RESULTS

MicroRNA profiles involved in trifluridine resistance (Oncotarget, 2017)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Tsunekuni et al. demonstrated the microRNA profiles involved in trifluridine (FTD) resistance.  FTD is a key component of the novel oral antitumor drug trifluridine/tipiracil, which was approved for the treatment of patients with metastatic colorectal cancer refractory to standard chemotherapies. A comprehensive analysis of microRNA profiles was performed in colorectal cell lines resistant to FTD, in order to explore the underlying mechanisms of resistance to the drug. The data indicate the significance of microRNA network and the candidacy of microRNAs as a potential predictive clinical marker of FTD treatment.