Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells （Cell Death Discovery, 2018, in press)

Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells （Cell Death Discovery, 2018, in press)
In collaboration with the Department of Radiation Oncology, Osaka University (Prof. Kazuhiko Ogawa), Tamari et al. revealed details of metabolic pathways that drive epigenetic control of cancer cell stemness and determine effective therapeutic targets in cancer stem cells (CSCs). The study indicated that intracellular polyamines inhibited the activity of histone lysine 4 demethylase enzymes, including lysine-specific demethylase-1 (LSD1), and demonstrated the significance in drug discovery.

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