RESULTS

Tumour-suppressive function of SIRT4 in human colorectal cancer  (Br. J. Cancer, 2015)

SIRT4, which is localized in the mitochondria, is one of the least characterized members of the sirtuin family of nicotinamide adenine dinucleotide?dependent enzymes that play key roles in multiple cellular processes such as metabolism, stress response and longevity. In collaboration with  the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki) , Miyo et al. studied the significance of SIRT4 in human colorectal cancer. SIRT4 expression decreased with the progression of invasion and metastasis, and a low expression level of SIRT4 was correlated with a worse prognosis. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.