, 2015.
    3. Emotion regulation of neuroticism: Emotional information processing related to psychosomatic state evaluated by electroencephalography and exact low-resolution brain electromagnetic tomography,Neuropsychobiology, vol. 71, no. 1, pp. 34-41, 2015.
    4. Association of cerebrospinal fluid tap-related oscillatory activity and shunt outcome in idiopathic normal-pressure hydrocephalus,-Psychogeriatrics, vol. 15, no. 3, pp. 191-197, 2015.
    5. Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus,Scientific Reports, vol. 5, 2015.
    6. Yokukansan and its ingredients as possible treatment options for schizophrenia,-Neuropsychiatric Disease and Treatment, vol. 10, pp. 1629-1634, 2014.
    7. Frontal midline theta rhythm and gamma power changes during focused attention on mental calculation: An MEG beamformer analysis,-Frontiers in Human Neuroscience, vol. 8, no. JUNE, 2014.
    8. Global complexity and cognitive reserve in MCI,-Clinical Neurophysiology, vol. 125, no. 4, pp. 653-654, 2014.
    9. EEG biomarkers of NeuroAIDS,-Clinical Neurophysiology, vol. 125, no. 6, pp. 1075-1076, 2014.
    10. EEG connectome: A new candidate for endophenotypes,-Clinical Neurophysiology, vol. 124, no. 12, pp. 2289-2290, 2013.
    11. A novel heart failure mice model of hypertensive heart disease by angiotensin II infusion, nephrectomy, and salt loading,-American Journal of Physiology - Heart and Circulatory Physiology, vol. 305, no. 11, pp. H1658-H1667, 2013.
    12. EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients,-NeuroImage: Clinical, vol. 3, pp. 522-530, 2013.
    13. Non-parametric permutation thresholding for adaptive nonlinear beamformer analysis on MEG revealed oscillatory neuronal dynamics in human brain,-Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 4807-4810, 2013.
    14. Normalized power variance change between pre-ictal and ictal phase of an epilepsy patient using NAT analysis: A case study,-Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 437-440, 2013.
    15. Frequency diversity of posterior oscillatory activity in human revealed by spatial filtered MEG,-Journal of Integrative Neuroscience, vol. 12, no. 3, pp. 343-353, 2013.
    16. Interleukin-16 Promotes Cardiac Fibrosis and Myocardial Stiffening in Heart Failure with Preserved Ejection Fraction,-PLoS ONE, vol. 8, no. 7, 2013.
    17. Non-parametric permutation thresholding for adaptive nonlinear beamformer analysis on MEG revealed oscillatory neuronal dynamics in human brain,-Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2013, pp. 4807-4810, 2013.
    18. Normalized power variance change between pre-ictal and ictal phase of an epilepsy patient using NAT analysis: a case study,-Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2013, pp. 437-440, 2013.
    19. New possibility of traditional Chinese and Japanese medicine as treatment for behavioral and psychiatric symptoms in dementia,-Clinical Interventions in Aging, vol. 7, pp. 393-396, 2012.
    20. [Repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats].,-Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, vol. 114, no. 9, pp. 1018-1022, 2012.
    21. [Endophenotypes in schizophrenia: a review of electrophysiological studies].,-Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, vol. 114, no. 6, pp. 629-646, 2012.
    22. Publication criteria for evoked magnetic fields of the human brain: A proposal,-Clinical Neurophysiology, vol. 123, no. 11, pp. 2116-2121, 2012.
    23. Heartbeat evoked potentials: A new possible clinical biomarker for depression based on the somatic marker hypothesis,-Clinical Neurophysiology, vol. 123, no. 10, pp. 1899-1900, 2012.
    24. Resting-State Network Disruption and APOE Genotype in Alzheimer's Disease: A lagged Functional Connectivity Study,-PLoS ONE, vol. 7, no. 9, 2012.
    25. Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment,-NeuroImage, vol. 59, no. 4, pp. 4132-4140, 2012.
    26. Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects,Neuroscience Research, vol. 72, no. 2, pp. 187-193, 2012.
    27. Balloon type elasticity sensing for left ventricle of small laboratory animal,-Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 904-907, 2011.
    28. Prepulse inhibition of startle response: Recent advances in human studies of psychiatric disease,-Clinical Psychopharmacology and Neuroscience, vol. 9, no. 3, pp. 102-110, 2011.
    29. Measurement of personality stability in infants and young adults under emotional stimuli using a brain functional reaction method,-International Journal of Intelligent Computing in Medical Sciences and Image Processing, vol. 4, no. 1, pp. 39-64, 2011.
    30. EEG activities evoked by Trauma stimuli related to earthquakes and personality features associated with Trauma,-International Journal of Intelligent Computing in Medical Sciences and Image Processing, vol. 4, no. 1, pp. 13-24, 2011.
    31. Balloon type elasticity sensing for left ventricle of small laboratory animal.,-Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, vol. 2011, pp. 904-907, 2011.
    32. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy,-PLoS ONE, vol. 6, no. 11, 2011.
    33. Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia: A magnetoencephalography-beamformer study,-Neuroscience Research, vol. 71, no. 3, pp. 235-243, 2011.
    34. Schizophrenia-like psychosis associated with right-parietal meningioma,-Journal of Neuropsychiatry and Clinical Neurosciences, vol. 23, no. 3, pp. E36, 2011.
    35. Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy: Evidence from magnetoencephalography,-Psychiatry and Clinical Neurosciences, vol. 65, no. 2, pp. 183-190, 2011.
    36. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons,-Journal of Molecular Neuroscience, vol. 43, no. 3, pp. 326-332, 2011.
    37. Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats,Psychiatry and Clinical Neurosciences, vol. 65, no. 1, pp. 77-81, 2011.
    38. Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance,Behavioural Brain Research, vol. 215, no. 1, pp. 21-27, 2010.
    39. Association study of KIBRA gene with memory performance in a Japanese population,-World Journal of Biological Psychiatry, vol. 11, no. 7, pp. 852-857, 2010.
    40. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects,-Psychophysiology, vol. 47, no. 5, pp. 831-837, 2010.
    41. Frontal shift of posterior alpha activity is correlated with cognitive impairment in early Alzheimer's disease: A magnetoencephalography-beamformer study,-Psychogeriatrics, vol. 10, no. 3, pp. 138-143, 2010.
    42. Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder: An MEG study,-Neuroscience Letters, vol. 478, no. 3, pp. 141-145, 2010.
    43. Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: A near-infrared spectroscopy,-Schizophrenia Research, vol. 117, no. 1, pp. 52-60, 2010.
    44. The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis,-Schizophrenia Research, vol. 116, no. 2-3, pp. 126-132, 2010.
    45. Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography,-Epilepsy and Behavior, vol. 17, no. 1, pp. 109-119, 2010.
    46. Neuroimaging studies in patients with Charles Bonnet Syndrome,-Psychogeriatrics, vol. 9, no. 2, pp. 77-84, 2009.
    47. TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function,-Genes, Brain and Behavior, vol. 8, no. 4, pp. 473-480, 2009.
    48. Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study,Schizophrenia Research, vol. 109, no. 1-3, pp. 80-85, 2009.
    49. Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography,-Clinical Neurophysiology, vol. 120, no. 3, pp. 497-504, 2009.
    50. Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: A two-channel near-infrared spectroscopy study,-Schizophrenia Research, vol. 108, no. 1-3, pp. 93-103, 2009.
    51. Factors associated with impaired quality of life in younger and older adults with epilepsy,-Epilepsy Research, vol. 83, no. 1, pp. 58-65, 2009.
    52. Anterior brain activities related to emotional stress,-2008 World Automation Congress, WAC 2008, 2008.
    53. Severity of depressive symptoms as predictor of impairment of quality of life in chronic migraine: Comparison with episodic migraine,-Psychiatry and Clinical Neurosciences, vol. 62, no. 6, pp. 738-740, 2008.
    54. EEG changes affected trauma related to earthquakes,-2008 World Automation Congress, WAC 2008, 2008.
    55. Tuberous sclerosis: Localizing the epileptogenic tuber with synthetic aperture magnetometry with excess kurtosis analysis,-Journal of Clinical Neuroscience, vol. 15, no. 11, pp. 1296-1298, 2008.
    56. Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia,-Neuroscience Research, vol. 62, no. 3, pp. 187-194, 2008.
    57. Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: An MEG study combining beamformer and group comparison,-Neuroscience Letters, vol. 443, no. 2, pp. 86-89, 2008.
    58. Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia,-Epilepsy Research, vol. 81, no. 2-3, pp. 228-232, 2008.
    59. Cephalic auras of supplementary motor area origin: An ictal MEG and SAM(g2) study,-Epilepsy and Behavior, vol. 13, no. 3, pp. 570-574, 2008.
    60. Frontal activity during the digit symbol substitution test determined by multichannel near-infrared spectroscopy,-Neuropsychobiology, vol. 57, no. 4, pp. 151-158, 2008.
    61. Efficacy of risperidone in the treatment of delirium in elderly patients,-Psychogeriatrics, vol. 8, no. 2, pp. 62-65, 2008.
    62. Slow repetitive transcranial magnetic stimulation changes oscillatory magnetoencephalographic activity in two patients with thalamic pain,-International Congress Series, vol. 1300, pp. 295-298, 2007.
    63. MEG-SAM kurtosis analysis in the localization of the epileptogenic tuber in tuberous sclerosis: A case report,-International Congress Series, vol. 1300, pp. 653-656, 2007.
    64. MEG neuroimaging of delusions in episodic interictal psychosis of epilepsy,-International Congress Series, vol. 1300, pp. 649-652, 2007.
    65. Rhythmic brain activities related to singing in humans,-NeuroImage, vol. 34, no. 1, pp. 426-434, 2007.
    66. Right parietal activation during delusional state in episodic interictal psychosis of epilepsy: A report of two cases,-Epilepsy and Behavior, vol. 9, no. 2, pp. 367-372, 2006.
    67. Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese 'shiritori' word generation task,-Neuropsychobiology, vol. 53, no. 4, pp. 215-222, 2006.
    68. Discrepancy of performance among working memory-related tasks in autism spectrum disorders was caused by task characteristics, apart from working memory, which could interfere with task execution,Psychiatry and Clinical Neurosciences, vol. 60, no. 3, pp. 312-318, 2006.
    69. Wavelet-crosscorrelation analysis: Non-stationary analysis of neurophysiological signals,-Brain Topography, vol. 17, no. 4, pp. 237-252, 2005.
    70. Information processing flow and neural activations in the dorsolateral prefrontal cortex in the stroop task in schizophrenic patients: A spatially filtered MEG analysis with high temporal and spatial resolution,-Neuropsychobiology, vol. 51, no. 4, pp. 191-203, 2005.
    71. Cortical processing of esophageal sensation is related to the representation of swallowing,-NeuroReport, vol. 16, no. 5, pp. 439-443, 2005.
    72. Auditory detection of motion velocity in humans: A magnetoencephalographic study,-Brain Topography, vol. 17, no. 3, pp. 139-149, 2005.
    73. Wavelet-crosscorrelation analysis of electrocorticography recordings from epilepsy,-International Congress Series, vol. 1278, pp. 411-414, 2005.
    74. Effective extraction of high-frequency oscillations by blind source separation,-International Congress Series, vol. 1278, pp. 243-246, 2005.
    75. Effect of bilingualism on cognitive control in the Simon task: Evidence from MEG,-NeuroImage, vol. 24, no. 1, pp. 40-49, 2005.
    76. MEG analysis of 'theory of mind' in emotional vignettes comprehension,-Neurology and Clinical Neurophysiology, vol. 2004, 2004.
    77. SAM(g2) analysis for detecting spike localization: A comparison with clinical symptoms and ECD analysis in an epileptic patient,-Neurology and Clinical Neurophysiology, vol. 2004, 2004.
    78. Dynamic neuromagnetic responses to auditory motion: A novel index for evaluation of attention,Neurology and Clinical Neurophysiology, vol. 2004, 2004.
    79. An integrative MEG-fMRI study of the primary somatosensory cortex using cross-modal correspondence analysis,-NeuroImage, vol. 22, no. 1, pp. 120-133, 2004.
    80. Slow repetitive transcranial magnetic stimulation increases somatosensory high-frequency oscillations in humans,-Neuroscience Letters, vol. 358, no. 3, pp. 193-196, 2004.
    81. The generator of MEG sleep spindle.,-Brain and cognition, vol. 54, no. 2, pp. 157-159, 2004.
    82. Localization of transient and steady-state auditory evoked responses using synthetic aperture magnetometry.,-Brain and cognition, vol. 54, no. 2, pp. 149-151, 2004.
    83. Dynamic neuromagnetic responses to auditory motion: a novel index for evaluation of attention.,Neurology & clinical neurophysiology : NCN, vol. 2004, pp. 106, 2004.
    84. MEG analysis of "theory of mind" in emotional vignettes comprehension.,-Neurology & clinical neurophysiology : NCN, vol. 2004, pp. 28, 2004.
    85. SAM(g2) analysis for detecting spike localization: a comparison with clinical symptoms and ECD analysis in an epileptic patient.,-Neurology & clinical neurophysiology : NCN, vol. 2004, pp. 57, 2004.
    86. Wavelet Analysis for Neonatal Electroencephalographic Seizures,-Pediatric Neurology, vol. 29, no. 4, pp. 326-333, 2003.
    87. Determination of activation areas in the human auditory cortex by means of synthetic aperture magnetometry,-NeuroImage, vol. 20, no. 2, pp. 995-1005, 2003.
    88. Magnetoencephalographic study of the cortical activity elicited by human voice,-Neuroscience Letters, vol. 348, no. 1, pp. 13-16, 2003.
    89. Neuroimaging evidence for cortical involvement in the preparation and in the act of swallowing,NeuroImage, vol. 20, no. 1, pp. 135-144, 2003.
    90. Current source density distribution of sleep spindles in humans as found by synthetic aperture magnetometry,-Neuroscience Letters, vol. 340, no. 1, pp. 25-28, 2003.
    91. Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored elementary visual auras: A 5-year longitudinal MEG ECD study,-NeuroReport, vol. 14, no. 4, pp. 637-640, 2003.
    92. Erratum: MEG study of long-term cortical reorganization of sensorimotor areas with respect to using chopsticks (Neuroreport (2002) 13 (2155-2159)),-NeuroReport, vol. 14, no. 4, pp. 657, 2003.
    93. Neuromagnetic gamma-band activity in the primary and secondary somatosensory areas,-NeuroReport, vol. 14, no. 2, pp. 273-277, 2003.
    94. Parallel distributed processing neuroimaging in the Stroop task using spatially filtered magnetoencephalography analysis,-Neuroscience Letters, vol. 334, no. 1, pp. 9-12, 2002.
    95. MEG study of long-term cortical reorganization of sensorimotor areas with respect to using chopsticks,NeuroReport, vol. 13, no. 16, pp. 2155-2159, 2002.
    96. Frequency-dependent spatial distribution of human somatosensory evoked neuromagnetic fields,Neuroscience Letters, vol. 318, no. 2, pp. 73-76, 2002.
    97. Neuromagnetic spectral distribution of implicit processing of words,-NeuroReport, vol. 12, no. 18, pp. 3923-3927, 2001.
    98. Transient global amnesia (TGA) in an MEG study,-Brain Topography, vol. 13, no. 4, pp. 269-274, 2001.
    99. Theta rhythm increases in left superior temporal cortex during auditory hallucinations in schizophrenia: A case report,-NeuroReport, vol. 11, no. 14, pp. 3283-3287, 2000.
    100. Medial prefrontal cortex generates frontal midline theta rhythm,-NeuroReport, vol. 10, no. 4, pp. 675-679, 1999.

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