RESULTS

BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer  (Scientific Reports, 2016)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Sueda et al. demonstrate that selective BRAF V600E inhibition activates AMP-activated protein kinase (AMPK), which induces autophagy as a mechanism of therapeutic resistance in human cancers. Present experiments suggest that the control of autophagy contributes to overcome the chemoresistance of BRAF V600E  cancer cells.